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Syt9 synaptotagmin IX [ Mus musculus (house mouse) ]

Gene ID: 60510, updated on 28-Oct-2024

Summary

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Official Symbol
Syt9provided by MGI
Official Full Name
synaptotagmin IXprovided by MGI
Primary source
MGI:MGI:1926373
See related
Ensembl:ENSMUSG00000062542 AllianceGenome:MGI:1926373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables SNARE binding activity; identical protein binding activity; and phospholipid binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion and regulation of calcium ion-dependent exocytosis. Located in dense core granule. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Is expressed in several structures, including adrenal gland; gonad; liver; nervous system; and spleen. Orthologous to human SYT9 (synaptotagmin 9). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in cerebellum adult (RPKM 9.2), CNS E18 (RPKM 4.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Syt9 in Genome Data Viewer
Location:
7 E3; 7 56.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (106969929..107147863)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (107370349..107548656)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19757 Neighboring gene RNA binding motif protein, X-linked-like 2 Neighboring gene STARR-seq mESC enhancer starr_19760 Neighboring gene STARR-seq mESC enhancer starr_19762 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19764 Neighboring gene STARR-positive B cell enhancer ABC_E8198 Neighboring gene STARR-positive B cell enhancer ABC_E1352 Neighboring gene olfactomedin-like 1 Neighboring gene STARR-seq mESC enhancer starr_19765 Neighboring gene PTPRF interacting protein, binding protein 2 (liprin beta 2) Neighboring gene STARR-seq mESC enhancer starr_19766 Neighboring gene STARR-positive B cell enhancer mm9_chr7:114807884-114808185 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:114846576-114846777 Neighboring gene STARR-seq mESC enhancer starr_19769 Neighboring gene cytochrome b5 reductase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons. Zhang M, et al. J Neurosci, 2023 Apr 26. PMID 36898834, Free PMC Article
  2. Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9. Roper LK, et al. Nat Commun, 2015 Oct 20. PMID 26482442, Free PMC Article
  3. A charged prominence in the linker domain of the cysteine-string protein Cspα mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis. Boal F, et al. FASEB J, 2011 Jan. PMID 20847230
  4. Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. Gustavsson N, et al. PLoS One, 2010 Nov 9. PMID 21085706, Free PMC Article
  5. Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance. Rahman MM, et al. FASEB J, 2023 Aug. PMID 37432648, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic beta-cells improving glucose clearance.
    Title: Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance.
  2. The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
    Title: The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
  3. Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.
    Title: Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.
  4. expressed in a subpopulation of anterior pituitary cells, the gonadotropes
    Title: Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9.
  5. Syt-9 interacted with APP in cells and in mouse brains in vivo, promoting Abeta generation.
    Title: Synaptotagmins interact with APP and promote Aβ generation.
  6. Data show that synaptotagmin-9 is not involved in the regulation of glucose-stimulated insulin release from pancreatic beta-cells.
    Title: Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion.
  7. Data indicate that Cspalpha interacts with Syt9, and such a complex may be relevant in the calcium-mediated control of a late stage of exocytosis by triggering the specific recruitment of a folding catalyst at the fusion point.
    Title: A charged prominence in the linker domain of the cysteine-string protein Cspα mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-dependent activation of synaptic vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dense core granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in synaptic vesicle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
synaptotagmin-9
Names
synaptotagmin V
sytIX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021889.5 → NP_068689.2  synaptotagmin-9

    See identical proteins and their annotated locations for NP_068689.2

    Status: VALIDATED

    Source sequence(s)
    AC127431, AC164638
    Consensus CDS
    CCDS40078.1
    UniProtKB/Swiss-Prot
    Q3U0R7, Q8C280, Q9R0N9
    Related
    ENSMUSP00000073164.6, ENSMUST00000073459.12
    Conserved Domains (2) summary
    cd08403
    Location:354 → 487
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    cl14603
    Location:221 → 345
    C2; C2 domain

RNA

  1. NR_184790.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127431, AC164638
    Related
    ENSMUST00000130414.8

  2. NR_184791.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127431, AC164638

  3. NR_184792.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127431, AC164638

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    106969929..107147863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0N9.2 GenPept UniProtKB/Swiss-Prot:Q9R0N9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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