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SELENOP selenoprotein P [ Homo sapiens (human) ]

Gene ID: 6414, updated on 11-Apr-2024

Summary

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Official Symbol
SELENOPprovided by HGNC
Official Full Name
selenoprotein Pprovided by HGNC
Primary source
HGNC:HGNC:10751
See related
Ensembl:ENSG00000250722 MIM:601484; AllianceGenome:HGNC:10751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SeP; SELP; SEPP; SEPP1
Summary
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]
Expression
Broad expression in liver (RPKM 1192.8), small intestine (RPKM 1057.6) and 22 other tissues See more
Orthologs
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Genomic context

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See SELENOP in Genome Data Viewer
Location:
5p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (42799880..42811892, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43052823..43064836, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (42799982..42811994, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2996 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42225166-42225693 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85146 Neighboring gene NANOG hESC enhancer GRCh37_chr5:42288621-42289193 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85179 Neighboring gene GHR upstream promoter region module A Neighboring gene zinc finger protein 35 pseudogene Neighboring gene SERPINE1 mRNA binding protein 1 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42508817-42509317 Neighboring gene growth hormone receptor Neighboring gene GHR downstream promoter region module B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42756975-42757476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42757477-42757976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42804335-42804835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:42803834-42804334 Neighboring gene coiled-coil domain containing 152 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:42812153-42812718 Neighboring gene uncharacterized LOC124900970 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:42847432-42847604 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:42886955-42888154 Neighboring gene peptidylprolyl isomerase A pseudogene 77

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults. Oo SM, et al. J ASEAN Fed Endocr Soc, 2023. PMID 37234930, Free PMC Article
  2. The role of selenoprotein P in the determining the sensitivity of cervical cancer patients to concurrent chemoradiotherapy: A metabonomics-based analysis. Qi L, et al. J Trace Elem Med Biol, 2022 Sep. PMID 35905604
  3. Elevated Selenoprotein P Levels in Thalassemia Major Patients. Talibova G, et al. Arch Med Res, 2022 Jul. PMID 35840466
  4. Autoimmunity to selenoprotein P predicts breast cancer recurrence. Demircan K, et al. Redox Biol, 2022 Jul. PMID 35636018, Free PMC Article
  5. Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis. Sun Q, et al. Int J Mol Sci, 2021 Dec 3. PMID 34884891, Free PMC Article

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant status in patients with suspected obstructive sleep apnea.
    Title: Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant status in patients with suspected obstructive sleep apnea.
  2. Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.
    Title: Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults.
  3. Association of Serum Selenium and Selenoprotein P with Oxidative Stress Biomarkers in Patients with Polycystic Ovary Syndrome.
    Title: Association of Serum Selenium and Selenoprotein P with Oxidative Stress Biomarkers in Patients with Polycystic Ovary Syndrome.
  4. Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage.
    Title: Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage.
  5. Selenoprotein P deficiency is associated with higher risk of incident heart failure.
    Title: Selenoprotein P deficiency is associated with higher risk of incident heart failure.
  6. SELENOP rs3877899 Variant Affects the Risk of Developing Advanced Stages of Retinopathy of Prematurity (ROP).
    Title: SELENOP rs3877899 Variant Affects the Risk of Developing Advanced Stages of Retinopathy of Prematurity (ROP).
  7. Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone.
    Title: Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone.
  8. SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
    Title: SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions.
  9. Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults.
    Title: Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults.
  10. The role of selenoprotein P in the determining the sensitivity of cervical cancer patients to concurrent chemoradiotherapy: A metabonomics-based analysis.
    Title: The role of selenoprotein P in the determining the sensitivity of cervical cancer patients to concurrent chemoradiotherapy: A metabonomics-based analysis.
Submit: New GeneRIF Correction See all GeneRIFs (103)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of selenoprotein P (SEPP1) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables selenium binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
  
involved_in response to selenium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in selenium compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sexual reproduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in platelet dense granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
selenoprotein P
Names
selenoprotein P, plasma, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085486.3 → NP_001078955.1  selenoprotein P isoform 1 precursor

    See identical proteins and their annotated locations for NP_001078955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Sepp1c) contains an additional 5' non-coding exon, and thus has a different and longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    HM005482
    Consensus CDS
    CCDS43311.1
    UniProtKB/Swiss-Prot
    P49908, Q6PD59, Q6PI43, Q6PI87, Q6PJF9
    UniProtKB/TrEMBL
    A0A182DWH7
    Related
    ENSP00000427671.1, ENST00000511224.5
    Conserved Domains (2) summary
    pfam04592
    Location:23 → 243
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:251 → 381
    SelP_C; Selenoprotein P, C terminal region

  2. NM_001093726.3 → NP_001087195.1  selenoprotein P isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as Sepp1b) contains an additional 5' coding exon compared to variant 1. It initiates translation from an in-frame, upstream start codon, which results in an isoform (2) with a longer and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL599162, BC040075, HM005482
    UniProtKB/Swiss-Prot
    P49908
    Conserved Domains (2) summary
    pfam04592
    Location:53 → 273
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:281 → 411
    SelP_C; Selenoprotein P, C terminal region

  3. NM_005410.4 → NP_005401.3  selenoprotein P isoform 1 precursor

    See identical proteins and their annotated locations for NP_005401.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC040075, DA288385, HM005482
    Consensus CDS
    CCDS43311.1
    UniProtKB/Swiss-Prot
    P49908, Q6PD59, Q6PI43, Q6PI87, Q6PJF9
    UniProtKB/TrEMBL
    A0A182DWH7
    Related
    ENSP00000420939.1, ENST00000514985.6
    Conserved Domains (2) summary
    pfam04592
    Location:23 → 243
    SelP_N; Selenoprotein P, N terminal region
    pfam04593
    Location:251 → 381
    SelP_C; Selenoprotein P, C terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    42799880..42811892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    43052823..43064836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49908.3 GenPept UniProtKB/Swiss-Prot:P49908

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