dhx8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhx8provided by ZNC
Official Full Name: DEAH (Asp-Glu-Ala-His) box polypeptide 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-050809-39
See related: Ensembl:ENSDARG00000054707 AllianceGenome:ZFIN:ZDB-GENE-050809-39
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7153552
Summary: Predicted to enable RNA binding activity and RNA helicase activity. Acts upstream of or within cell division; mRNA splicing, via endonucleolytic cleavage and ligation; and primitive hemopoiesis. Located in nucleus. Is expressed in brain; midbrain; and pronephric duct. Orthologous to human DHX8 (DEAH-box helicase 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (27570447..27588344, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (27479085..27496996, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, our results confirm that dhx8 is involved in mRNA splicing and suggest that it is also important for cell division during mitosis.
Title: Incomplete splicing, cell division defects, and hematopoietic blockage in dhx8 mutant zebrafish.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

G45552 (e-PCR)
- UniSTS:106354

fa04a04.s1 (e-PCR)
- UniSTS:202182

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA splicing, via endonucleolytic cleavage and ligation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DHX8

XP_002663993.1

EC 3.6.4.13

XP_021336018.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

27570447..27588344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480343.2 → XP_021336018.1 ATP-dependent RNA helicase DHX8

UniProtKB/TrEMBL

A0A8M9Q925, E7F7E3

Related

ENSDARP00000066281.3, ENSDART00000066282.5

Conserved Domains (2) summary

COG1643
Location:542 → 1209

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd05684
Location:257 → 333

S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394847.1 Reference GRCz11 ALT_DRER_TU_1

Range

501297..519194 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002663947.6 → XP_002663993.1 ATP-dependent RNA helicase DHX8

UniProtKB/TrEMBL

A0A8M9Q925, E7F7E3

Conserved Domains (2) summary

COG1643
Location:542 → 1209

HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

cd05684
Location:257 → 333

S1_DHX8_helicase; S1_DHX8_helicase: The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced ...