Fscb fibrous sheath CABYR binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fscbprovided by MGI
Official Full Name: fibrous sheath CABYR binding proteinprovided by MGI
Primary source: MGI:MGI:3646964
See related: Ensembl:ENSMUSG00000043060 AllianceGenome:MGI:3646964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG623046
Summary: Enables calcium ion binding activity. Involved in negative regulation of protein sumoylation. Located in sperm fibrous sheath and sperm principal piece. Is expressed in male reproductive gland or organ. Orthologous to human FSCB (fibrous sheath CABYR binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 12 C1; 12 26.96 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (64518107..64521672, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (64471333..64474898, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FSCB contributes to spermatozoa capacitation.
Title: FSCB phosphorylation in mouse spermatozoa capacitation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
is_active_in sperm fibrous sheath	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm fibrous sheath	IDA Inferred from Direct Assay more info	PubMed
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fibrous sheath CABYR-binding protein

Names: PKA phosphorylated calcium and CABYR-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163271.1 → NP_001156743.1 fibrous sheath CABYR-binding protein

Status: VALIDATED

Source sequence(s)

CR974484

Consensus CDS

CCDS49073.1

UniProtKB/Swiss-Prot

A1EGX6

UniProtKB/TrEMBL

E9QJV1

Related

ENSMUSP00000051554.7, ENSMUST00000059833.8

Conserved Domains (2) summary

PHA03247
Location:434 → 887

PHA03247; large tegument protein UL36; Provisional

PRK10811
Location:828 → 997

rne; ribonuclease E; Reviewed