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RAP1GAP RAP1 GTPase activating protein [ Homo sapiens (human) ]

Gene ID: 5909, updated on 7-Apr-2024

Summary

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Official Symbol
RAP1GAPprovided by HGNC
Official Full Name
RAP1 GTPase activating proteinprovided by HGNC
Primary source
HGNC:HGNC:9858
See related
Ensembl:ENSG00000076864 MIM:600278; AllianceGenome:HGNC:9858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
Summary
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Expression
Biased expression in thyroid (RPKM 75.3), brain (RPKM 38.1) and 11 other tissues See more
Orthologs
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Genomic context

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Location:
1p36.12
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (21596221..21669357, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (21420130..21493311, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21922714..21995850, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21835859-21836429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21836430-21836999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 334 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:21860784-21861513 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21863949-21864466 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21864467-21864985 Neighboring gene alkaline phosphatase, biomineralization associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21895010-21895594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21900641-21901315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21901316-21901990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21904065-21904588 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21917321-21917860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21917861-21918399 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21928741-21928970 Neighboring gene long intergenic non-protein coding RNA 2596 Neighboring gene Sharpr-MPRA regulatory region 12165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21937517-21938264 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:21939576-21939868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21945135-21945976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21958265-21959233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21961087-21961835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21960338-21961086 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:21966135-21966964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21977615-21978365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:21992551-21993051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 387 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:21996570-21997769 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene uncharacterized LOC124904736 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 336 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:22099067-22099566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 337 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:22108688-22109459 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:22109460-22110230 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:22112153-22112327 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:22137244-22137394 Neighboring gene Sharpr-MPRA regulatory region 6146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:22148116-22148982 Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene heparan sulfate proteoglycan 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer. Faam B, et al. Arch Iran Med, 2022 Mar 1. PMID 35429959
  2. RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer. Faam B, et al. Cytogenet Genome Res, 2021. PMID 34311462
  3. Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation. Shah S, et al. Neoplasia, 2018 Sep. PMID 30144784, Free PMC Article
  4. Reduced expression of Rap1GAP as a prognostic biomarker for primary gastric cancer patients. Zhao J, et al. Cancer Biomark, 2018. PMID 29758923
  5. Rap1GAP inhibits tumor progression in endometrial cancer. Tamate M, et al. Biochem Biophys Res Commun, 2017 Apr 1. PMID 28196746

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
    Title: Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
  2. CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer.
    Title: CpG Island Methylation of the Rap1Gap Gene in Medullary Thyroid Cancer.
  3. Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
    Title: Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation.
  4. Downregulation of Rap1GAP Expression Activates the TGF-beta/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells.
    Title: Downregulation of Rap1GAP Expression Activates the TGF-β/Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells.
  5. RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer.
    Title: RAP1GAP Functions as a Tumor Suppressor Gene and Is Regulated by DNA Methylation in Differentiated Thyroid Cancer.
  6. Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
    Title: Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms.
  7. This is the first mechanistic study of Rap1Gap in breast cancer progression. Decreases in Rap1Gap expression led to changes in adherens junctions via reduction in E-cadherin levels, to cytoskeletal remodeling, and to increases in ERK activation that are correlated with an invasive phenotype in DCIS
    Title: Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation.
  8. Rap1GAP may play a significant role in gastric cancer progression and act as a valuable prognostic marker for gastric cancer.
    Title: Reduced expression of Rap1GAP as a prognostic biomarker for primary gastric cancer patients.
  9. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
    Title: Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.
  10. Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC).
    Title: Rap1GAP inhibits tumor progression in endometrial cancer.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0474

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity EXP
Inferred from Experiment
more info
 PubMed 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response TAS
Traceable Author Statement
more info
  
involved_in cellular response to glial cell derived neurotrophic factor IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of microvillus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of thyroid gland epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rap1 GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029807.1 RefSeqGene

    Range
    5007..78143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145657.3 → NP_001139129.1  rap1 GTPase-activating protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001139129.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice junctions compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform 4. Isoform 2 is also known as isoform b.
    Source sequence(s)
    AB007943, BC035030, HY115754
    Consensus CDS
    CCDS53276.1
    UniProtKB/TrEMBL
    J3KPC5
    Related
    ENSP00000441661.1, ENST00000542643.6
    Conserved Domains (2) summary
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:1 → 17
    GoLoco; GoLoco motif

