Slc29a1 solute carrier family 29 (nucleoside transporters), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc29a1provided by MGI
Official Full Name: solute carrier family 29 (nucleoside transporters), member 1provided by MGI
Primary source: MGI:MGI:1927073
See related: Ensembl:ENSMUSG00000023942 AllianceGenome:MGI:1927073
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ENT1; mENT1; 1200014D21Rik
Summary: Enables neurotransmitter transmembrane transporter activity; purine nucleoside transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in neurotransmitter uptake and nucleoside transport. Acts upstream of or within nucleoside transport. Is active in plasma membrane. Is expressed in several structures, including central nervous system; hemolymphoid system; hindlimb phalanx; liver; and skeletal musculature. Used to study alcohol dependence and diffuse idiopathic skeletal hyperostosis. Orthologous to human SLC29A1 (solute carrier family 29 member 1 (Augustine blood group)). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in liver adult (RPKM 135.7), adrenal adult (RPKM 95.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3- C; 17 22.59 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (45896126..45910544, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (45585200..45599618, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.
Title: Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.
Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
Title: Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury.
Title: Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury.
The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis.
Title: The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis.
Type 1 equilibrative nucleoside transporter (ENT1) regulates sex-specific ethanol drinking during disruption of circadian rhythms.
Title: Type 1 equilibrative nucleoside transporter (ENT1) regulates sex-specific ethanol drinking during disruption of circadian rhythms.
Maternal erythrocyte ENT1-mediated AMPK activation counteracts placental hypoxia and supports fetal growth.
Title: Maternal erythrocyte ENT1-mediated AMPK activation counteracts placental hypoxia and supports fetal growth.
GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism.
Title: GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism.
ENT1/2 chemical inhibition and ENT1 knockout prevented P. aeruginosa-induced lung NLRP3 inflammasome activation.
Title: Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation.
The current study demonstrates that loss of ENT1-mediated adenosine transport leads to increased cell proliferation in the annulus fibrosus of the intervertebral disc
Title: Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc.
The results of this study suggested that binge alcohol consumption-induced down-regulation of ENT1 expression may disrupt sleep homeostasis and cause sleep disturbances
Title: A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis, and down-regulates equilibrative nucleoside transporter 1.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc29a1 (e-PCR), detects polymorphism
- UniSTS:547328

RH124615 (e-PCR)
- UniSTS:161437

AI046673 (e-PCR)
- UniSTS:209311

RH125700 (e-PCR)
- UniSTS:162470

Slc29a1 (e-PCR), detects polymorphism
- UniSTS:186543

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables adenine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cytidine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cytidine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables guanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleoside transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables purine nucleoside transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables purine nucleoside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables purine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uracil transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uracil transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables uridine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenine transport	ISO Inferred from Sequence Orthology more info
involved_in adenine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenosine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenosine transport	ISO Inferred from Sequence Orthology more info
involved_in adenosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cytidine transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in guanine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in guanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine transport	IEA Inferred from Electronic Annotation more info
involved_in hypoxanthine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inosine transport	ISO Inferred from Sequence Orthology more info
involved_in inosine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter uptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase transport	ISO Inferred from Sequence Orthology more info
involved_in nucleobase transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleoside transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleobase transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thymine transport	IEA Inferred from Electronic Annotation more info
involved_in thymine transport	ISO Inferred from Sequence Orthology more info
involved_in uracil transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uracil transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in uridine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: equilibrative nucleoside transporter 1

Names: NBMPR-sensitive equilibrative nucleoside transporter; equilibrative NBMPR-sensitive nucleoside transporter; equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; nucleoside transporter, es-type; solute carrier family 29 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199113.2 → NP_001186042.1 equilibrative nucleoside transporter 1 isoform 1

See identical proteins and their annotated locations for NP_001186042.1

Status: VALIDATED

Source sequence(s)

AC163677

Consensus CDS

CCDS57096.1

UniProtKB/Swiss-Prot

Q99K84, Q9DBT8, Q9JHF0, Q9JIM1

UniProtKB/TrEMBL

Q3UJY1

Related

ENSMUSP00000131976.2, ENSMUST00000167692.8

Conserved Domains (1) summary

TIGR00939
Location:18 → 460

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001199114.2 → NP_001186043.1 equilibrative nucleoside transporter 1 isoform 1

