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NAE1 NEDD8 activating enzyme E1 subunit 1 [ Canis lupus familiaris (dog) ]

Gene ID: 610026, updated on 17-Aug-2024

Summary

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Official Symbol
NAE1provided by VGNC
Official Full Name
NEDD8 activating enzyme E1 subunit 1provided by VGNC
Primary source
VGNC:VGNC:43607
See related
Ensembl:ENSCAFG00845011147
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
APPBP1
Orthologs
human mouse all
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Genomic context

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See NAE1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (82899329..82922733)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (82451391..82474791)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (83048382..83071880)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (82722479..82745880)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (82409395..82433102)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase phosphatase catalytic subunit 2 Neighboring gene carbonic anhydrase 7 Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene dynein cytoplasmic 1 light intermediate chain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NEDD8 activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NEDD8-activating enzyme E1 regulatory subunit
Names
amyloid beta precursor protein binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    82899329..82922733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038667455.1 → XP_038523383.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

    UniProtKB/TrEMBL
    A0A8C0T7P5, A0A8I3RYG1
    Related
    ENSCAFP00845015513.1, ENSCAFT00845019817.1
    Conserved Domains (1) summary
    cd01493
    Location:11 → 532
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

  2. XM_038667457.1 → XP_038523385.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    UniProtKB/TrEMBL
    A0A8C0KZW2
    Conserved Domains (2) summary
    TIGR01408
    Location:306 → 409
    Ube1; ubiquitin-activating enzyme E1
    cl22428
    Location:18 → 428
    E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

  3. XM_038667456.1 → XP_038523384.1  NEDD8-activating enzyme E1 regulatory subunit isoform X2

    UniProtKB/TrEMBL
    A0A8C0N2C7
    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    TIGR01408
    Location:321 → 424
    Ube1; ubiquitin-activating enzyme E1

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    82722479..82745880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038477529.1 → XP_038333457.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

    Conserved Domains (1) summary
    cd01493
    Location:11 → 532
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

  2. XM_038477531.1 → XP_038333459.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    Conserved Domains (2) summary
    TIGR01408
    Location:306 → 409
    Ube1; ubiquitin-activating enzyme E1
    cl22428
    Location:18 → 428
    E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

  3. XM_038477530.1 → XP_038333458.1  NEDD8-activating enzyme E1 regulatory subunit isoform X2

    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    TIGR01408
    Location:321 → 424
    Ube1; ubiquitin-activating enzyme E1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    82409395..82433102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038602851.1 → XP_038458779.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

    Conserved Domains (1) summary
    cd01493
    Location:11 → 532
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

  2. XM_038602853.1 → XP_038458781.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    Conserved Domains (2) summary
    TIGR01408
    Location:306 → 409
    Ube1; ubiquitin-activating enzyme E1
    cl22428
    Location:18 → 428
    E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

  3. XM_038602852.1 → XP_038458780.1  NEDD8-activating enzyme E1 regulatory subunit isoform X2

    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    TIGR01408
    Location:321 → 424
    Ube1; ubiquitin-activating enzyme E1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    83048382..83071880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038538750.1 → XP_038394678.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

    UniProtKB/TrEMBL
    A0A8C0T7P5, A0A8I3RYG1
    Conserved Domains (1) summary
    cd01493
    Location:11 → 532
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

  2. XM_038538752.1 → XP_038394680.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    UniProtKB/TrEMBL
    A0A8C0KZW2
    Conserved Domains (2) summary
    TIGR01408
    Location:306 → 409
    Ube1; ubiquitin-activating enzyme E1
    cl22428
    Location:18 → 428
    E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

  3. XM_038538751.1 → XP_038394679.1  NEDD8-activating enzyme E1 regulatory subunit isoform X2

    UniProtKB/TrEMBL
    A0A8C0N2C7
    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    TIGR01408
    Location:321 → 424
    Ube1; ubiquitin-activating enzyme E1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    82451391..82474791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003639075.5 → XP_003639123.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

    UniProtKB/TrEMBL
    A0A8C0T7P5, A0A8I3RYG1
    Conserved Domains (1) summary
    cd01493
    Location:11 → 532
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

  2. XM_038531266.1 → XP_038387194.1  NEDD8-activating enzyme E1 regulatory subunit isoform X3

    UniProtKB/TrEMBL
    A0A8C0KZW2
    Conserved Domains (2) summary
    TIGR01408
    Location:306 → 409
    Ube1; ubiquitin-activating enzyme E1
    cl22428
    Location:18 → 428
    E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

  3. XM_022419396.1 → XP_022275104.1  NEDD8-activating enzyme E1 regulatory subunit isoform X2

    UniProtKB/TrEMBL
    A0A8C0N2C7
    Conserved Domains (2) summary
    cd01493
    Location:1 → 443
    APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    TIGR01408
    Location:321 → 424
    Ube1; ubiquitin-activating enzyme E1
Nucleotide Protein
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