  2. NM_001145658.3 → NP_001139130.1  rap1 GTPase-activating protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001139130.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (1) is longer at the N-terminus and lacks an alternate internal segment compared to isoform 4. Isoform 1 is also known as isoform a.
    Source sequence(s)
    AL359815, BC035030, BC054490, BM739021, BP200029, CV574545
    Consensus CDS
    CCDS53277.1
    UniProtKB/TrEMBL
    J3KPC5
    Related
    ENSP00000434033.2, ENST00000495204.5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  3. NM_001330383.3 → NP_001317312.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4). Isoform 4 is also known as isoform d.
    Source sequence(s)
    AB007943, BC035030, BI546732, BM742308, HY115754
    Consensus CDS
    CCDS81276.1
    UniProtKB/TrEMBL
    J3KPC5, X6R8W7
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  4. NM_001350524.2 → NP_001337453.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: Isoform 5 is also known as isoform e.
    Source sequence(s)
    AB007943, AI301600, BC035030, BI546732, HY115754
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  5. NM_001350525.2 → NP_001337454.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: Isoform 6 is also known as isoform f.
    Source sequence(s)
    AB007943, AI301600, BC035030, BX094488, HY115754
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  6. NM_001350526.2 → NP_001337455.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AB007943, AF114047, AI301600, AL359815, BC035030, BX094488, HY115754
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  7. NM_001350527.2 → NP_001337456.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB007943, AI301600, BC035030, BM821324, BX094488, HY115754, HY136222
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  8. NM_001350528.2 → NP_001337457.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: Isoform 7 is also known as isoform g.
    Source sequence(s)
    AB007943, AI301600, BC035030, BM821324, BX094488, CF139631, HY115754, HY136222
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  9. NM_001388200.1 → NP_001375129.1  rap1 GTPase-activating protein 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  10. NM_001388201.1 → NP_001375130.1  rap1 GTPase-activating protein 1 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  11. NM_001388202.1 → NP_001375131.1  rap1 GTPase-activating protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  12. NM_001388203.1 → NP_001375132.1  rap1 GTPase-activating protein 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  13. NM_001388204.1 → NP_001375133.1  rap1 GTPase-activating protein 1 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  14. NM_001388205.1 → NP_001375134.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS81276.1
    UniProtKB/TrEMBL
    J3KPC5, X6R8W7
    Related
    ENSP00000363895.2, ENST00000374763.6
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  15. NM_001388206.1 → NP_001375135.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS81276.1
    UniProtKB/TrEMBL
    J3KPC5, X6R8W7
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  16. NM_001388207.1 → NP_001375136.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS81276.1
    UniProtKB/TrEMBL
    J3KPC5, X6R8W7
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  17. NM_001388208.1 → NP_001375137.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS81276.1
    UniProtKB/TrEMBL
    J3KPC5, X6R8W7
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  18. NM_001388209.1 → NP_001375138.1  rap1 GTPase-activating protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS81276.1
    UniProtKB/TrEMBL
    J3KPC5, X6R8W7
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  19. NM_001388210.1 → NP_001375139.1  rap1 GTPase-activating protein 1 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  20. NM_001388211.1 → NP_001375140.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  21. NM_001388212.1 → NP_001375141.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  22. NM_001388213.1 → NP_001375142.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  23. NM_001388214.1 → NP_001375143.1  rap1 GTPase-activating protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  24. NM_001388215.1 → NP_001375144.1  rap1 GTPase-activating protein 1 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 366
    Rap_GAP; Rap/ran-GAP

  25. NM_001388216.1 → NP_001375145.1  rap1 GTPase-activating protein 1 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  26. NM_001388217.1 → NP_001375146.1  rap1 GTPase-activating protein 1 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    Q49AP2
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  27. NM_001388218.1 → NP_001375147.1  rap1 GTPase-activating protein 1 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (3) summary
    PTZ00449
    Location:456 → 603
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  28. NM_001388219.1 → NP_001375148.1  rap1 GTPase-activating protein 1 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:183 → 362
    Rap_GAP; Rap/ran-GAP

