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RPL38 ribosomal protein L38 [ Homo sapiens (human) ]

Gene ID: 6169, updated on 7-Apr-2024

Summary

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Official Symbol
RPL38provided by HGNC
Official Full Name
ribosomal protein L38provided by HGNC
Primary source
HGNC:HGNC:10349
See related
Ensembl:ENSG00000172809 MIM:604182; AllianceGenome:HGNC:10349
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L38; eL38
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 645.4), fat (RPKM 429.7) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RPL38 in Genome Data Viewer
Location:
17q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74203678..74210655)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75094516..75101493)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72199817..72206794)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985081 Neighboring gene uncharacterized LOC105371888 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:71970489-71971186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71969789-71970488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:71983339-71984178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72001833-72002829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72005404-72005904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72037304-72037804 Neighboring gene long intergenic non-protein coding RNA 2074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72076663-72077162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72076161-72076662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72145665-72146166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72147681-72148235 Neighboring gene NANOG hESC enhancer GRCh37_chr17:72159526-72160027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72176106-72176682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72178385-72178885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72192568-72193068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72193069-72193569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72199053-72199556 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72200565-72201069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72201070-72201573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72220111-72220644 Neighboring gene uncharacterized protein MGC16275 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:72241021-72241915 Neighboring gene tweety family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72280764-72281359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72285237-72285737 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:72292700-72292934 Neighboring gene uncharacterized LOC105371891 Neighboring gene dynein axonemal intermediate chain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the Translational Efficiency of Specific Genes. Gopanenko AV, et al. Int J Mol Sci, 2021 Apr 26. PMID 33926116, Free PMC Article
  2. Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription. Gopanenko AV, et al. Biochimie, 2021 May. PMID 33675855
  3. Primary sequence of the human, lysine-rich, ribosomal protein RPL38 and detection of an unusual RPL38 processed pseudogene in the promoter region of the type-1 angiotensin II receptor gene. Espinosa L, et al. Biochim Biophys Acta, 1997 Oct 9. PMID 9375793
  4. Characterization of the proteome, diseases and evolution of the human postsynaptic density. Bayés A, et al. Nat Neurosci, 2011 Jan. PMID 21170055, Free PMC Article
  5. A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. Uechi T, et al. Genomics, 2001 Mar 15. PMID 11401437

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and bioinformatics analysis of RPL38 protein and mRNA in gastric cancer.
    Title: Expression and bioinformatics analysis of RPL38 protein and mRNA in gastric cancer.
  2. Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription.
    Title: Knockdown of the mRNA encoding the ribosomal protein eL38 in mammalian cells causes a substantial reorganization of genomic transcription.
  3. Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the Translational Efficiency of Specific Genes.
    Title: Knockdown of the Ribosomal Protein eL38 in HEK293 Cells Changes the Translational Efficiency of Specific Genes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in 90S preribosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in axial mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-RNA complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
  
involved_in skeletal system development IEA
Inferred from Electronic Annotation
more info
  
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic 80S initiation complex IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion HDA PubMed 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL38
Names
60S ribosomal protein L38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000999.4 → NP_000990.1  large ribosomal subunit protein eL38

    See identical proteins and their annotated locations for NP_000990.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer and predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100786, BQ276548, CB124619, Z26876
    Consensus CDS
    CCDS11696.1
    UniProtKB/Swiss-Prot
    B2R5A8, P23411, P63173
    UniProtKB/TrEMBL
    J3QL01
    Related
    ENSP00000309830.6, ENST00000311111.11
    Conserved Domains (1) summary
    pfam01781
    Location:2 → 68
    Ribosomal_L38e; Ribosomal L38e protein family

  2. NM_001035258.2 → NP_001030335.1  large ribosomal subunit protein eL38

    See identical proteins and their annotated locations for NP_001030335.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the shorter transcript, lacking a segment in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC100786, CB128529
    Consensus CDS
    CCDS11696.1
    UniProtKB/Swiss-Prot
    B2R5A8, P23411, P63173
    UniProtKB/TrEMBL
    J3QL01
    Related
    ENSP00000390279.2, ENST00000439590.6
    Conserved Domains (1) summary
    pfam01781
    Location:2 → 68
    Ribosomal_L38e; Ribosomal L38e protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74203678..74210655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75094516..75101493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63173.2 GenPept UniProtKB/Swiss-Prot:P63173

Gene LinkOut

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