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Pxmp4 peroxisomal membrane protein 4 [ Mus musculus (house mouse) ]

Gene ID: 59038, updated on 2-Nov-2024

Summary

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Official Symbol
Pxmp4provided by MGI
Official Full Name
peroxisomal membrane protein 4provided by MGI
Primary source
MGI:MGI:1891701
See related
Ensembl:ENSMUSG00000000876 AllianceGenome:MGI:1891701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pmp24; 3010018P03Rik
Summary
Acts upstream of or within ether lipid metabolic process. Predicted to be located in peroxisome. Predicted to be active in peroxisomal membrane. Orthologous to human PXMP4 (peroxisomal membrane protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in liver adult (RPKM 36.1), kidney adult (RPKM 34.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Pxmp4 in Genome Data Viewer
Location:
2 H1; 2 76.79 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154427678..154445592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154585758..154603730, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene N-terminal EF-hand calcium binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E816 Neighboring gene E2F transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_06129 Neighboring gene predicted gene, 39963 Neighboring gene STARR-seq mESC enhancer starr_06130 Neighboring gene STARR-positive B cell enhancer ABC_E228 Neighboring gene zinc finger protein 341 Neighboring gene predicted gene 14198 Neighboring gene STARR-positive B cell enhancer ABC_E7873 Neighboring gene STARR-positive B cell enhancer ABC_E6003 Neighboring gene charged multivesicular body protein 4B Neighboring gene RIKEN cDNA 9030607L20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism. Blankestijn M, et al. Sci Rep, 2022 Feb 15. PMID 35169201, Free PMC Article
  2. Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4. Fletcher JM, et al. J Immunol, 2008 Sep 1. PMID 18714012
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
    Title: Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
  2. genetic sequences on chromosome 2 that control NKT cell numbers
    Title: Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within ether lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal membrane protein 4
Names
24 kDa intrinsic membrane protein
24 kDa peroxisomal intrinsic membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418211.1 → NP_001405140.1  peroxisomal membrane protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL772292, AL929557

  2. NM_001418212.1 → NP_001405141.1  peroxisomal membrane protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL772292, AL929557

  3. NM_001418214.1 → NP_001405143.1  peroxisomal membrane protein 4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL772292, AL929557

  4. NM_001418216.1 → NP_001405145.1  peroxisomal membrane protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL772292, AL929557
    UniProtKB/TrEMBL
    A2AKD6
    Related
    ENSMUSP00000105325.3, ENSMUST00000109703.3

  5. NM_001418221.1 → NP_001405150.1  peroxisomal membrane protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL772292, AL929557

  6. NM_021534.4 → NP_067509.1  peroxisomal membrane protein 4 isoform 1

    See identical proteins and their annotated locations for NP_067509.1

    Status: VALIDATED

    Source sequence(s)
    AL772292, AL929557
    Consensus CDS
    CCDS16936.1
    UniProtKB/Swiss-Prot
    Q3U0L9, Q9CQV9, Q9JJW0
    Related
    ENSMUSP00000000896.5, ENSMUST00000000896.11
    Conserved Domains (1) summary
    pfam02466
    Location:23 → 138
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    154427678..154445592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJW0.3 GenPept UniProtKB/Swiss-Prot:Q9JJW0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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