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RPL37A ribosomal protein L37a [ Homo sapiens (human) ]

Gene ID: 6168, updated on 11-Apr-2024

Summary

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Official Symbol
RPL37Aprovided by HGNC
Official Full Name
ribosomal protein L37aprovided by HGNC
Primary source
HGNC:HGNC:10348
See related
Ensembl:ENSG00000197756 MIM:613314; AllianceGenome:HGNC:10348
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L37A; eL43
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 975.8), fat (RPKM 601.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RPL37A in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216498844..216504086)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216981257..216986499)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217363567..217368809)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene SMARCAL1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 13820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17096 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217339556-217340056 Neighboring gene RPL37A divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17100 Neighboring gene uncharacterized LOC101928156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217390604-217391496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17101 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:217417655-217418166 Neighboring gene uncharacterized LOC101928180 Neighboring gene uncharacterized LOC105373871 Neighboring gene uncharacterized LOC124907976

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human ribosomal protein L37a: cloning of the cDNA and analysis of differential gene expression in tissues and cell lines. Saha DP, et al. Gene, 1993 Oct 15. PMID 8224875
  2. Primary sequence of the human ribosomal protein L37a. Hoof T, et al. Nucleic Acids Res, 1992 Oct 25. PMID 1437567, Free PMC Article
  3. Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation. Passos DO, et al. FEBS J, 2006 Sep. PMID 16879614
  4. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Zhang C, et al. Proc Natl Acad Sci U S A, 2015 Dec 15. PMID 26631746, Free PMC Article
  5. Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. Wang X, et al. Dev Dyn, 2008 Oct. PMID 18816836, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL37A as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13357, MGC74786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL43
Names
60S ribosomal protein L37a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000998.5 → NP_000989.1  large ribosomal subunit protein eL43

    See identical proteins and their annotated locations for NP_000989.1

    Status: REVIEWED

    Source sequence(s)
    AC073321, BC014262, CD249666, L06499
    Consensus CDS
    CCDS2404.1
    UniProtKB/Swiss-Prot
    P12751, P61513, Q6FGF5
    Related
    ENSP00000418082.1, ENST00000491306.6
    Conserved Domains (1) summary
    pfam01780
    Location:4 → 88
    Ribosomal_L37ae; Ribosomal L37ae protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    216498844..216504086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    216981257..216986499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61513.2 GenPept UniProtKB/Swiss-Prot:P61513

Gene LinkOut

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