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Tmeff1 transmembrane protein with EGF-like and two follistatin-like domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 63845, updated on 10-Oct-2024

Summary

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Official Symbol
Tmeff1provided by RGD
Official Full Name
transmembrane protein with EGF-like and two follistatin-like domains 1provided by RGD
Primary source
RGD:62005
See related
EnsemblRapid:ENSRNOG00000008034 AllianceGenome:RGD:62005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Predicted to be located in plasma membrane. Predicted to be active in basement membrane. Orthologous to several human genes including MSANTD3-TMEFF1 (MSANTD3-TMEFF1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 214.2), Lung (RPKM 94.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmeff1 in Genome Data Viewer
Location:
5q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (67706269..67792022)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (62910740..62996494)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64326733..64412531)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene inversin Neighboring gene testis expressed 10 Neighboring gene uncharacterized LOC108350968 Neighboring gene Myb/SANT DNA binding domain containing 3 Neighboring gene caveolae associated protein 4 Neighboring gene uncharacterized LOC134487066

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TMEFF1 and brain tumors. Gery S, et al. Oncogene, 2003 May 8. PMID 12743596
  2. Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development. Eib DW, et al. Mech Dev, 2000 Oct. PMID 11025219
  3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tomoregulin-1
Names
TR-1
transmembrane protein with EGF-like and one follistatin-like domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429960.1 → NP_001416889.1  tomoregulin-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6A3D5

  2. NM_023020.3 → NP_075409.1  tomoregulin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075409.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q9QYV1
    UniProtKB/TrEMBL
    A0A8I5Y818
    Related
    ENSRNOP00000063443.2, ENSRNOT00000065775.4
    Conserved Domains (2) summary
    PHA02887
    Location:268 → 304
    PHA02887; EGF-like protein; Provisional
    smart00280
    Location:92 → 136
    KAZAL; Kazal type serine protease inhibitors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    67706269..67792022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110701.2 → XP_038966629.1  tomoregulin-1 isoform X1

    Related
    ENSRNOP00000103683.1, ENSRNOT00000136411.1
    Conserved Domains (3) summary
    PHA02887
    Location:268 → 304
    PHA02887; EGF-like protein; Provisional
    PHA03099
    Location:268 → 355
    PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
    smart00280
    Location:92 → 136
    KAZAL; Kazal type serine protease inhibitors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYV1.1 GenPept UniProtKB/Swiss-Prot:Q9QYV1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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