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HMGB3 high mobility group box 3 [ Bos taurus (domestic cattle) ]

Gene ID: 613729, updated on 10-Oct-2024

Summary

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Gene symbol
HMGB3
Gene description
high mobility group box 3
See related
BGD:BT17434; Ensembl:ENSBTAG00000005150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See HMGB3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (33603508..33611398)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 1 Neighboring gene CD99 molecule like 2 Neighboring gene G protein-coupled receptor 50 Neighboring gene vacuolar ATPase assembly factor VMA21

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple promoters and targeted microRNAs direct the expressions of HMGB3 gene transcripts in dairy cattle. Li L, et al. Anim Genet, 2013 Jun. PMID 23206268
  2. The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. Paull TT, et al. Genes Dev, 1993 Aug. PMID 8339930
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC133786

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding, bending IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
high mobility group protein B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076285.2 → NP_001069753.2  high mobility group protein B3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC109793, DN519356, EV609191
    UniProtKB/TrEMBL
    A0A452DI06
    Related
    ENSBTAP00000005793.7, ENSBTAT00000005793.7
    Conserved Domains (2) summary
    pfam00505
    Location:167 → 234
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:87 → 152
    HMG_box_2; HMG-box domain

  2. NM_001113257.2 → NP_001106728.1  high mobility group protein B3 isoform 2

    See identical proteins and their annotated locations for NP_001106728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    DN519356, EE334754
    UniProtKB/Swiss-Prot
    Q32L31
    UniProtKB/TrEMBL
    E1BIU3, I7FVA7
    Conserved Domains (2) summary
    pfam00505
    Location:93 → 160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:13 → 78
    HMG_box_2; HMG-box domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    33603508..33611398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059883525.1 → XP_059739508.1  high mobility group protein B3 isoform X2

  2. XM_059883524.1 → XP_059739507.1  high mobility group protein B3 isoform X1

    UniProtKB/Swiss-Prot
    Q32L31
    UniProtKB/TrEMBL
    I7FVA7

  3. XM_024988207.2 → XP_024843975.1  high mobility group protein B3 isoform X1

    UniProtKB/Swiss-Prot
    Q32L31
    UniProtKB/TrEMBL
    E1BIU3, I7FVA7
    Conserved Domains (2) summary
    pfam00505
    Location:93 → 160
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:13 → 78
    HMG_box_2; HMG-box domain

  4. XM_024988206.2 → XP_024843974.1  high mobility group protein B3 isoform X3

    UniProtKB/TrEMBL
    A0A452DI18, E1BIU3
    Related
    ENSBTAP00000006785.7, ENSBTAT00000006785.7
    Conserved Domains (2) summary
    pfam00505
    Location:97 → 164
    HMG_box; HMG (high mobility group) box
    pfam09011
    Location:17 → 82
    HMG_box_2; HMG-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32L31.2 GenPept UniProtKB/Swiss-Prot:Q32L31

Gene LinkOut

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