SELL selectin L [Homo sapiens (human)] - Gene

Summary

Official Symbol: SELLprovided by HGNC
Official Full Name: selectin Lprovided by HGNC
Primary source: HGNC:HGNC:10720
See related: Ensembl:ENSG00000188404 MIM:153240; AllianceGenome:HGNC:10720
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
Summary: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
Expression: Biased expression in lymph node (RPKM 120.3), spleen (RPKM 87.6) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q24.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (169690667..169711620, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (169046455..169067407, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (169659808..169680761, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intercellular adhesion molecule 1 and selectin l play crucial roles in ulcerative colitis.
Title: Intercellular adhesion molecule 1 and selectin l play crucial roles in ulcerative colitis.
CD62L expression marks a functionally distinct subset of memory B cells.
Title: CD62L expression marks a functionally distinct subset of memory B cells.
Sex-specific association of SELL gene polymorphisms with pattern hair loss in the Thai population: A candidate gene association study and in silico functional characterization.
Title: Sex-specific association of SELL gene polymorphisms with pattern hair loss in the Thai population: A candidate gene association study and in silico functional characterization.
The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma.
Title: The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma.
Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 Infection.
Title: Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 Infection.
CD62L expression level determines the cell fate of myeloid progenitors.
Title: CD62L expression level determines the cell fate of myeloid progenitors.
Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients.
Title: Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients.
Tumors exploit CXCR4(hi)CD62L(lo) aged neutrophils to facilitate metastatic spread.
Title: Tumors exploit CXCR4(hi)CD62L(lo) aged neutrophils to facilitate metastatic spread.
L-selectin regulates human neutrophil transendothelial migration.
Title: L-selectin regulates human neutrophil transendothelial migration.
An increase in CD62L(dim) neutrophils precedes the development of pulmonary embolisms in COVID-19 patients.
Title: An increase in CD62L(dim) neutrophils precedes the development of pulmonary embolisms in COVID-19 patients.

Submit: New GeneRIF Correction See all GeneRIFs (175)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	L-selectin downregulation induced by HIV-1 gp120 is completely reversed by AMD3100 (a CXCR4 antagonist), but not SDF-1 alpha	PubMed
	env	CD4 ligation by HIV-1 gp120 induces metalloproteinase-dependent L-selectin downregulation in primary resting CD4+ T cells	PubMed
Nef	nef	HIV-1 Nef mutants L37Q, 62EEEE/AAAA65, P72A/P75A, P78L, and F191A partially impair to downregulate CD62L in Jurkat cells	PubMed
	nef	Both HIV-1 Nef and Vpu downregulate the cell surface expression of selectin L (CD62L)	PubMed
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of selectin L (SELL) in primary human brain microvascular endothelial cells	PubMed
Vpu	vpu	HIV-1 Vpu inhibits the transport of newly synthesized CD62L molecules toward the cell surface of Jurkat cells	PubMed
	vpu	Both HIV-1 Nef and Vpu downregulate the cell surface expression of selectin L (CD62L)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11089 (e-PCR)
- UniSTS:37642

RH17452 (e-PCR)
- UniSTS:54539

G59836 (e-PCR)
- UniSTS:136985

AL034213 (e-PCR)
- UniSTS:94039

RH11088 (e-PCR)
- UniSTS:24468

WI-11175 (e-PCR)
- UniSTS:54973

D1S3431 (e-PCR)
- UniSTS:18627

RH104485 (e-PCR)
- UniSTS:98797

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	TAS Traceable Author Statement more info	PubMed
enables glycosphingolipid binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	TAS Traceable Author Statement more info	PubMed
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in leukocyte tethering or rolling	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: L-selectin

Names: CD62 antigen-like family member L; gp90-MEL; leukocyte surface antigen Leu-8; leukocyte-endothelial cell adhesion molecule 1; lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016132.1 RefSeqGene

Range

5083..26036

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000655.5 → NP_000646.3 L-selectin precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

AJ246000, BP393094, BQ004720, DA671852

Consensus CDS

CCDS53427.2

UniProtKB/Swiss-Prot

A0A024R8Z0, B2R6Q8, P14151, P15023, Q9UJ43

UniProtKB/TrEMBL

Q8WW79

Related

ENSP00000236147.5, ENST00000236147.6

Conserved Domains (3) summary

cd00033
Location:197 → 255

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:39 → 157

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

cd00054
Location:165 → 192

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RNA

NR_029467.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate 5' exons and has a distinct 5' end compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK298705, AL021940, BC020758, BP393094, CB164568, DC378123