See identical proteins and their annotated locations for NP_001186043.1

Status: VALIDATED

Source sequence(s)

AC163677

Consensus CDS

CCDS57096.1

UniProtKB/Swiss-Prot

Q99K84, Q9DBT8, Q9JHF0, Q9JIM1

UniProtKB/TrEMBL

Q3UJY1

Related

ENSMUSP00000094923.4, ENSMUST00000097317.10

Conserved Domains (1) summary

TIGR00939
Location:18 → 460

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001199115.2 → NP_001186044.1 equilibrative nucleoside transporter 1 isoform 2

See identical proteins and their annotated locations for NP_001186044.1

Status: VALIDATED

Source sequence(s)

AC163677

Consensus CDS

CCDS28813.1

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Related

ENSMUSP00000126703.2, ENSMUST00000171847.8

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001199116.2 → NP_001186045.1 equilibrative nucleoside transporter 1 isoform 2

See identical proteins and their annotated locations for NP_001186045.1

Status: VALIDATED

Source sequence(s)

AC163677

Consensus CDS

CCDS28813.1

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Related

ENSMUSP00000063757.7, ENSMUST00000064889.13

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001357771.2 → NP_001344700.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC163677

Consensus CDS

CCDS28813.1

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376987.1 → NP_001363916.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/Swiss-Prot

Q99K84, Q9DBT8, Q9JHF0, Q9JIM1

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 460

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376988.1 → NP_001363917.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/Swiss-Prot

Q99K84, Q9DBT8, Q9JHF0, Q9JIM1

UniProtKB/TrEMBL

Q3UJY1

Related

ENSMUSP00000063096.7, ENSMUST00000051574.13

Conserved Domains (1) summary

TIGR00939
Location:18 → 460

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376989.1 → NP_001363918.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/Swiss-Prot

Q99K84, Q9DBT8, Q9JHF0, Q9JIM1

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 460

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376990.1 → NP_001363919.1 equilibrative nucleoside transporter 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/Swiss-Prot

Q99K84, Q9DBT8, Q9JHF0, Q9JIM1

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 460

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376991.1 → NP_001363920.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376992.1 → NP_001363921.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376993.1 → NP_001363922.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376994.1 → NP_001363923.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376995.1 → NP_001363924.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376996.1 → NP_001363925.1 equilibrative nucleoside transporter 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376997.1 → NP_001363926.1 equilibrative nucleoside transporter 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:1 → 426

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_001376998.1 → NP_001363927.1 equilibrative nucleoside transporter 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC163677

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:1 → 426

2a57; Equilibrative Nucleoside Transporter (ENT)
NM_022880.4 → NP_075018.1 equilibrative nucleoside transporter 1 isoform 2

See identical proteins and their annotated locations for NP_075018.1

Status: VALIDATED

Source sequence(s)

AC163677

Consensus CDS

CCDS28813.1

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Related

ENSMUSP00000129242.2, ENSMUST00000163492.8

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

45896126..45910544 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160736.1 → XP_036016629.1 equilibrative nucleoside transporter 1 isoform X4

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:1 → 426

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_036160735.1 → XP_036016628.1 equilibrative nucleoside transporter 1 isoform X3

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:1 → 428

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_006524773.3 → XP_006524836.1 equilibrative nucleoside transporter 1 isoform X3

See identical proteins and their annotated locations for XP_006524836.1

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:1 → 428

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_036160734.1 → XP_036016627.1 equilibrative nucleoside transporter 1 isoform X1

UniProtKB/Swiss-Prot

Q99K84, Q9DBT8, Q9JHF0, Q9JIM1

UniProtKB/TrEMBL

Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 460

2a57; Equilibrative Nucleoside Transporter (ENT)
XM_030249966.2 → XP_030105826.1 equilibrative nucleoside transporter 1 isoform X2

UniProtKB/TrEMBL

Q3TCZ2, Q3UJY1

Conserved Domains (1) summary

TIGR00939
Location:18 → 458

2a57; Equilibrative Nucleoside Transporter (ENT)