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ATG101 autophagy related 101 [ Homo sapiens (human) ]

Gene ID: 60673, updated on 3-Apr-2024

Summary

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Official Symbol
ATG101provided by HGNC
Official Full Name
autophagy related 101provided by HGNC
Primary source
HGNC:HGNC:25679
See related
Ensembl:ENSG00000123395 MIM:615089; AllianceGenome:HGNC:25679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf44
Summary
Enables identical protein binding activity. Involved in autophagosome assembly. Located in phagophore assembly site. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 16.2), thyroid (RPKM 14.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ATG101 in Genome Data Viewer
Location:
12q13.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52065300..52077495)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52028879..52041075)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (52463762..52471279)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 4 group A member 1 Neighboring gene uncharacterized LOC107984510 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52445362-52445919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6389 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:52463395-52464110 Neighboring gene NR4A1 antisense RNA Neighboring gene uncharacterized LOC112268096 Neighboring gene small integral membrane protein 41 Neighboring gene olfactory receptor family 7 subfamily E member 47 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6393 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52524285-52524822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52537787-52538604 Neighboring gene Sharpr-MPRA regulatory region 3292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:52543503-52544317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4483 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:52577352-52578177 Neighboring gene keratin 80

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma. Wang B, et al. Sci Rep, 2022 Oct 27. PMID 36302799, Free PMC Article
  2. Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. Qi S, et al. Structure, 2015 Oct 6. PMID 26299944, Free PMC Article
  3. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Mercer CA, et al. Autophagy, 2009 Jul. PMID 19287211
  4. Structure of the Atg101-Atg13 complex reveals essential roles of Atg101 in autophagy initiation. Suzuki H, et al. Nat Struct Mol Biol, 2015 Jul. PMID 26030876
  5. Autophagic Flux Is Regulated by Interaction Between the C-terminal Domain of PATCHED1 and ATG101. Chen X, et al. Mol Cancer Res, 2018 May. PMID 29453315, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.
    Title: The role of the HORMA domain proteins ATG13 and ATG101 in initiating autophagosome biogenesis.
  2. ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma.
    Title: ATG101-related signature predicts prognosis and therapeutic option in hepatocellular carcinoma.
  3. ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.
    Title: ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.
  4. The C-terminal deletion of ATG101 shows a significant defect in the interaction with PtdIns3K components and subsequently impairs autophagosome formation. This result clearly presents an additional role of ATG101 for bridging the ULK1 and PtdIns3K complexes in the mammalian autophagy process.
    Title: The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation.
  5. Structure of the human Atg13-Atg101 HORMA heterodimer in the ULK1 complex that controls autophagy has been described.
    Title: Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.
  6. Data indicate mitogen lacritin stimulates FOXO3-ATG101 and FOXO1-ATG7 autophagic coupling and restores metabolic homeostasis.
    Title: Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.
  7. These data suggest that Atg101 is a novel Atg protein that functions together with ULK, Atg13 and FIP200.
    Title: Atg101, a novel mammalian autophagy protein interacting with Atg13.
  8. The identification of the novel protein, Atg101, and the validation of Atg13 and Atg101 as ULK1-interacting proteins, suggests an Atg1 complex is involved in the induction of macroautophagy in mammalian cells.
    Title: A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11773

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein lipidation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Atg1/ULK1 kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Atg1/ULK1 kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
autophagy-related protein 101
Names
Atg13-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098673.2 → NP_001092143.1  autophagy-related protein 101

    See identical proteins and their annotated locations for NP_001092143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC005151, BP309508, CB137838
    Consensus CDS
    CCDS8820.1
    UniProtKB/Swiss-Prot
    Q9BSB4, Q9HAE2, Q9HBN1
    UniProtKB/TrEMBL
    F8VQD9
    Related
    ENSP00000450088.1, ENST00000553049.5
    Conserved Domains (1) summary
    pfam07855
    Location:9 → 172
    ATG101; Autophagy-related protein 101

  2. NM_021934.5 → NP_068753.2  autophagy-related protein 101

    See identical proteins and their annotated locations for NP_068753.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC025259
    Consensus CDS
    CCDS8820.1
    UniProtKB/Swiss-Prot
    Q9BSB4, Q9HAE2, Q9HBN1
    UniProtKB/TrEMBL
    F8VQD9
    Related
    ENSP00000338990.4, ENST00000336854.9
    Conserved Domains (1) summary
    pfam07855
    Location:9 → 172
    ATG101; Autophagy-related protein 101

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    52065300..52077495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449120.2 → XP_024304888.1  autophagy-related protein 101 isoform X1

    UniProtKB/Swiss-Prot
    Q9BSB4, Q9HAE2, Q9HBN1
    UniProtKB/TrEMBL
    F8VQD9
    Conserved Domains (1) summary
    pfam07855
    Location:9 → 172
    ATG101; Autophagy-related protein 101

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    52028879..52041075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372827.1 → XP_054228802.1  autophagy-related protein 101 isoform X1

    UniProtKB/Swiss-Prot
    Q9BSB4, Q9HAE2, Q9HBN1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BSB4.1 GenPept UniProtKB/Swiss-Prot:Q9BSB4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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