CTSA cathepsin A [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CTSAprovided by VGNC
Official Full Name: cathepsin Aprovided by VGNC
Primary source: VGNC:VGNC:39708
See related: Ensembl:ENSCAFG00845016332
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: PPGB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	24	NC_051828.1 (33893407..33899565)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	24	NC_006606.4 (32710110..32716269)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	24	NC_049245.1 (33806176..33812343)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	24	NC_049284.1 (33151886..33158036)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	24	NC_049765.1 (33267003..33273167)

Chromosome 24 - NC_051828.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leptin Modulates the Metastasis of Canine Inflammatory Mammary Adenocarcinoma Cells Through Downregulation of Lysosomal Protective Protein Cathepsin A (CTSA).
Title: Leptin Modulates the Metastasis of Canine Inflammatory Mammary Adenocarcinoma Cells Through Downregulation of Lysosomal Protective Protein Cathepsin A (CTSA).
This is the first study that simultaneously examine the effect of GLB1(+/+), GLB1(+/-) and GLB1(-/-) genotypes on the expression of lysosomal multienzyme complex components.
Title: Impact of beta-galactosidase mutations on the expression of the canine lysosomal multienzyme complex.

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General gene information

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Markers

MARC_41166-41167:1085775548:1 (e-PCR)
- UniSTS:471588

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type carboxypeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lysosomal protective protein

Names: beta-galactosidase protective protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109915.2 → NP_001103385.2 lysosomal protective protein precursor

Status: PROVISIONAL

Source sequence(s)

JAAUVH010000376

UniProtKB/TrEMBL

A0A8I3RZ95

Related

ENSCAFP00845022850.1, ENSCAFT00845029051.1

Conserved Domains (1) summary

pfam00450
Location:58 → 495

Peptidase_S10; Serine carboxypeptidase