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Arhgap23 Rho GTPase activating protein 23 [ Mus musculus (house mouse) ]

Gene ID: 58996, updated on 2-Nov-2024

Summary

Official Symbol
Arhgap23provided by MGI
Official Full Name
Rho GTPase activating protein 23provided by MGI
Primary source
MGI:MGI:3697726
See related
Ensembl:ENSMUSG00000049807 AllianceGenome:MGI:3697726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A330041B18Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in several structures, including aorta; brain; endocrine gland; female reproductive system; and retina. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 28.9), lung adult (RPKM 24.8) and 28 other tissues See more
Orthologs
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Genomic context

See Arhgap23 in Genome Data Viewer
Location:
11 D; 11 60.97 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97295183..97393228)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97404357..97502402)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53647 Neighboring gene G protein-coupled receptor 179 Neighboring gene suppressor of cytokine signaling 7 Neighboring gene STARR-seq mESC enhancer starr_30603 Neighboring gene STARR-positive B cell enhancer ABC_E10709 Neighboring gene STARR-seq mESC enhancer starr_30610 Neighboring gene RIKEN cDNA 4933428G20 gene Neighboring gene STARR-positive B cell enhancer ABC_E11489 Neighboring gene STARR-positive B cell enhancer ABC_E11490 Neighboring gene STARR-positive B cell enhancer mm9_chr11:97394449-97394749 Neighboring gene SRC kinase signaling inhibitor 1 Neighboring gene STARR-seq mESC enhancer starr_30619 Neighboring gene RIKEN cDNA 2410003L11 gene Neighboring gene STARR-seq mESC enhancer starr_30621 Neighboring gene predicted gene, 38962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
rho GTPase-activating protein 23
Names
rho-type GTPase-activating protein 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428751.1NP_001415680.1  rho GTPase-activating protein 23 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596088
    UniProtKB/TrEMBL
    B1AQY2
  2. NM_021493.3NP_067468.2  rho GTPase-activating protein 23 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596088
    Consensus CDS
    CCDS36293.1
    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    UniProtKB/TrEMBL
    F8VQ11
    Related
    ENSMUSP00000103227.2, ENSMUST00000107601.8
    Conserved Domains (3) summary
    cd04395
    Location:692887
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:480600
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:479598
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97295183..97393228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533867.3XP_006533930.1  rho GTPase-activating protein 23 isoform X6

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:158560
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:23138
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:8851080
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:673793
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  2. XM_030246200.1XP_030102060.1  rho GTPase-activating protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  3. XM_036156873.1XP_036012766.1  rho GTPase-activating protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  4. XM_006533865.4XP_006533928.1  rho GTPase-activating protein 23 isoform X4

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:176578
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:41156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9031098
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:691811
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  5. XM_006533866.4XP_006533929.1  rho GTPase-activating protein 23 isoform X5

    Related
    ENSMUSP00000112999.2, ENSMUST00000121799.8
    Conserved Domains (4) summary
    PHA03247
    Location:176578
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:41156
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:9031098
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:691811
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  6. XM_006533869.4XP_006533932.2  rho GTPase-activating protein 23 isoform X8

    Conserved Domains (4) summary
    PHA03247
    Location:77479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  7. XM_006533868.5XP_006533931.2  rho GTPase-activating protein 23 isoform X8

    Conserved Domains (4) summary
    PHA03247
    Location:77479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  8. XM_006533861.5XP_006533924.2  rho GTPase-activating protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  9. XM_006533862.5XP_006533925.2  rho GTPase-activating protein 23 isoform X2

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:804999
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:592712
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  10. XM_006533863.5XP_006533926.2  rho GTPase-activating protein 23 isoform X3

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (4) summary
    PHA03247
    Location:77479
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:457
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:721916
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cl17171
    Location:496629
    PH-like; Pleckstrin homology-like domain
  11. XM_030246201.2XP_030102061.1  rho GTPase-activating protein 23 isoform X7

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (3) summary
    PHA03247
    Location:20422
    PHA03247; large tegument protein UL36; Provisional
    cd04395
    Location:747942
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:535655
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  12. XM_006533871.5XP_006533934.1  rho GTPase-activating protein 23 isoform X9

    UniProtKB/Swiss-Prot
    Q69ZH9, Q8BNY7, Q9JJD6
    Conserved Domains (3) summary
    PHA03307
    Location:3281
    PHA03307; transcriptional regulator ICP4; Provisional
    cd04395
    Location:692887
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:480600
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  13. XM_006533874.4XP_006533937.1  rho GTPase-activating protein 23 isoform X10

    Conserved Domains (2) summary
    cd04395
    Location:107302
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cl17171
    Location:115
    PH-like; Pleckstrin homology-like domain
  14. XM_036156874.1XP_036012767.1  rho GTPase-activating protein 23 isoform X11

    Conserved Domains (2) summary
    cd04395
    Location:107302
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cl17171
    Location:115
    PH-like; Pleckstrin homology-like domain