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Pdcl phosducin like [ Rattus norvegicus (Norway rat) ]

Gene ID: 64013, updated on 17-Aug-2024

Summary

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Official Symbol
Pdclprovided by RGD
Official Full Name
phosducin likeprovided by RGD
Primary source
RGD:621135
See related
EnsemblRapid:ENSRNOG00000008484 AllianceGenome:RGD:621135
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Phlp; Pdcl1
Summary
Involved in negative regulation of protein refolding and protein folding. Predicted to be located in cytoplasm. Orthologous to human PDCL (phosducin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 207.2), Lung (RPKM 180.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pdcl in Genome Data Viewer
Location:
3q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41519953..41529545, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21110165..21119763, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21602349..21609821, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosome biogenesis regulator 1 homolog, pseudogene 1 Neighboring gene uncharacterized LOC120101901 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 2 Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene zinc finger and BTB domain containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. Thibault C, et al. Biochim Biophys Acta, 1999 Mar 19. PMID 10095058
  2. Interaction of phosducin-like protein with G protein betagamma subunits. Thibault C, et al. J Biol Chem, 1997 May 9. PMID 9139665
  3. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Miles MF, et al. Proc Natl Acad Sci U S A, 1993 Nov 15. PMID 8248177, Free PMC Article
  4. Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors. Lai CW, et al. J Neurosci, 2013 May 1. PMID 23637185, Free PMC Article
  5. Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. McLaughlin JN, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060742, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in heterotrimeric G-protein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heterotrimeric G-protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein refolding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosducin-like protein
Names
phosducin-like 1
NP_071583.1
XP_038961705.1
XP_063140566.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022247.2 → NP_071583.1  phosducin-like protein

    See identical proteins and their annotated locations for NP_071583.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q4V8L9, Q63737, Q63738
    UniProtKB/TrEMBL
    A0A8I6A6H0, A6JES8
    Conserved Domains (2) summary
    cd02987
    Location:51 → 272
    Phd_like_Phd; Phosducin (Phd)-like family, Phd subfamily; Phd is a cytosolic regulator of G protein functions. It specifically binds G protein betagamma (Gbg)-subunits with high affinity, resulting in the solubilization of Gbg from the plasma membrane. This impedes ...
    pfam02114
    Location:35 → 299
    Phosducin; Phosducin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    41519953..41529545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105777.2 → XP_038961705.1  phosducin-like protein isoform X2

    UniProtKB/TrEMBL
    A6JES9
    Conserved Domains (1) summary
    pfam02114
    Location:1 → 216
    Phosducin

  2. XM_063284496.1 → XP_063140566.1  phosducin-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q4V8L9, Q63737, Q63738
    UniProtKB/TrEMBL
    A0A8I6A6H0, A6JES8
    Related
    ENSRNOP00000012160.2, ENSRNOT00000012160.7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63737.1 GenPept UniProtKB/Swiss-Prot:Q63737

Gene LinkOut

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