  29. NM_001388220.1 → NP_001375149.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  30. NM_001388221.1 → NP_001375150.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  31. NM_001388222.1 → NP_001375151.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  32. NM_001388223.1 → NP_001375152.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  33. NM_001388224.1 → NP_001375153.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  34. NM_001388225.1 → NP_001375154.1  rap1 GTPase-activating protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  35. NM_001388226.1 → NP_001375155.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS53276.1
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:1 → 17
    GoLoco; GoLoco motif

  36. NM_001388227.1 → NP_001375156.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS53276.1
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:1 → 17
    GoLoco; GoLoco motif

  37. NM_001388228.1 → NP_001375157.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS53276.1
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:1 → 17
    GoLoco; GoLoco motif

  38. NM_001388229.1 → NP_001375158.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS53276.1
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:1 → 17
    GoLoco; GoLoco motif

  39. NM_001388230.1 → NP_001375159.1  rap1 GTPase-activating protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS53276.1
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP
    pfam02188
    Location:1 → 17
    GoLoco; GoLoco motif

  40. NM_001388231.1 → NP_001375160.1  rap1 GTPase-activating protein 1 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (1) summary
    pfam02145
    Location:202 → 381
    Rap_GAP; Rap/ran-GAP

  41. NM_001388233.1 → NP_001375162.1  rap1 GTPase-activating protein 1 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:198 → 377
    Rap_GAP; Rap/ran-GAP

  42. NM_001388234.1 → NP_001375163.1  rap1 GTPase-activating protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 373
    Rap_GAP; Rap/ran-GAP

  43. NM_001388235.1 → NP_001375164.1  rap1 GTPase-activating protein 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 373
    Rap_GAP; Rap/ran-GAP

  44. NM_001388236.1 → NP_001375165.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  45. NM_001388237.1 → NP_001375166.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  46. NM_001388238.1 → NP_001375167.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  47. NM_001388239.1 → NP_001375168.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  48. NM_001388240.1 → NP_001375169.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  49. NM_001388241.1 → NP_001375170.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Related
    ENSP00000363893.2, ENST00000374761.6
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  50. NM_001388242.1 → NP_001375171.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  51. NM_001388243.1 → NP_001375172.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  52. NM_001388244.1 → NP_001375173.1  rap1 GTPase-activating protein 1 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:183 → 362
    Rap_GAP; Rap/ran-GAP

  53. NM_001388245.1 → NP_001375174.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  54. NM_001388246.1 → NP_001375175.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  55. NM_001388247.1 → NP_001375176.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  56. NM_001388248.1 → NP_001375177.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  57. NM_001388249.1 → NP_001375178.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  58. NM_001388250.1 → NP_001375179.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  59. NM_001388251.1 → NP_001375180.1  rap1 GTPase-activating protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  60. NM_001388252.1 → NP_001375181.1  rap1 GTPase-activating protein 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  61. NM_001388253.1 → NP_001375182.1  rap1 GTPase-activating protein 1 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 373
    Rap_GAP; Rap/ran-GAP

  62. NM_001388254.1 → NP_001375183.1  rap1 GTPase-activating protein 1 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  63. NM_001388255.1 → NP_001375184.1  rap1 GTPase-activating protein 1 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  64. NM_001388256.1 → NP_001375185.1  rap1 GTPase-activating protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 366
    Rap_GAP; Rap/ran-GAP

  65. NM_001388258.1 → NP_001375187.1  rap1 GTPase-activating protein 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 366
    Rap_GAP; Rap/ran-GAP

  66. NM_001388259.1 → NP_001375188.1  rap1 GTPase-activating protein 1 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 373
    Rap_GAP; Rap/ran-GAP

  67. NM_001388261.1 → NP_001375190.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  68. NM_001388263.1 → NP_001375192.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  69. NM_001388264.1 → NP_001375193.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  70. NM_001388266.1 → NP_001375195.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  71. NM_001388267.1 → NP_001375196.1  rap1 GTPase-activating protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  72. NM_001388269.1 → NP_001375198.1  rap1 GTPase-activating protein 1 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (1) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

  73. NM_001388270.1 → NP_001375199.1  rap1 GTPase-activating protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  74. NM_001388273.1 → NP_001375202.1  rap1 GTPase-activating protein 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  75. NM_001388276.1 → NP_001375205.1  rap1 GTPase-activating protein 1 isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56 → 235
    Rap_GAP; Rap/ran-GAP

