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NUDT12 nudix hydrolase 12 [ Bos taurus (domestic cattle) ]

Gene ID: 617720, updated on 4-Oct-2024

Summary

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Official Symbol
NUDT12provided by VGNC
Official Full Name
nudix hydrolase 12provided by VGNC
Primary source
VGNC:VGNC:32326
See related
Ensembl:ENSBTAG00000027728
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NUDT12 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (102607081..102621172, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101906022 Neighboring gene uncharacterized LOC132345850 Neighboring gene uncharacterized LOC101905838 Neighboring gene transfer RNA tryptophan (anticodon CCA)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC137455

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADH pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in NADH metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in NADP catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NAD-capped RNA hydrolase NUDT12
Names
NADH pyrophosphatase NUDT12
deNADding enzyme NUDT12
nucleoside diphosphate-linked moiety X motif 12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
nudix motif 12
nudix-type motif 12
peroxisomal NADH pyrophosphatase NUDT12
NP_001040073.1
XP_005209829.1
XP_005209830.1
XP_005209831.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001046608.2 → NP_001040073.1  NAD-capped RNA hydrolase NUDT12

    See identical proteins and their annotated locations for NP_001040073.1

    Status: PROVISIONAL

    Source sequence(s)
    BC114173
    UniProtKB/Swiss-Prot
    Q29RH3
    Conserved Domains (4) summary
    COG2816
    Location:108 → 437
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd03429
    Location:305 → 439
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:130 → 259
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:261 → 284
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    102607081..102621172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005209773.5 → XP_005209830.1  NAD-capped RNA hydrolase NUDT12 isoform X1

    See identical proteins and their annotated locations for XP_005209830.1

    UniProtKB/TrEMBL
    A0AAF6ZDK8
    Conserved Domains (7) summary
    COG2816
    Location:126 → 455
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:16 → 98
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:323 → 457
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:148 → 277
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:279 → 302
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:31 → 86
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:16 → 43
    ANK; ANK repeat [structural motif]

  2. XM_005209772.5 → XP_005209829.1  NAD-capped RNA hydrolase NUDT12 isoform X1

    See identical proteins and their annotated locations for XP_005209829.1

    UniProtKB/TrEMBL
    A0AAF6ZDK8
    Related
    ENSBTAP00000039749.5, ENSBTAT00000039965.6
    Conserved Domains (7) summary
    COG2816
    Location:126 → 455
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:16 → 98
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:323 → 457
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:148 → 277
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:279 → 302
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:31 → 86
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:16 → 43
    ANK; ANK repeat [structural motif]

  3. XM_005209774.5 → XP_005209831.1  NAD-capped RNA hydrolase NUDT12 isoform X1

    See identical proteins and their annotated locations for XP_005209831.1

    UniProtKB/TrEMBL
    A0AAF6ZDK8
    Conserved Domains (7) summary
    COG2816
    Location:126 → 455
    NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
    cd00204
    Location:16 → 98
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03429
    Location:323 → 457
    NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
    pfam09296
    Location:148 → 277
    NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
    pfam09297
    Location:279 → 302
    zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain
    pfam13857
    Location:31 → 86
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:16 → 43
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29RH3.1 GenPept UniProtKB/Swiss-Prot:Q29RH3

Gene LinkOut

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