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JUN Jun proto-oncogene, AP-1 transcription factor subunit [ Canis lupus familiaris (dog) ]

Gene ID: 609429, updated on 17-Aug-2024

Summary

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Official Symbol
JUNprovided by VGNC
Official Full Name
Jun proto-oncogene, AP-1 transcription factor subunitprovided by VGNC
Primary source
VGNC:VGNC:42197
See related
Ensembl:ENSCAFG00845006541
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
AP-1; c-jun
Orthologs
human mouse all
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Genomic context

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See JUN in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (51147773..51149113)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (51033459..51034786)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (51326980..51328311)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (51098106..51099438)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (51043349..51044688)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102155586 Neighboring gene uncharacterized LOC119872023 Neighboring gene uncharacterized LOC102155678 Neighboring gene Myb like, SWIRM and MPN domains 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes. Bwalya EC, et al. PLoS One, 2017. PMID 28472120, Free PMC Article
  2. Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression. Ray A, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16380175
  3. Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation. Ikari A, et al. Biochim Biophys Acta, 2013 Dec. PMID 23816505
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrate for the first time that PPS is a novel inhibitor of IL-1beta-induced iNOS, c-Jun, and HIF-1alpha mRNA upregulation and iNOS protein induction which may be beneficial for prevention and treatment OA
    Title: Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes.
  2. hyperosmolarity increases nuclear Sp1/c-Jun complex and the association of the complex with the Sp1 binding site, resulting in the segment-specific expression of claudin-4 in the kidney.
    Title: Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation.
  3. results show that induction and activation of AP-1 and SAF-1 transcription factors are involved in the regulation of MMP-1 expression in the chondrocytes
    Title: Inflammation-responsive transcription factors SAF-1 and c-Jun/c-Fos promote canine MMP-1 gene expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcription factor AP-1
Names
jun oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    51147773..51149113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038666089.1 → XP_038522017.1  transcription factor AP-1

    UniProtKB/TrEMBL
    A0A8C0R052, A0A8C0Z0Z1, A0A8I3RTD9, A0A8P0TN96
    Related
    ENSCAFP00845009067.1, ENSCAFT00845011604.1
    Conserved Domains (2) summary
    cd14696
    Location:264 → 324
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5 → 251
    Jun; Jun-like transcription factor

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    51098106..51099438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038476209.1 → XP_038332137.1  transcription factor AP-1

    Conserved Domains (2) summary
    cd14696
    Location:264 → 324
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5 → 251
    Jun; Jun-like transcription factor

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    51043349..51044688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038601523.1 → XP_038457451.1  transcription factor AP-1

    Conserved Domains (2) summary
    cd14696
    Location:264 → 324
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5 → 251
    Jun; Jun-like transcription factor

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    51326980..51328311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038537394.1 → XP_038393322.1  transcription factor AP-1

    UniProtKB/TrEMBL
    A0A8I3RTD9, A0A8P0TN96

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    51033459..51034786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005620245.4 → XP_005620302.1  transcription factor AP-1

    UniProtKB/TrEMBL
    A0A8C0R052, A0A8C0Z0Z1, A0A8I3RTD9, A0A8P0TN96
    Conserved Domains (2) summary
    cd14696
    Location:264 → 324
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5 → 251
    Jun; Jun-like transcription factor
Nucleotide Protein
Heading Accession and Version

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