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PI3 peptidase inhibitor 3 [ Ovis aries (sheep) ]

Gene ID: 641305, updated on 5-Mar-2024

Summary

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Gene symbol
PI3
Gene description
peptidase inhibitor 3
See related
EnsemblRapid:ENSOARG00020039986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
TOM
Orthologs
human all
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Genomic context

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See PI3 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 13 NC_056066.1 (73444787..73446325)

Chromosome 13 - NC_056066.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 4 Neighboring gene potassium voltage-gated channel modifier subfamily S member 1 Neighboring gene WAP four-disulfide core domain 5 Neighboring gene WAP four-disulfide core domain 12 Neighboring gene antileukoproteinase-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056066.1 Chromosome 13 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trappin ovine molecule (TOM), the ovine ortholog of elafin, is an acute phase reactant in the lung. Brown TI, et al. Physiol Genomics, 2004 Sep 16. PMID 15292488
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. molecular cloning and characterization of the ovine orthologs of elafin, TOM-1 and TOM-2
    Title: Trappin ovine molecule (TOM), the ovine ortholog of elafin, is an acute phase reactant in the lung.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in copulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
elafin
Names
elastase-specific inhibitor
skin-derived antileukoproteinase
trappin ovine homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035224.1 → NP_001030301.1  elafin precursor

    See identical proteins and their annotated locations for NP_001030301.1

    Status: PROVISIONAL

    Source sequence(s)
    AY344541
    UniProtKB/TrEMBL
    A0A6P3CWM7, A0A836A805, Q6VB95
    Related
    ENSOARP00020058034.1, ENSOART00020073709.1
    Conserved Domains (1) summary
    smart00217
    Location:175 → 220
    WAP; Four-disulfide core domains

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056066.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    73444787..73446325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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