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Ugt2a1 UDP glucuronosyltransferase family 2 member A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63867, updated on 2-Nov-2024

Summary

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Official Symbol
Ugt2a1provided by RGD
Official Full Name
UDP glucuronosyltransferase family 2 member A1provided by RGD
Primary source
RGD:69432
See related
EnsemblRapid:ENSRNOG00000064759 AllianceGenome:RGD:69432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ugt2a1p
Summary
Predicted to enable glucuronosyltransferase activity. Predicted to be involved in bile acid metabolic process; cellular glucuronidation; and sensory perception of chemical stimulus. Predicted to be located in membrane. Orthologous to human UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 2.0) See more
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Genomic context

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See Ugt2a1 in Genome Data Viewer
Location:
14p21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (20797262..20825111)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (20521018..20545934)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (22192970..22217094)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1D, member 1 Neighboring gene sulfotransferase family 1B member 1 Neighboring gene UDP glucuronosyltransferase family 2 member A3 Neighboring gene kelch repeat and BTB domain-containing protein 8-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response. Neiers F, et al. PLoS One, 2021. PMID 33765098, Free PMC Article
  2. Odorant signal termination by olfactory UDP glucuronosyl transferase. Lazard D, et al. Nature, 1991 Feb 28. PMID 1900353
  3. Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3. Sneitz N, et al. Pharmacogenet Genomics, 2009 Dec. PMID 19858781, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.
    Title: The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular glucuronidation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to toxic substance TAS
Traceable Author Statement
more info
 PubMed 
involved_in sensory perception of chemical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of chemical stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase 2A1
Names
UDP glucuronosyltransferase 2 family, polypeptide A1
UDP glycosyltransferase 2 family, polypeptide A1
UDPGT 2A1
UGT-OLF
NP_071564.2
XP_038948318.1
XP_063129641.1
XP_063129642.1
XP_063129643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022228.2 → NP_071564.2  UDP-glucuronosyltransferase 2A1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P36510
    UniProtKB/TrEMBL
    A6KU27
    Related
    ENSRNOP00000002704.7, ENSRNOT00000002704.8
    Conserved Domains (1) summary
    pfam00201
    Location:21 → 523
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    20797262..20825111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273572.1 → XP_063129642.1  UDP-glucuronosyltransferase 2A1 isoform X2

    UniProtKB/TrEMBL
    A6KU27

  2. XM_063273573.1 → XP_063129643.1  UDP-glucuronosyltransferase 2A1 isoform X3

  3. XM_039092390.2 → XP_038948318.1  UDP-glucuronosyltransferase 2A1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMC7
    Related
    ENSRNOP00000097034.1, ENSRNOT00000100605.2
    Conserved Domains (1) summary
    pfam00201
    Location:22 → 524
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

  4. XM_063273571.1 → XP_063129641.1  UDP-glucuronosyltransferase 2A1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMC7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36510.1 GenPept UniProtKB/Swiss-Prot:P36510

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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