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Clstn2 calsyntenin 2 [ Mus musculus (house mouse) ]

Gene ID: 64085, updated on 2-Nov-2024

Summary

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Official Symbol
Clstn2provided by MGI
Official Full Name
calsyntenin 2provided by MGI
Primary source
MGI:MGI:1929897
See related
Ensembl:ENSMUSG00000032452 AllianceGenome:MGI:1929897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cs2; CSTN2; Cst-2; mKIAA4134; 2900042C18Rik
Summary
Predicted to enable calcium ion binding activity. Involved in associative learning and inhibitory synapse assembly. Acts upstream of or within positive regulation of synapse assembly and positive regulation of synaptic transmission. Located in cell surface; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; ear; forelimb bud; heart; and paraxial mesenchyme. Orthologous to human CLSTN2 (calsyntenin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 7.4), CNS E18 (RPKM 6.7) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Clstn2 in Genome Data Viewer
Location:
9 E3.3; 9 51.06 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (97326448..97915433, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (97444395..98033373, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 42 Neighboring gene STARR-seq mESC enhancer starr_24994 Neighboring gene predicted gene, 25607 Neighboring gene STARR-seq mESC enhancer starr_24995 Neighboring gene STARR-seq mESC enhancer starr_24997 Neighboring gene RIKEN cDNA 4921534H16 gene Neighboring gene STARR-seq mESC enhancer starr_25001 Neighboring gene STARR-positive B cell enhancer ABC_E6795 Neighboring gene STARR-positive B cell enhancer ABC_E10579 Neighboring gene predicted gene, 46126 Neighboring gene nicotinamide nucleotide adenylyltransferase 3 Neighboring gene predicted gene 28530

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vocal and physical phenotypes of calsyntenin2 knockout mouse pups model early-life symptoms of the autism spectrum disorder. Klenova AV, et al. Behav Brain Res, 2021 Aug 27. PMID 34182007
  2. Lack of synaptic protein, calsyntenin-2, impairs morphology of synaptic complexes in mice. Ranneva SV, et al. Synapse, 2020 Feb. PMID 31529526
  3. Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission. Lipina TV, et al. Neuropsychopharmacology, 2016 Feb. PMID 26171716, Free PMC Article
  4. Features of emotional and social behavioral phenotypes of calsyntenin2 knockout mice. Ranneva SV, et al. Behav Brain Res, 2017 Aug 14. PMID 28647593
  5. The calsyntenins--a family of postsynaptic membrane proteins with distinct neuronal expression patterns. Hintsch G, et al. Mol Cell Neurosci, 2002 Nov. PMID 12498782

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vocal and physical phenotypes of calsyntenin2 knockout mouse pups model early-life symptoms of the autism spectrum disorder.
    Title: Vocal and physical phenotypes of calsyntenin2 knockout mouse pups model early-life symptoms of the autism spectrum disorder.
  2. Lack of synaptic protein, calsyntenin-2, impairs morphology of synaptic complexes in mice.
    Title: Lack of synaptic protein, calsyntenin-2, impairs morphology of synaptic complexes in mice.
  3. Study explored the in vivo effects of calsyntenin-2 deficiency on emotional and social behavioral endophenotypes in a mouse, found a striking effect of sex on expression of social behavior and emotionality in Clstn2-knock-out mice, but hyperactivity coupled with pronounced repetitive behavior was observed in Clstn2-knock-out mice of both sexes.
    Title: Features of emotional and social behavioral phenotypes of calsyntenin2 knockout mice.
  4. Results confirm a function for calsyntenin-2 in cognitive performance and indicate an underlying mechanism that involves parvalbumin interneurons and aberrant inhibitory transmission
    Title: Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • KIAA4134

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in inhibitory synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calsyntenin-2
Names
alc-gamma
alcadein-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413406.1 → NP_001400335.1  calsyntenin-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC112521, AC116588, AC117219, AC147637
    Related
    ENSMUSP00000124081.2, ENSMUST00000162295.2

  2. NM_022319.3 → NP_071714.2  calsyntenin-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_071714.2

    Status: VALIDATED

    Source sequence(s)
    AC112521, AC116588, AC117219, AC147637
    Consensus CDS
    CCDS40733.1
    UniProtKB/Swiss-Prot
    Q5DTM0, Q6P565, Q8C858, Q9ER65
    Related
    ENSMUSP00000035027.7, ENSMUST00000035027.13
    Conserved Domains (1) summary
    cd11304
    Location:167 → 258
    Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    97326448..97915433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155170.1 → XP_036011063.1  calsyntenin-2 isoform X1

    Conserved Domains (1) summary
    cd11304
    Location:207 → 298
    Cadherin_repeat; Cadherin tandem repeat domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER65.2 GenPept UniProtKB/Swiss-Prot:Q9ER65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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