  76. NM_001388279.1 → NP_001375208.1  rap1 GTPase-activating protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56 → 235
    Rap_GAP; Rap/ran-GAP

  77. NM_001388280.1 → NP_001375209.1  rap1 GTPase-activating protein 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56 → 235
    Rap_GAP; Rap/ran-GAP

  78. NM_001388281.1 → NP_001375210.1  rap1 GTPase-activating protein 1 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Conserved Domains (1) summary
    pfam02145
    Location:56 → 235
    Rap_GAP; Rap/ran-GAP

  79. NM_001388282.1 → NP_001375211.1  rap1 GTPase-activating protein 1 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (1) summary
    pfam02145
    Location:172 → 351
    Rap_GAP; Rap/ran-GAP

  80. NM_001388283.1 → NP_001375212.1  rap1 GTPase-activating protein 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Related
    ENSP00000431364.1, ENST00000471600.6
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  81. NM_001388284.1 → NP_001375213.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  82. NM_001388285.1 → NP_001375214.1  rap1 GTPase-activating protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

  83. NM_001388286.1 → NP_001375215.1  rap1 GTPase-activating protein 1 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 437
    Rap_GAP; Rap/ran-GAP

  84. NM_001388287.1 → NP_001375216.1  rap1 GTPase-activating protein 1 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  85. NM_001388288.1 → NP_001375217.1  rap1 GTPase-activating protein 1 isoform 37

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  86. NM_001388289.1 → NP_001375218.1  rap1 GTPase-activating protein 1 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  87. NM_001388290.1 → NP_001375219.1  rap1 GTPase-activating protein 1 isoform 39

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 452
    Rap_GAP; Rap/ran-GAP

  88. NM_001388291.1 → NP_001375220.1  rap1 GTPase-activating protein 1 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 430
    Rap_GAP; Rap/ran-GAP

  89. NM_001388292.1 → NP_001375221.1  rap1 GTPase-activating protein 1 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  90. NM_001388293.1 → NP_001375222.1  rap1 GTPase-activating protein 1 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  91. NM_001388294.1 → NP_001375223.1  rap1 GTPase-activating protein 1 isoform 43

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  92. NM_001388295.1 → NP_001375224.1  rap1 GTPase-activating protein 1 isoform 44

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  93. NM_001388296.1 → NP_001375225.1  rap1 GTPase-activating protein 1 isoform 45

    Status: REVIEWED

    Source sequence(s)
    AL359815
    UniProtKB/TrEMBL
    J3KPC5
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  94. NM_002885.4 → NP_002876.2  rap1 GTPase-activating protein 1 isoform 3

    See identical proteins and their annotated locations for NP_002876.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4. Variants 3 and 8 encode the same protein (isoform 3). Isoform 3 is also known as isoform c.
    Source sequence(s)
    AB007943, AL359815, BC035030, HY115754, M64788
    Consensus CDS
    CCDS218.1
    UniProtKB/Swiss-Prot
    J3QSS6, O75062, P47736, Q5T3S9, Q5T3T4, Q7Z5S8, Q9UQ51
    UniProtKB/TrEMBL
    J3KPC5
    Related
    ENSP00000363897.4, ENST00000374765.9
    Conserved Domains (2) summary
    smart00390
    Location:1 → 17
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:211 → 390
    Rap_GAP; Rap/ran-GAP

RNA

  1. NR_170899.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  2. NR_170900.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  3. NR_170901.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  4. NR_170902.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815
    Related
    ENST00000611549.4

  5. NR_170903.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  6. NR_170904.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  7. NR_170905.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  8. NR_170906.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  9. NR_170907.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  10. NR_170908.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  11. NR_170909.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  12. NR_170910.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  13. NR_170911.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  14. NR_170912.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  15. NR_170913.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  16. NR_170914.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  17. NR_170915.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  18. NR_170916.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  19. NR_170920.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  20. NR_170921.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  21. NR_170923.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  22. NR_170924.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  23. NR_170925.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  24. NR_170926.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  25. NR_170927.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  26. NR_170928.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

  27. NR_170929.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL359815

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    21596221..21669357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    21420130..21493311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47736.2 GenPept UniProtKB/Swiss-Prot:P47736

Gene LinkOut

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