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PRSS22 serine protease 22 [ Homo sapiens (human) ]

Gene ID: 64063, updated on 5-Mar-2024

Summary

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Official Symbol
PRSS22provided by HGNC
Official Full Name
serine protease 22provided by HGNC
Primary source
HGNC:HGNC:14368
See related
Ensembl:ENSG00000005001 MIM:609343; AllianceGenome:HGNC:14368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BSSP-4; SP001LA; hBSSP-4
Summary
This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in the airways in a developmentally regulated manner. The gene is part of a cluster of serine protease genes on chromosome 16. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 17.2), stomach (RPKM 8.5) and 11 other tissues See more
Orthologs
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Genomic context

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See PRSS22 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2852730..2858170, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2873285..2879250, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2902731..2908171, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:2885634-2886833 Neighboring gene uncharacterized LOC124903628 Neighboring gene zymogen granule protein 16B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2892359-2893048 Neighboring gene serine protease 30, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2902227-2902726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2907556-2908156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908157-2908757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908758-2909357 Neighboring gene uncharacterized LOC101929566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2932133-2932633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7078 Neighboring gene FLYWCH family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling. Chen CY, et al. Mol Cancer, 2014 Jul 1. PMID 24980078, Free PMC Article
  2. A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells. Mitsui S, et al. FEBS J, 2005 Oct. PMID 16176265
  3. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. Yasuda S, et al. Blood, 2005 May 15. PMID 15701722, Free PMC Article
  4. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. Wong GW, et al. J Biol Chem, 2001 Dec 28. PMID 11602603
  5. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our findings collectively support a potential role of T3 in cancer cell progression through regulation of the BSSP4 protease via the ERK 1/2-C/EBPbeta-VEGF cascade
    Title: Thyroid hormone enhanced human hepatoma cell motility involves brain-specific serine protease 4 activation via ERK signaling.
  2. Tryptase epsilon also was able to induce pro-uPA-expressing smooth muscle cells to increase their migration
    Title: Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
  3. prosemin is a novel serine protease of the chromosome 16 cluster that is highly expressed in the pancreas.
    Title: A novel serine protease highly expressed in the pancreas is expressed in various kinds of cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC9599

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
brain-specific serine protease 4
Names
prosemin
protease, serine 22
protease, serine S1 family member 22
serine protease 26
tryptase epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046976.1 RefSeqGene

    Range
    5461..10901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022119.4 → NP_071402.1  brain-specific serine protease 4 precursor

    See identical proteins and their annotated locations for NP_071402.1

    Status: REVIEWED

    Source sequence(s)
    AF321182, AW083723, BQ893064
    Consensus CDS
    CCDS10481.1
    UniProtKB/Swiss-Prot
    O43342, Q6UXE0, Q9GZN4
    Related
    ENSP00000161006.3, ENST00000161006.8
    Conserved Domains (1) summary
    cd00190
    Location:50 → 288
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2852730..2858170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434451.1 → XP_047290407.1  brain-specific serine protease 4 isoform X1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_013171812.1 Reference GRCh38.p14 PATCHES

    Range
    32208..38173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331878.1 → XP_054187853.1  brain-specific serine protease 4 isoform X2

    UniProtKB/Swiss-Prot
    O43342, Q6UXE0, Q9GZN4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2873285..2879250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313605.1 → XP_054169580.1  brain-specific serine protease 4 isoform X2

    UniProtKB/Swiss-Prot
    O43342, Q6UXE0, Q9GZN4

  2. XM_054313604.1 → XP_054169579.1  brain-specific serine protease 4 isoform X3

  3. XM_054313606.1 → XP_054169581.1  brain-specific serine protease 4 isoform X1

  4. XM_054313607.1 → XP_054169582.1  brain-specific serine protease 4 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZN4.1 GenPept UniProtKB/Swiss-Prot:Q9GZN4

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