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RPL31 ribosomal protein L31 [ Homo sapiens (human) ]

Gene ID: 6160, updated on 3-Nov-2024

Summary

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Official Symbol
RPL31provided by HGNC
Official Full Name
ribosomal protein L31provided by HGNC
Primary source
HGNC:HGNC:10334
See related
Ensembl:ENSG00000071082 MIM:617415; AllianceGenome:HGNC:10334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L31; eL31
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 450.2), bone marrow (RPKM 284.8) and 25 other tissues See more
Orthologs
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Genomic context

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See RPL31 in Genome Data Viewer
Location:
2q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (101002289..101019724)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (101460986..101478421)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101618751..101636186)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373508 Neighboring gene neuronal PAS domain protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101504140-101504909 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:101518843-101520042 Neighboring gene Sharpr-MPRA regulatory region 12407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101599407-101599908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101599909-101600408 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:101601340-101601535 Neighboring gene NPAS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101607367-101608009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101611812-101612312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16296 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101619087-101619741 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:101621211-101621711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16297 Neighboring gene ubiquitin specific peptidase 15 pseudogene Neighboring gene uncharacterized LOC105373510 Neighboring gene TBC1 domain family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:101661499-101662000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:101663058-101663602 Neighboring gene BBSome interacting protein 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a human ribosomal protein mRNA with increased expression in colorectal tumours. Chester KA, et al. Biochim Biophys Acta, 1989 Dec 22. PMID 2597680
  2. cDNA sequence of human ribosomal protein L31. Nobori T, et al. Nucleic Acids Res, 1989 Sep 12. PMID 2780320, Free PMC Article
  3. Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis. Farrar JE, et al. Am J Hematol, 2014 Oct. PMID 25042156, Free PMC Article
  4. Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway. Maruyama Y, et al. PLoS One, 2014. PMID 25285958, Free PMC Article
  5. Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1. Sharen G, et al. J Transl Med, 2022 Oct 29. PMID 36309731, Free PMC Article

See all (219) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1.
    Title: Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1.
  2. protein levels of the tumor suppressor p53 and its targets, p21 and MDM2, were increased in LNCaP and bicalutamide-resistant LNCaP cells treated with RPL31 siRNA.
    Title: Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway.
  3. gene discovery in DBA, resulting in the identification of RPL31 as a novel DBA gene.
    Title: Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC88191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in focal adhesion HDA PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL31
Names
60S ribosomal protein L31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000993.5 → NP_000984.1  large ribosomal subunit protein eL31 isoform 1

    See identical proteins and their annotated locations for NP_000984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AC016738, BC017343, BC070373, DA869102
    Consensus CDS
    CCDS2049.1
    UniProtKB/Swiss-Prot
    B7Z4K2, D3DVJ4, P12947, P62899, Q53SQ5, Q6IRZ0, Q6LBJ6
    UniProtKB/TrEMBL
    B2R4C1
    Related
    ENSP00000264258.3, ENST00000264258.8
    Conserved Domains (1) summary
    pfam01198
    Location:19 → 100
    Ribosomal_L31e; Ribosomal protein L31e

  2. NM_001098577.3 → NP_001092047.1  large ribosomal subunit protein eL31 isoform 2

    See identical proteins and their annotated locations for NP_001092047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate terminal exon; the resulting isoform (2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC016738, BE564858, CN269912, CN269915, DA869102
    Consensus CDS
    CCDS46373.1
    UniProtKB/TrEMBL
    C9JU56
    Related
    ENSP00000386717.3, ENST00000409028.8
    Conserved Domains (1) summary
    pfam01198
    Location:19 → 100
    Ribosomal_L31e; Ribosomal protein L31e

  3. NM_001099693.2 → NP_001093163.1  large ribosomal subunit protein eL31 isoform 3

    See identical proteins and their annotated locations for NP_001093163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an unspliced 3' sequence compared to variant 1; the resulting isoform (3) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC070210, DA869102
    Consensus CDS
    CCDS46374.1
    UniProtKB/TrEMBL
    C9JU56
    Related
    ENSP00000387163.3, ENST00000409320.7
    Conserved Domains (1) summary
    pfam01198
    Location:19 → 100
    Ribosomal_L31e; Ribosomal protein L31e

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    101002289..101019724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    101460986..101478421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62899.1 GenPept UniProtKB/Swiss-Prot:P62899

Gene LinkOut

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