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Tmem170b transmembrane protein 170B [ Mus musculus (house mouse) ]

Gene ID: 621976, updated on 30-Apr-2024

Summary

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Official Symbol
Tmem170bprovided by MGI
Official Full Name
transmembrane protein 170Bprovided by MGI
Primary source
MGI:MGI:3647046
See related
Ensembl:ENSMUSG00000087370 AllianceGenome:MGI:3647046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG621976
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM170B (transmembrane protein 170B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 6.2), CNS E18 (RPKM 5.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem170b in Genome Data Viewer
Location:
13 A4; 13 20.55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41759358..41794830)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41605882..41641354)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene neural precursor cell expressed, developmentally down-regulated gene 9 Neighboring gene predicted gene, 32448 Neighboring gene STARR-seq mESC enhancer starr_34303 Neighboring gene STARR-positive B cell enhancer ABC_E2404 Neighboring gene predicted gene, 32401 Neighboring gene predicted gene, 32184 Neighboring gene STARR-positive B cell enhancer ABC_E7229 Neighboring gene STARR-positive B cell enhancer ABC_E5388 Neighboring gene STARR-seq mESC enhancer starr_34304 Neighboring gene STARR-positive B cell enhancer ABC_E4066 Neighboring gene STARR-positive B cell enhancer mm9_chr13:41733437-41733738 Neighboring gene VISTA enhancer mm192 Neighboring gene predicted gene 5082 Neighboring gene predicted gene, 40925

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
  5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 170B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163572.2 → NP_001157044.1  transmembrane protein 170B isoform 1

    See identical proteins and their annotated locations for NP_001157044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC133159, AC154848
    Consensus CDS
    CCDS49248.1
    UniProtKB/Swiss-Prot
    P86050
    Related
    ENSMUSP00000131144.2, ENSMUST00000129449.3
    Conserved Domains (1) summary
    pfam10190
    Location:28 → 132
    Tmemb_170; Putative transmembrane protein 170

  2. NM_001368686.1 → NP_001355615.1  transmembrane protein 170B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133159, AC154848
    Consensus CDS
    CCDS88445.1
    UniProtKB/TrEMBL
    A0A1Y7VMZ7
    Related
    ENSMUSP00000152170.2, ENSMUST00000221694.2
    Conserved Domains (1) summary
    pfam10190
    Location:31 → 75
    Tmemb_170; Putative transmembrane protein 170

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    41759358..41794830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P86050.1 GenPept UniProtKB/Swiss-Prot:P86050

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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