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RARRES1 retinoic acid receptor responder 1 [ Homo sapiens (human) ]

Gene ID: 5918, updated on 5-Mar-2024

Summary

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Official Symbol
RARRES1provided by HGNC
Official Full Name
retinoic acid receptor responder 1provided by HGNC
Primary source
HGNC:HGNC:9867
See related
Ensembl:ENSG00000118849 MIM:605090; AllianceGenome:HGNC:9867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LXNL; TIG1; PERG-1
Summary
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 33.7), urinary bladder (RPKM 25.5) and 17 other tissues See more
Orthologs
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Genomic context

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See RARRES1 in Genome Data Viewer
Location:
3q25.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (158696892..158732457, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (161470815..161506388, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158414681..158450246, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158344231-158344732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158344733-158345232 Neighboring gene RFK pseudogene 6 Neighboring gene G elongation factor mitochondrial 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:158389654-158390246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:158390247-158390839 Neighboring gene latexin Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:158430992-158432191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158433310-158433810 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:158447157-158447335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14848 Neighboring gene uncharacterized LOC100287290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158450198-158450698 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:158478422-158478617 Neighboring gene VISTA enhancer hs1990 Neighboring gene ribosomal protein L35a pseudogene 9 Neighboring gene major facilitator superfamily domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Autocrine and paracrine effects of a novel podocyte gene, RARRES1. Chen A, et al. Kidney Int, 2021 Oct. PMID 34556297, Free PMC Article
  2. Tumor suppressor RARRES1- A novel regulator of fatty acid metabolism in epithelial cells. Maimouni S, et al. PLoS One, 2018. PMID 30557378, Free PMC Article
  3. Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma. Huebner H, et al. J Exp Clin Cancer Res, 2017 Nov 23. PMID 29169400, Free PMC Article
  4. Multiple roles of RARRES1 in prostate cancer: Autophagy induction and angiogenesis inhibition. Roy A, et al. PLoS One, 2017. PMID 28678839, Free PMC Article
  5. TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase. Wang X, et al. Cancer Res, 2013 Nov 1. PMID 24014597, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.
    Title: GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.
  2. TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein.
    Title: TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein.
  3. Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma.
    Title: Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma.
  4. Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets.
    Title: Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets.
  5. Tazarotene-induced gene 1 interacts with Polo-like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells.
    Title: Tazarotene-induced gene 1 interacts with Polo-like kinase 2 and inhibits cell proliferation in HCT116 colorectal cancer cells.
  6. Autocrine and paracrine effects of a novel podocyte gene, RARRES1.
    Title: Autocrine and paracrine effects of a novel podocyte gene, RARRES1.
  7. Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
    Title: Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells.
  8. Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.
    Title: Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.
  9. Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
    Title: Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
  10. Investigated whether tazarotene-induced gene 1 protein (TIG1) affects the activity of urokinase plasminogen-type activator, which is negatively regulated by serine peptidase inhibitor Kazal type 2 (SPINK2), potentially preventing epithelial mesenchymal transition and suppressing cell migration and invasion.
    Title: Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retinoic acid receptor responder protein 1
Names
RAR-responsive protein TIG1
latexin-like
phorbol ester-induced gene 1 protein
retinoic acid receptor responder (tazarotene induced) 1
tazarotene-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002888.4 → NP_002879.2  retinoic acid receptor responder protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_002879.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' end-region compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC080013, BC029640, BM919188
    Consensus CDS
    CCDS54665.1
    UniProtKB/Swiss-Prot
    P49788
    Related
    ENSP00000418556.1, ENST00000479756.1
    Conserved Domains (1) summary
    pfam06907
    Location:52 → 227
    Latexin; Latexin

  2. NM_206963.2 → NP_996846.1  retinoic acid receptor responder protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_996846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer isoform (1).
    Source sequence(s)
    AC080013, AK130079, BC029640, BM919188
    Consensus CDS
    CCDS3184.1
    UniProtKB/Swiss-Prot
    P49788, Q8N1D7
    Related
    ENSP00000237696.5, ENST00000237696.10
    Conserved Domains (1) summary
    pfam06907
    Location:52 → 274
    Latexin; Latexin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    158696892..158732457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247686.6 → XP_005247743.4  retinoic acid receptor responder protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    161470815..161506388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347419.1 → XP_054203394.1  retinoic acid receptor responder protein 1 isoform X1

RNA

  1. XR_008486768.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49788.2 GenPept UniProtKB/Swiss-Prot:P49788

Gene LinkOut

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