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SCTR secretin receptor [ Homo sapiens (human) ]

Gene ID: 6344, updated on 11-Apr-2024

Summary

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Official Symbol
SCTRprovided by HGNC
Official Full Name
secretin receptorprovided by HGNC
Primary source
HGNC:HGNC:10608
See related
Ensembl:ENSG00000080293 MIM:182098; AllianceGenome:HGNC:10608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SR
Summary
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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See SCTR in Genome Data Viewer
Location:
2q14.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119439843..119524483, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119873301..119957984, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120197419..120282059, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 76 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16451 Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120189865-120190371 Neighboring gene transmembrane protein 37 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120231245-120231796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120232347-120232897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene SCTR antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11908 Neighboring gene cilia and flagella associated protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11909 Neighboring gene MPRA-validated peak3833 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11911 Neighboring gene transmembrane protein 177 Neighboring gene ribosomal protein L17 pseudogene 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein. Fukuhara S, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 33008599
  2. SCTR hypermethylation is a diagnostic biomarker in colorectal cancer. Li D, et al. Cancer Sci, 2020 Dec. PMID 32970347, Free PMC Article
  3. Structure and dynamics of the active Gs-coupled human secretin receptor. Dong M, et al. Nat Commun, 2020 Aug 18. PMID 32811827, Free PMC Article
  4. Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor. Dong M, et al. J Biol Chem, 2016 Mar 4. PMID 26740626, Free PMC Article
  5. SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells. Kang S, et al. Int J Oncol, 2015 Nov. PMID 26397240

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
    Title: Expression of Secretin and its Receptor Along the Intestinal Tract in Type 2 Diabetes Patients and Healthy Controls.
  2. Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
    Title: Inhibition of Secretin/Secretin Receptor Axis Ameliorates NAFLD Phenotypes.
  3. Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
    Title: Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.
  4. SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
    Title: SCTR hypermethylation is a diagnostic biomarker in colorectal cancer.
  5. Structure and dynamics of the active Gs-coupled human secretin receptor.
    Title: Structure and dynamics of the active Gs-coupled human secretin receptor.
  6. High secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
    Title: Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.
  7. elevated in primary sclerosing cholangitis liver samples compared to healthy controls
    Title: The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-β1 biliary secretion in mice.
  8. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
    Title: Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors.
  9. Cysteine trapping identified charge-charge interactions between secretin and secretin receptor residues in TM5, TM6, ECL2, and ECL3 domains.
    Title: Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.
  10. Our findings indicate that SCTR suppresses the proliferation of normal breast cells, while the gene stimulates the proliferation and migration of cancer cells being downregulated by promoter methylation.
    Title: SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables secretin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables secretin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in diet induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular water homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
secretin receptor
Names
pancreatic secretin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029904.1 RefSeqGene

    Range
    4970..89610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002980.3 → NP_002971.2  secretin receptor precursor

    See identical proteins and their annotated locations for NP_002971.2

    Status: REVIEWED

    Source sequence(s)
    AC013275
    Consensus CDS
    CCDS2127.1
    UniProtKB/Swiss-Prot
    P47872, Q12961, Q13213, Q53T00
    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
    Related
    ENSP00000019103.6, ENST00000019103.8
    Conserved Domains (2) summary
    pfam00002
    Location:139 → 384
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:64 → 126
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    119439843..119524483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511621.3 → XP_011509923.1  secretin receptor isoform X3

    UniProtKB/TrEMBL
    B2RBF3, Q8IV17
    Conserved Domains (2) summary
    pfam00002
    Location:139 → 389
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:64 → 126
    HRM; Hormone receptor domain

  2. XM_047445401.1 → XP_047301357.1  secretin receptor isoform X5

  3. XM_047445400.1 → XP_047301356.1  secretin receptor isoform X2

  4. XM_047445399.1 → XP_047301355.1  secretin receptor isoform X1

  5. XM_017004670.2 → XP_016860159.2  secretin receptor isoform X4

  6. XM_047445403.1 → XP_047301359.1  secretin receptor isoform X7

  7. XM_047445402.1 → XP_047301358.1  secretin receptor isoform X6

  8. XM_047445404.1 → XP_047301360.1  secretin receptor isoform X8

RNA

  1. XR_922984.3 RNA Sequence

  2. XR_001738889.2 RNA Sequence

  3. XR_007079571.1 RNA Sequence

  4. XR_001738888.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    119873301..119957984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343329.1 → XP_054199304.1  secretin receptor isoform X3

  2. XM_054343331.1 → XP_054199306.1  secretin receptor isoform X5

  3. XM_054343328.1 → XP_054199303.1  secretin receptor isoform X2

  4. XM_054343327.1 → XP_054199302.1  secretin receptor isoform X1

  5. XM_054343330.1 → XP_054199305.1  secretin receptor isoform X4

  6. XM_054343333.1 → XP_054199308.1  secretin receptor isoform X7

  7. XM_054343332.1 → XP_054199307.1  secretin receptor isoform X6

  8. XM_054343334.1 → XP_054199309.1  secretin receptor isoform X8

RNA

  1. XR_008486482.1 RNA Sequence

  2. XR_008486484.1 RNA Sequence

  3. XR_008486481.1 RNA Sequence

  4. XR_008486483.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47872.2 GenPept UniProtKB/Swiss-Prot:P47872

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