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Fut2 fucosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58924, updated on 2-Nov-2024

Summary

Official Symbol
Fut2provided by RGD
Official Full Name
fucosyltransferase 2provided by RGD
Primary source
RGD:2639
See related
EnsemblRapid:ENSRNOG00000021011 AllianceGenome:RGD:2639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ftc; Futb
Summary
Enables galactoside 2-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Human ortholog(s) of this gene implicated in vitamin B12 deficiency. Orthologous to human FUT2 (fucosyltransferase 2 (H blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 11.6), Thymus (RPKM 10.2) and 8 other tissues See more
Orthologs
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Genomic context

See Fut2 in Genome Data Viewer
Location:
1q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105256013..105276828, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96119549..96139567, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101631633..101651668, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Ras interacting protein 1 Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fucosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fucosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in fucosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galactoside alpha-(1,2)-fucosyltransferase 2
Names
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
alpha 1,2-fucosyltransferase B
alpha 1-2 fucosyltransferase
alpha 12-fucosyltransferase C
alpha(1,2)FT 2
alpha1,2-fucosyltransferase b
fucosyltransferase 2 (secretor status included)
galactoside 2-alpha-L-fucosyltransferase 2
secretor blood group alpha-2-fucosyltransferase
type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
NP_113823.1
XP_038944697.1
XP_063128208.1
XP_063128215.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031635.1NP_113823.1  galactoside alpha-(1,2)-fucosyltransferase 2

    See identical proteins and their annotated locations for NP_113823.1

    Status: PROVISIONAL

    Source sequence(s)
    AB006138
    UniProtKB/Swiss-Prot
    O35087, Q10984, Q9JK44, Q9R275
    UniProtKB/TrEMBL
    A0A0G2JSS7, A6JB65
    Related
    ENSRNOP00000028519.1, ENSRNOT00000028519.4
    Conserved Domains (1) summary
    pfam01531
    Location:52344
    Glyco_transf_11; Glycosyl transferase family 11

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105256013..105276828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272138.1XP_063128208.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSS7, A6JB65
    Related
    ENSRNOP00000093031.1, ENSRNOT00000097049.2
  2. XM_039088769.2XP_038944697.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    O35087, Q10984, Q9JK44, Q9R275
    UniProtKB/TrEMBL
    A0A0G2JSS7, A6JB65
    Related
    ENSRNOP00000081835.1, ENSRNOT00000099964.2
    Conserved Domains (1) summary
    pfam01531
    Location:52344
    Glyco_transf_11; Glycosyl transferase family 11
  3. XM_063272145.1XP_063128215.1  galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSS7, A6JB65
    Related
    ENSRNOP00000091583.1, ENSRNOT00000101535.2