MBP myelin basic protein [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: MBPprovided by VGNC
Official Full Name: myelin basic proteinprovided by VGNC
Primary source: VGNC:VGNC:54450
See related: BGD:BT11776; Ensembl:ENSBTAG00000022890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	24	NC_037351.1 (2224135..2328579)

Chromosome 24 - NC_037351.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The most relevant down regulated protein in lame dairy cows was myelin basic protein.
Title: Proteomic profiling of proteins in the dorsal horn of the spinal cord in dairy cows with chronic lameness.
Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.
Title: Deimination of the myelin basic protein decelerates its proteasome-mediated metabolism.
Data suggest that hybrid protein composed of two different Myelin basic protein (MBP) isoforms (TandeMBP) might become a tool for in vitro assays to analyse various protein kinase activities.
Title: TandeMBP: generation of a unique protein substrate for protein kinase assays.
trehalose completely avoid autocatalytic cleavage properties of MBP up to 4 days of incubation at 37 degrees C and pH 7.4.
Title: Myelin basic protein: structural characterization of spherulites formation and preventive action of trehalose.
formation of an imine between inflammatory-derived aldehydes can lead to structural changes in MBP and a decrease in myelin stability
Title: Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope.
results provide a detailed picture of the MBP-CaM interaction, including a 3D model of the complex between full-length proteins
Title: Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule.
MBP can induce a dihydrocholesterol-dependent segregation of phases that can be further regulated by the electrolyte concentration in the subphase and the composition (type and proportion) of non-sterol lipids.
Title: Micron-scale phase segregation in lipid monolayers induced by myelin basic protein in the presence of a cholesterol analog.
Bovine MBP priming reduces expression of Foxp3 via nitric oxide in inducible nitric oxide synthase-deficient mouse T cells.
Title: Myelin basic protein priming reduces the expression of Foxp3 in T cells via nitric oxide.
These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated high phosphorylation of SH-binding proteins, including MBP and tau protein.
Title: Biochemical characterization of phospholipids, sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin basic protein in vitro.
Myelin basic protein (MBP), a major autoantigen in multiple sclerosis, is a potent and specific ligand for integrin alphaMbeta2 expressed mainly on phagocytic cells.
Title: Structural insight into the function of myelin basic protein as a ligand for integrin alpha M beta 2.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

AF018092 (e-PCR)
- UniSTS:105087

UWCA72A (e-PCR), detects polymorphism
- UniSTS:279700

18cl11 (e-PCR)
- UniSTS:519341

UW72 (e-PCR)
- UniSTS:253638

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables structural constituent of myelin sheath	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in myelination	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IEA Inferred from Electronic Annotation more info	PubMed
located_in compact myelin	IEA Inferred from Electronic Annotation more info	PubMed
located_in internode region of axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: myelin basic protein

Names: 20 kDa microtubule-stabilizing protein; microtubule-stabilizing protein; myelin A1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.