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Arhgap17 Rho GTPase activating protein 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63994, updated on 10-Oct-2024

Summary

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Official Symbol
Arhgap17provided by RGD
Official Full Name
Rho GTPase activating protein 17provided by RGD
Primary source
RGD:628767
See related
EnsemblRapid:ENSRNOG00000013836 AllianceGenome:RGD:628767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rich1
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in cytoplasm. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 158.2), Spleen (RPKM 154.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap17 in Genome Data Viewer
Location:
1q36
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (187238675..187328093, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (177807579..177897027, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (193239036..193328425, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483807 Neighboring gene solute carrier family 5 member 11 Neighboring gene leucine carboxyl methyltransferase 1 Neighboring gene uncharacterized LOC134483809

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and functional characterization of nadrin variants, a novel family of GTPase activating protein for rho GTPases. Furuta B, et al. J Neurochem, 2002 Sep. PMID 12358749
  2. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. Harada A, et al. J Biol Chem, 2000 Nov 24. PMID 10967100
  3. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, et al. J Proteomics, 2020 Jun 30. PMID 32068187
  4. External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Galic M, et al. Nat Cell Biol, 2012 Aug. PMID 22750946, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93451

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium-ion regulated exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 17
Names
neuron-associated developmentally-regulated protein
neuron-specific GTPase-activating protein
rho-type GTPase-activating protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270692.1 → NP_001257621.1  rho GTPase-activating protein 17 isoform 1

    See identical proteins and their annotated locations for NP_001257621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB042827, BC085736
    UniProtKB/Swiss-Prot
    Q8R506, Q99N37, Q99N38, Q9EQV7
    UniProtKB/TrEMBL
    F1M6X7
    Related
    ENSRNOP00000038504.7, ENSRNOT00000031770.9
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  2. NM_001270693.1 → NP_001257622.1  rho GTPase-activating protein 17 isoform 3

    See identical proteins and their annotated locations for NP_001257622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon with an in-frame stop codon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB042827, BC085736, JAXUCZ010000001
    UniProtKB/TrEMBL
    D4AAV4
    Related
    ENSRNOP00000019309.8, ENSRNOT00000019309.10
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  3. NM_001270694.1 → NP_001257623.1  rho GTPase-activating protein 17 isoform 4

    See identical proteins and their annotated locations for NP_001257623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and contains an alternate 3' exon with an in-frame stop codon compared to variant 1. The resulting isoform (4) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB042827, BC085736, JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ALM5
    Related
    ENSRNOP00000019305.9, ENSRNOT00000019304.9
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

  4. NM_022244.2 → NP_071580.1  rho GTPase-activating protein 17 isoform 2

    See identical proteins and their annotated locations for NP_071580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB042827, BC085736
    UniProtKB/TrEMBL
    A6I8Z6
    Related
    ENSRNOP00000076440.2, ENSRNOT00000097528.2
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    187238675..187328093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089209.2 → XP_038945137.1  rho GTPase-activating protein 17 isoform X1

    UniProtKB/TrEMBL
    F1M6X7
    Related
    ENSRNOP00000080152.2, ENSRNOT00000105291.2
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

  2. XM_039089216.2 → XP_038945144.1  rho GTPase-activating protein 17 isoform X4

    UniProtKB/TrEMBL
    A6I8Z6
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

  3. XM_039089217.2 → XP_038945145.1  rho GTPase-activating protein 17 isoform X6

    Conserved Domains (1) summary
    cd04386
    Location:1 → 173
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

  4. XM_006230194.5 → XP_006230256.2  rho GTPase-activating protein 17 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y535, A0A8I5ZP42
    Conserved Domains (2) summary
    cd07618
    Location:13 → 257
    BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
    cd04386
    Location:246 → 446
    RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...

  5. XM_063272630.1 → XP_063128700.1  rho GTPase-activating protein 17 isoform X2

  6. XM_063272639.1 → XP_063128709.1  rho GTPase-activating protein 17 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N37.1 GenPept UniProtKB/Swiss-Prot:Q99N37

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