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Ctsm cathepsin M [ Mus musculus (house mouse) ]

Gene ID: 64139, updated on 2-Nov-2024

Summary

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Official Symbol
Ctsmprovided by MGI
Official Full Name
cathepsin Mprovided by MGI
Primary source
MGI:MGI:1927229
See related
Ensembl:ENSMUSG00000074871 AllianceGenome:MGI:1927229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Catm; 1600027J17Rik
Summary
Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in extraembryonic component; labyrinthine zone; and placenta. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta adult (RPKM 103.1) See more
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Genomic context

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See Ctsm in Genome Data Viewer
Location:
13 B2; 13 32.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61683553..61689697, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (61535739..61541883, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cathepsin M, pseudogene Neighboring gene STARR-seq mESC enhancer starr_34750 Neighboring gene predicted gene 7756 Neighboring gene cathepsin 3 Neighboring gene STARR-seq mESC enhancer starr_34751 Neighboring gene predicted gene, 21933

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Placental cathepsin M is alternatively spliced and exclusively expressed in the spongiotrophoblast layer. Bode S, et al. Biochim Biophys Acta, 2005 Dec 20. PMID 16297992
  2. Cathepsin gene expression in mouse placenta during the latter half of pregnancy. Ishida M, et al. J Reprod Dev, 2004 Oct. PMID 15514457
  3. Evolution of placentally expressed cathepsins. Sol-Church K, et al. Biochem Biophys Res Commun, 2002 Apr 26. PMID 12054558
  4. Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P. Sol-Church K, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760593
  5. Transient reduction of placental angiogenesis in PAI-1-deficient mice. Labied S, et al. Physiol Genomics, 2011 Feb 24. PMID 21119013

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Possible association of cathepsins with placental lactogen-II may play important roles in placental functions during the latter half of pregnancy in mice.
    Title: Cathepsin gene expression in mouse placenta during the latter half of pregnancy.
  2. shows evolution in placental expression by gene duplidatoin
    Title: Evolution of placentally expressed cathepsins.
  3. Placental cathepsin M is alternatively spliced and exclusively expressed in the spongiotrophoblast layer
    Title: Placental cathepsin M is alternatively spliced and exclusively expressed in the spongiotrophoblast layer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cathepsin M
Names
Cat M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360721.1 → NP_001347650.1  cathepsin M precursor

    Status: VALIDATED

    Source sequence(s)
    CT030254
    Consensus CDS
    CCDS36694.1
    UniProtKB/Swiss-Prot
    Q91Z75, Q91ZF3, Q9CQB9, Q9JL96
    UniProtKB/TrEMBL
    A0A0R4J182
    Related
    ENSMUSP00000097050.3, ENSMUST00000099451.4
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 331
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

  2. NM_022326.4 → NP_071721.2  cathepsin M precursor

    See identical proteins and their annotated locations for NP_071721.2

    Status: VALIDATED

    Source sequence(s)
    CT030254
    Consensus CDS
    CCDS36694.1
    UniProtKB/Swiss-Prot
    Q91Z75, Q91ZF3, Q9CQB9, Q9JL96
    UniProtKB/TrEMBL
    A0A0R4J182
    Related
    ENSMUSP00000153101.2, ENSMUST00000223778.2
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 331
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61683553..61689697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517311.4 → XP_006517374.1  cathepsin M isoform X2

    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 260
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

  2. XM_006517313.4 → XP_006517376.1  cathepsin M isoform X4

    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 260
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

  3. XM_006517312.4 → XP_006517375.1  cathepsin M isoform X3

    UniProtKB/Swiss-Prot
    Q91Z75, Q91ZF3, Q9CQB9, Q9JL96
    Conserved Domains (2) summary
    smart00848
    Location:1 → 32
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:60 → 276
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

  4. XM_011244547.3 → XP_011242849.1  cathepsin M isoform X1

    See identical proteins and their annotated locations for XP_011242849.1

    UniProtKB/Swiss-Prot
    Q91Z75, Q91ZF3, Q9CQB9, Q9JL96
    UniProtKB/TrEMBL
    A0A0R4J182
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    cd02248
    Location:115 → 331
    Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...

RNA

  1. XR_382443.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL96.1 GenPept UniProtKB/Swiss-Prot:Q9JL96

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