U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

c1r complement C1r [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 613057, updated on 4-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
c1rprovided by Xenbase
Official Full Name
complement C1rprovided by Xenbase
Primary source
Xenbase:XB-GENE-995376
See related
Ensembl:ENSXETG00000033339 AllianceGenome:Xenbase:XB-GENE-995376
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
c1rl
Summary
Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and proteolysis. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 1. Orthologous to several human genes including C1R (complement C1r). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See c1r in Genome Data Viewer
Location:
chromosome: 7
Exon count:
22
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (9267188..9297548, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (894743..934835, complement)

Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene complement C1r-A subcomponent-like Neighboring gene complement C1s Neighboring gene retinol binding protein 5 Neighboring gene calsyntenin 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within complement activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
complement C1r; complement C1r subcomponent
Names
complement component 1, r subcomponent

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    9267188..9297548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002941214.5 → XP_002941260.2  complement C1r subcomponent isoform X3

    UniProtKB/TrEMBL
    A0A8J0QXY3, F7ECI2
    Related
    ENSXETP00000051584.4, ENSXETT00000051584.4
    Conserved Domains (7) summary
    cd00033
    Location:370 → 437
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:452 → 693
    Tryp_SPc; Trypsin-like serine protease
    smart00032
    Location:304 → 365
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    smart00042
    Location:25 → 134
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00041
    Location:188 → 299
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:453 → 695
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam14670
    Location:156 → 184
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_031906088.1 → XP_031761948.1  complement C1r subcomponent isoform X2

    UniProtKB/TrEMBL
    A0A6I8PUA6, A0A8J1JVN6
    Related
    ENSXETP00000058638.3, ENSXETT00000065317.3
    Conserved Domains (6) summary
    PHA02639
    Location:322 → 485
    PHA02639; EEV host range protein; Provisional
    smart00042
    Location:24 → 133
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:453 → 695
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:303 → 365
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:187 → 296
    CUB; CUB domain
    pfam14670
    Location:155 → 183
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_002941209.3 → XP_002941255.1  complement C1r subcomponent isoform X1

    UniProtKB/TrEMBL
    A0A6I8S4A6, A0A8J0QSW6
    Related
    ENSXETP00000088063.2, ENSXETT00000099947.2
    Conserved Domains (7) summary
    cd00033
    Location:370 → 424
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00020
    Location:452 → 700
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:24 → 133
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:453 → 702
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:303 → 365
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:187 → 296
    CUB; CUB domain
    pfam14670
    Location:155 → 183
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.