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CCL11 C-C motif chemokine ligand 11 [ Homo sapiens (human) ]

Gene ID: 6356, updated on 18-Sep-2024

Summary

Official Symbol
CCL11provided by HGNC
Official Full Name
C-C motif chemokine ligand 11provided by HGNC
Primary source
HGNC:HGNC:10610
See related
Ensembl:ENSG00000172156 MIM:601156; AllianceGenome:HGNC:10610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCYA11
Summary
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
Expression
Biased expression in appendix (RPKM 20.0), small intestine (RPKM 18.8) and 9 other tissues See more
Orthologs
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Genomic context

See CCL11 in Genome Data Viewer
Location:
17q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (34285742..34288334)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (35232017..35234610)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (32612761..32615353)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:32582001-32582975 Neighboring gene C-C motif chemokine ligand 2 Neighboring gene C-C motif chemokine ligand 7 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:32624651-32625240 Neighboring gene C-C motif chemokine ligand 8 Neighboring gene C-C motif chemokine ligand 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Inherited susceptibility to asthma
MedGen: C1869116 OMIM: 600807 GeneReviews: Not available
Compare labs
Susceptibility to HIV infection
MedGen: C1836230 OMIM: 609423 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 utilization of CCR3 as a coreceptor facilitates infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibits infection by these isolates PubMed
Vpu vpu The gene expression of eotaxin increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates eotaxin protein expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC22554

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables CCR3 chemokine receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament organization IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in chronic inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eosinophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular calcium ion homeostasis TAS
Traceable Author Statement
more info
 
involved_in killing of cells of another organism IDA
Inferred from Direct Assay
more info
PubMed 
involved_in learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary duct terminal end bud growth IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interleukin-13 IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-4 IEA
Inferred from Electronic Annotation
more info
 
involved_in response to radiation TAS
Traceable Author Statement
more info
PubMed 
involved_in response to virus TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
eotaxin
Names
chemokine (C-C motif) ligand 11
eosinophil chemotactic protein
eotaxin-1
small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012212.1 RefSeqGene

    Range
    5075..7667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002986.3NP_002977.1  eotaxin precursor

    See identical proteins and their annotated locations for NP_002977.1

    Status: REVIEWED

    Source sequence(s)
    AC005549, AI446061, BF197516, U46573, Z75668
    Consensus CDS
    CCDS11279.1
    UniProtKB/Swiss-Prot
    P50877, P51671, Q92490, Q92491
    UniProtKB/TrEMBL
    Q6I9T4
    Related
    ENSP00000302234.3, ENST00000305869.4
    Conserved Domains (1) summary
    pfam00048
    Location:3087
    IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    34285742..34288334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    35232017..35234610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)