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Gpa33 glycoprotein A33 transmembrane [ Mus musculus (house mouse) ]

Gene ID: 59290, updated on 18-Sep-2024

Summary

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Official Symbol
Gpa33provided by MGI
Official Full Name
glycoprotein A33 transmembraneprovided by MGI
Primary source
MGI:MGI:1891703
See related
Ensembl:ENSMUSG00000000544 AllianceGenome:MGI:1891703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mA33; 2010310L10Rik; 2210401D16Rik
Summary
Located in plasma membrane. Is expressed in several structures, including blastocyst; gut; sensory organ; skeleton; and urogenital sinus. Orthologous to human GPA33 (glycoprotein A33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 349.7), large intestine adult (RPKM 252.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Gpa33 in Genome Data Viewer
Location:
1 H2.3; 1 73.49 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165957790..165994079)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (166130221..166166510)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm757 Neighboring gene predicted gene, 39693 Neighboring gene serine/threonine/tyrosine interacting like 2 Neighboring gene STARR-seq mESC enhancer starr_02920 Neighboring gene STARR-positive B cell enhancer ABC_E7772 Neighboring gene STARR-seq mESC enhancer starr_02926 Neighboring gene maelstrom spermatogenic transposon silencer Neighboring gene immunoglobulin-like domain containing receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease. Williams BB, et al. Dis Model Mech, 2015 Aug 1. PMID 26035389, Free PMC Article
  2. A33 antigen-deficient mice have defective colonic mucosal repair. Pereira-Fantini PM, et al. Inflamm Bowel Dis, 2010 Apr. PMID 19856415
  3. Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Orner GA, et al. Mutat Res, 2002 Sep 30. PMID 12351151
  4. The murine A33 antigen is expressed at two distinct sites during development, the ICM of the blastocyst and the intestinal epithelium. Abud HE, et al. Mech Dev, 2000 Nov. PMID 11044613
  5. Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Johnstone CN, et al. Am J Physiol Gastrointest Liver Physiol, 2000 Sep. PMID 10960348

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gpa33(-/-) mice provide a valuable model to study the mechanisms linking intestinal permeability and multiple inflammatory pathologies.
    Title: Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease.
  2. A33 antigen-deficient mice have defective colonic mucosal repair.
    Title: A33 antigen-deficient mice have defective colonic mucosal repair.
  3. cloning, chromosomal localizations, exon-intron structures and transcription start sites - target gene for the intestine-specific homeobox transcription factor, CDX1
    Title: Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Gene trapped (1) 
  • Targeted (9)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell surface A33 antigen
Names
A33 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360925.1 → NP_001347854.1  cell surface A33 antigen isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC034122, AC138358
    Conserved Domains (2) summary
    smart00408
    Location:46 → 110
    IGc2; Immunoglobulin C-2 Type
    pfam13908
    Location:123 → 154
    Shisa; Wnt and FGF inhibitory regulator

  2. NM_001360926.1 → NP_001347855.1  cell surface A33 antigen isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC138358, AK008784
    UniProtKB/TrEMBL
    Q9D7V7
    Related
    ENSMUST00000027847.7
    Conserved Domains (1) summary
    pfam07686
    Location:31 → 138
    V-set; Immunoglobulin V-set domain

  3. NM_021610.2 → NP_067623.1  cell surface A33 antigen isoform 1 precursor

    See identical proteins and their annotated locations for NP_067623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138358, AF247659
    Consensus CDS
    CCDS15447.1
    UniProtKB/Swiss-Prot
    Q922D5, Q9JKA5
    UniProtKB/TrEMBL
    A0A0R4J209
    Related
    ENSMUSP00000060147.8, ENSMUST00000060833.14
    Conserved Domains (4) summary
    smart00408
    Location:154 → 218
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:151 → 226
    IG_like; Immunoglobulin like
    pfam07686
    Location:31 → 138
    V-set; Immunoglobulin V-set domain
    pfam13908
    Location:240 → 262
    Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165957790..165994079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKA5.2 GenPept UniProtKB/Swiss-Prot:Q9JKA5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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