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Fgf14 fibroblast growth factor 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63851, updated on 2-Nov-2024

Summary

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Official Symbol
Fgf14provided by RGD
Official Full Name
fibroblast growth factor 14provided by RGD
Primary source
RGD:620165
See related
EnsemblRapid:ENSRNOG00000009288 AllianceGenome:RGD:620165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fhf4; FGF-14
Summary
Enables growth factor activity. Acts upstream of or within several processes, including positive regulation of high voltage-gated calcium channel activity; regulation of postsynaptic membrane potential; and regulation of synaptic vesicle recycling. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human FGF14 (fibroblast growth factor 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 168.3) See more
Orthologs
human mouse all
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Genomic context

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See Fgf14 in Genome Data Viewer
Location:
15q25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (107442800..108086486, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (101045033..101679888, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (110382274..111077027, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6atac minor spliceosomal RNA Neighboring gene integrin subunit beta like 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Ssu72 RNA polymerase II CTD phosphatase, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 91 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC120097183 Neighboring gene olfactory receptor pseudogene 1647 Neighboring gene pyruvate kinase M1/2, pseudogene 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural analysis of a mature hst-1 protein with transforming growth factor activity. Miyagawa K, et al. Biochem Biophys Res Commun, 1991 Jan 15. PMID 1824921
  2. FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. Yan H, et al. Cell Rep, 2013 Jul 11. PMID 23831029, Free PMC Article
  3. Structure and expression of a novel isoform of mouse FGF homologous factor (FHF)-4. Yamamoto S, et al. Biochim Biophys Acta, 1998 May 29. PMID 9602045
  4. Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells. Martinez-Espinosa PL, et al. J Gen Physiol, 2021 Apr 5. PMID 33651884, Free PMC Article
  5. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Goldfarb M, et al. Neuron, 2007 Aug 2. PMID 17678857, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
    Title: Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
  2. identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
    Title: Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
  3. FGF14 regulates presynaptic Ca2+ channels in granule cell and EPSCs in Purkinje cells.
    Title: FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.
  4. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.
    Title: The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromuscular process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of high voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic vesicle recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor 14
Names
FGF homologus factor 4b
fibroblast growth factor homologous factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411965.1 → NP_001398894.1  fibroblast growth factor 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I6A9Y8, A6HUN2, Q794I6
    Related
    ENSRNOP00000088042.1, ENSRNOT00000102677.2

  2. NM_022223.3 → NP_071559.2  fibroblast growth factor 14 isoform 1

    See identical proteins and their annotated locations for NP_071559.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q8R5L7
    UniProtKB/TrEMBL
    A6HUN3
    Related
    ENSRNOP00000042838.5, ENSRNOT00000041551.7
    Conserved Domains (1) summary
    pfam00167
    Location:72 → 197
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    107442800..108086486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093636.2 → XP_038949564.1  fibroblast growth factor 14 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9Y8, A6HUN2, Q794I6
    Conserved Domains (1) summary
    pfam00167
    Location:77 → 202
    FGF; Fibroblast growth factor

  2. XM_063274614.1 → XP_063130684.1  fibroblast growth factor 14 isoform X2

  3. XM_039093639.2 → XP_038949567.1  fibroblast growth factor 14 isoform X2

    UniProtKB/TrEMBL
    Q8R4X0
    Conserved Domains (1) summary
    pfam00167
    Location:1 → 113
    FGF; Fibroblast growth factor

  4. XM_063274613.1 → XP_063130683.1  fibroblast growth factor 14 isoform X2

  5. XM_063274611.1 → XP_063130681.1  fibroblast growth factor 14 isoform X2

  6. XM_063274612.1 → XP_063130682.1  fibroblast growth factor 14 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5L7.1 GenPept UniProtKB/Swiss-Prot:Q8R5L7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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