Prlh prolactin releasing hormone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prlhprovided by RGD
Official Full Name: prolactin releasing hormoneprovided by RGD
Primary source: RGD:628634
See related: EnsemblRapid:ENSRNOG00000019871 AllianceGenome:RGD:628634
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Prh; prrp
Summary: Enables neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Involved in G protein-coupled receptor signaling pathway and feeding behavior. Acts upstream of or within reduction of food intake in response to dietary excess. Located in cytoplasm. Used to study obesity. Orthologous to human PRLH (prolactin releasing hormone). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 5.6) and Lung (RPKM 0.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (98991628..98996515)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (91543128..91549022)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (98111391..98114831)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brainstem prolactin-releasing peptide contributes to cancer anorexia-cachexia syndrome in rats.
Title: Brainstem prolactin-releasing peptide contributes to cancer anorexia-cachexia syndrome in rats.
Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia.
Title: Colocalized neurotransmitters in the hindbrain cooperate in adaptation to chronic hypernatremia.
Possible involvement of Stat3 and Prlh1/Chgb up-regulation in the transition from short to repeated stress activation.
Title: A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress.
The medial amygdala-medullary PrRP-synthesizing neuron pathway plays an important role in neuroendocrine responses to contextual conditioned fear
Title: The medial amygdala-medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents.
PrRP increases the amplitude of the GABAA receptor-mediated inhibitory postsynaptic current in both ventrobasal nucleus and reticular thalamic nucleus neurons.
Title: Prolactin-releasing peptide enhances synaptic transmission in rat thalamus.
PrRP may play a previously unknown role in the area postrema of postnatal rats
Title: Appearance of prolactin-releasing peptide-producing cells in the area postrema of postnatal rats.
PrRP inhibited prolactin release at 0.1 and 1 nm in a pertussis toxin-sensitive manner
Title: Stimulation and inhibition of prolactin release by prolactin-releasing Peptide in rat anterior pituitary cell aggregates.
The data clearly showed that PrRP cells in DES-administered rats significantly suppressed c-Fos accumulation induced by stress.
Title: Estrogen suppresses the stress response of prolactin-releasing peptide-producing cells.
PrRP exerts its effects on energy homeostasis in the short-medium term by reducing food intake and increasing energy expenditure.
Title: Repeated administration of the anorectic factor prolactin-releasing peptide leads to tolerance to its effects on energy homeostasis.
The relatively low level of Prh in the hypothalamus and the lack of significant changes in expression during the estrous cycle and lactation provides further evidence that Prh is unlikely to be involved in the regulation of prolactin secretion.
Title: Quantification of prolactin-releasing peptide (PrRP) mRNA expression in specific brain regions of the rat during the oestrous cycle and in lactation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables prolactin receptor binding	TAS Traceable Author Statement more info	PubMed
enables prolactin-releasing peptide receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin-releasing peptide receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within autonomic nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eating behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy reserve metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reduction of food intake in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to glucose	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to peptide hormone	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prolactin-releasing peptide

Names: preproprolactin-releasing peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.