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Sqor sulfide quinone oxidoreductase [ Mus musculus (house mouse) ]

Gene ID: 59010, updated on 3-Nov-2024

Summary

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Official Symbol
Sqorprovided by MGI
Official Full Name
sulfide quinone oxidoreductaseprovided by MGI
Primary source
MGI:MGI:1929899
See related
Ensembl:ENSMUSG00000005803 AllianceGenome:MGI:1929899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sqrdl; 0610039J17Rik; 4930557M22Rik
Summary
Predicted to enable FAD binding activity; glutathione-dependent sulfide quinone oxidoreductase activity; and sulfide:quinone oxidoreductase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Located in mitochondrial inner membrane. Orthologous to human SQOR (sulfide quinone oxidoreductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 67.7), colon adult (RPKM 56.3) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Sqor in Genome Data Viewer
Location:
2 E5; 2 60.67 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122607249..122651473)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122765327..122809553)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05562 Neighboring gene STARR-positive B cell enhancer ABC_E10136 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 6, pallidin Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:122615227-122615418 Neighboring gene STARR-seq mESC enhancer starr_05563 Neighboring gene predicted gene, 34430 Neighboring gene STARR-seq mESC enhancer starr_05564 Neighboring gene predicted gene, 54147

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sulfide catabolism ameliorates hypoxic brain injury. Marutani E, et al. Nat Commun, 2021 May 25. PMID 34035265, Free PMC Article
  2. Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS. Linden DR, et al. Br J Pharmacol, 2012 Apr. PMID 21950400, Free PMC Article
  3. SQR mediates therapeutic effects of H(2)S by targeting mitochondrial electron transport to induce mitochondrial uncoupling. Jia J, et al. Sci Adv, 2020 Aug. PMID 32923620, Free PMC Article
  4. The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria. Ackermann M, et al. Cell Tissue Res, 2014 Dec. PMID 25130143
  5. Sulfide quinone oxidoreductase contributes to voltage sensing of the mitochondrial permeability transition pore. Griffiths KK, et al. FASEB J, 2024 Feb 29. PMID 38376922,

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulfide quinone oxidoreductase contributes to voltage sensing of the mitochondrial permeability transition pore.
    Title: Sulfide quinone oxidoreductase contributes to voltage sensing of the mitochondrial permeability transition pore.
  2. Sulfide catabolism ameliorates hypoxic brain injury.
    Title: Sulfide catabolism ameliorates hypoxic brain injury.
  3. The present report demonstrates the presence and specific localization of SQRDL in various mammalian tissues.
    Title: The vertebrate homologue of sulfide-quinone reductase in mammalian mitochondria.
  4. Levels of mRNA encoding SQR were higher in the colonic muscularis externa and the liver than in the brain.
    Title: Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione-dependent sulfide quinone oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione-dependent sulfide quinone oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
enables sulfide:quinone oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfide:quinone oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfide:quinone oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in sulfide oxidation, using sulfide:quinone oxidoreductase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sulfide oxidation, using sulfide:quinone oxidoreductase ISO
Inferred from Sequence Orthology
more info
  
involved_in sulfide oxidation, using sulfide:quinone oxidoreductase ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sulfide:quinone oxidoreductase, mitochondrial
Names
flavo-binding protein
sulfide quinone reductase-like
NP_001155975.1
NP_067482.4
XP_006500029.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162503.1 → NP_001155975.1  sulfide:quinone oxidoreductase, mitochondrial

    See identical proteins and their annotated locations for NP_001155975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075598, BP772838
    Consensus CDS
    CCDS16669.1
    UniProtKB/Swiss-Prot
    Q8BW20, Q91XA1, Q9D891, Q9R112
    UniProtKB/TrEMBL
    Q3UDS4
    Related
    ENSMUSP00000005953.5, ENSMUST00000005953.11
    Conserved Domains (1) summary
    COG0446
    Location:46 → 397
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

  2. NM_021507.5 → NP_067482.4  sulfide:quinone oxidoreductase, mitochondrial

    See identical proteins and their annotated locations for NP_067482.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075598, AL928950, BP772838
    Consensus CDS
    CCDS16669.1
    UniProtKB/Swiss-Prot
    Q8BW20, Q91XA1, Q9D891, Q9R112
    UniProtKB/TrEMBL
    Q3UDS4
    Related
    ENSMUSP00000106133.3, ENSMUST00000110506.9
    Conserved Domains (1) summary
    COG0446
    Location:46 → 397
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]

RNA

  1. NR_027888.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK075598, AL928950, BP772838

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122607249..122651473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499966.3 → XP_006500029.1  sulfide:quinone oxidoreductase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006500029.1

    UniProtKB/Swiss-Prot
    Q8BW20, Q91XA1, Q9D891, Q9R112
    UniProtKB/TrEMBL
    Q3UDS4
    Conserved Domains (1) summary
    COG0446
    Location:46 → 397
    FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R112.3 GenPept UniProtKB/Swiss-Prot:Q9R112

Gene LinkOut

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