fa2h fatty acid 2-hydroxylase [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: fa2hprovided by Xenbase
Official Full Name: fatty acid 2-hydroxylaseprovided by Xenbase
Primary source: Xenbase:XB-GENE-1014400
See related: Ensembl:ENSXETG00000007676 AllianceGenome:Xenbase:XB-GENE-1014400
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable fatty acid 2-hydroxylase activity; heme binding activity; and iron ion binding activity. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	4	NC_030680.2 (74643634..74679151)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	4	NC_030680.1 (26610523..26646072)

Chromosome 4 - NC_030680.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables fatty acid 2-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid 2-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty acid 2-hydroxylase

NP_001025677.1

EC 1.-.-.-

EC 1.14.18.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030506.1 → NP_001025677.1 fatty acid 2-hydroxylase

See identical proteins and their annotated locations for NP_001025677.1

Status: PROVISIONAL

Source sequence(s)

BC093464

UniProtKB/TrEMBL

F7EPE2, Q561P1

Related

ENSXETP00000016705.4, ENSXETT00000016705.5

Conserved Domains (2) summary

pfam00173
Location:7 → 80

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

cl01132
Location:124 → 367

FA_hydroxylase; Fatty acid hydroxylase superfamily