U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dusp4 dual specificity phosphatase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60587, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Dusp4provided by RGD
Official Full Name
dual specificity phosphatase 4provided by RGD
Primary source
RGD:620625
See related
EnsemblRapid:ENSRNOG00000011921 AllianceGenome:RGD:620625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mkp2; Mkp-2
Summary
Enables MAP kinase tyrosine/serine/threonine phosphatase activity and protein tyrosine/threonine phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human DUSP4 (dual specificity phosphatase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 74.3), Adrenal (RPKM 72.0) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dusp4 in Genome Data Viewer
Location:
16q12.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (64079893..64101396, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (57376659..57398161, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (61080767..61090973, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693975 Neighboring gene uncharacterized LOC134482396 Neighboring gene tankyrase Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC120097484

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosis. Barajas-Espinosa A, et al. Free Radic Biol Med, 2014 Sep. PMID 24973647, Free PMC Article
  2. A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation. Misra-Press A, et al. J Biol Chem, 1995 Jun 16. PMID 7782322
  3. Dual Specificity Phosphatases Support Axon Plasticity and Viability. Chandrasekhar A, et al. Mol Neurobiol, 2021 Jan. PMID 32959171
  4. The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase. Edwards L, et al. Brain Res, 2003 Aug 1. PMID 12865160
  5. Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. Berasi SP, et al. J Biol Chem, 2006 Sep 15. PMID 16849326

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual Specificity Phosphatases Support Axon Plasticity and Viability.
    Title: Dual Specificity Phosphatases Support Axon Plasticity and Viability.
  2. DUSP4 gene knockdown further supports the hypothesis that DUSP4 is an antioxidant gene, critical in the modulation of eNOS expression, and thus protects against Cd(2+)-induced stress.
    Title: Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²⁺-induced apoptosis.
  3. The I(1)-imidazoline receptor in PC12 pheochromocytoma cells induces MKP-2 phosphatase.
    Title: The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase.
  4. the inhibition of hepatic gluconeogenesis by AMPK may, in part, be mediated by an immediate early gene response involving EGR1 and its target, DUSP4
    Title: Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity protein phosphatase 4
Names
MAP kinase phosphatase 2
mitogen-activated protein kinase phosphatase 2
NP_071535.2
XP_038950731.1
XP_063131752.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022199.2 → NP_071535.2  dual specificity protein phosphatase 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IVN4, G3V7L2
    Related
    ENSRNOP00000016328.1, ENSRNOT00000016328.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    64079893..64101396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094803.2 → XP_038950731.1  dual specificity protein phosphatase 4 isoform X1

    UniProtKB/Swiss-Prot
    Q62767
    UniProtKB/TrEMBL
    A6IVN4, G3V7L2
    Conserved Domains (2) summary
    cd01446
    Location:9 → 159
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14640
    Location:197 → 337
    DSP_DUSP4; dual specificity phosphatase domain of dual specificity protein phosphatase 4

  2. XM_063275682.1 → XP_063131752.1  dual specificity protein phosphatase 4 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62767.1 GenPept UniProtKB/Swiss-Prot:Q62767

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous