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MOK MOK protein kinase [ Homo sapiens (human) ]

Gene ID: 5891, updated on 5-Mar-2024

Summary

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Official Symbol
MOKprovided by HGNC
Official Full Name
MOK protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:9833
See related
Ensembl:ENSG00000080823 MIM:605762; AllianceGenome:HGNC:9833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGE; RAGE1; STK30; RAGE-1
Summary
This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Expression
Broad expression in testis (RPKM 9.4), thyroid (RPKM 2.1) and 15 other tissues See more
Orthologs
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Genomic context

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See MOK in Genome Data Viewer
Location:
14q32.31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102214596..102305164, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96451049..96540765, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102690778..102771501, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102550057-102551256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6109 Neighboring gene heat shock protein 90 alpha family class A member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6110 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102605474-102605669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102622168-102623084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102623085-102624001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102625184-102625684 Neighboring gene WD repeat domain 20 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:102638165-102639150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102650679-102651180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102651181-102651680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6111 Neighboring gene uncharacterized LOC105370677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102780520-102781020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9070 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene zinc finger protein 839

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MOK overexpression is associated with promoter hypomethylation in patients with acute myeloid leukemia. Qian J, et al. Int J Clin Exp Pathol, 2015. PMID 25755699, Free PMC Article
  2. Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma. Cha HJ, et al. Ann Surg Oncol, 2012 Jul. PMID 21717246
  3. Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas. Yan M, et al. Appl Immunohistochem Mol Morphol, 2003 Jun. PMID 12777992
  4. Tumor-associated antigens as possible targets for immune therapy in head and neck cancer: comparative mRNA expression analysis of RAGE and GAGE genes. Götte K, et al. Acta Otolaryngol, 2002 Jul. PMID 12206267
  5. mRNA expression of tumor-associated antigens in melanoma tissues and cell lines. Eichmüller S, et al. Exp Dermatol, 2002 Aug. PMID 12190937

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAGE silencing deters CML-AGE induced inflammation and TLR4 expression in endothelial cells.
    Title: RAGE silencing deters CML-AGE induced inflammation and TLR4 expression in endothelial cells.
  2. our results suggest MOK promoter hypomethylation is a common event and contributes to MOK overexpression in acute myeloid leukemia
    Title: MOK overexpression is associated with promoter hypomethylation in patients with acute myeloid leukemia.
  3. The findings indicate a statistically significant association of p.Gly82Ser polymorphism in RAGE with DR in T2DM patients.
    Title: Association of RAGE (p.Gly82Ser) and MnSOD (p.Val16Ala) polymorphisms with diabetic retinopathy in T2DM patients from north India.
  4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
    Title: Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity.
  5. Our results suggest that RAGE may be important in tumor invasion and could be a potential predictor for the prognosis of hepatocellular carcinoma patients.
    Title: Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma.
  6. PBMNC from type 2 diabetics were more sensitive to innate immune stimulation with LPS and monoclonal agonist anti-TLR4 than were cells from ND. The actions of LPS, anti-TLR4 and anti-RAGE potentiated the production of IL-6 and TNF-alpha in both groups.
    Title: TLR4 and RAGE: similar routes leading to inflammation in type 2 diabetic patients.
  7. The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B.
    Title: S100B attenuates microglia activation in gliomas: possible role of STAT3 pathway.
  8. POLL is under genetic selection in Sub-Saharan African populations.
    Title: Targeted resequencing of two genes, RAGE and POLL, confirms findings from a genome-wide scan for adaptive evolution and provides evidence for positive selection in additional populations.
  9. Compared RAGE and PAX-2 staining in metastatic clear renal cell carcinoma.
    Title: The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma marker.
  10. RAGE was demonstrated in all 8 yolk sac tumors and 21 of 26 embryonal carcinomas. In yolk sac tumors, RAGE reactivity was diffusely present throughout the tumors. In embryonal carcinomas, RAGE was identified only in yolk sac components
    Title: Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16778

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary base ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MAPK/MAK/MRK overlapping kinase
Names
renal cell carcinoma antigen
renal tumor antigen 1
NP_001258940.1
NP_001317163.1
NP_001340756.1
NP_001340757.1
NP_001340758.1
NP_001340759.1
NP_001340760.1
NP_001340761.1
NP_055041.1
XP_006720289.1
XP_016877045.1
XP_016877046.1
XP_016877047.1
XP_047287599.1
XP_047287600.1
XP_047287601.1
XP_047287602.1
XP_047287603.1
XP_047287604.1
XP_047287605.1
XP_047287606.1
XP_054232495.1
XP_054232496.1
XP_054232497.1
XP_054232498.1
XP_054232499.1
XP_054232500.1
XP_054232501.1
XP_054232502.1
XP_054232503.1
XP_054232504.1
XP_054232505.1
XP_054232506.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272011.2 → NP_001258940.1  MAPK/MAK/MRK overlapping kinase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB022694, AK302349, AL359402, DB517173
    Consensus CDS
    CCDS61552.1
    UniProtKB/Swiss-Prot
    Q9UQ07
    Related
    ENSP00000428942.1, ENST00000524214.5
    Conserved Domains (2) summary
    smart00220
    Location:4 → 255
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4 → 255
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

  2. NM_001330234.2 → NP_001317163.1  MAPK/MAK/MRK overlapping kinase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402, DB517173
    Consensus CDS
    CCDS81854.1
    UniProtKB/Swiss-Prot
    Q9UQ07
    Related
    ENSP00000429469.1, ENST00000522874.5

  3. NM_001353827.2 → NP_001340756.1  MAPK/MAK/MRK overlapping kinase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cd07831
    Location:4 → 254
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

  4. NM_001353828.2 → NP_001340757.1  MAPK/MAK/MRK overlapping kinase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cl21453
    Location:1 → 221
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001353829.2 → NP_001340758.1  MAPK/MAK/MRK overlapping kinase isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cl21453
    Location:1 → 180
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001353830.2 → NP_001340759.1  MAPK/MAK/MRK overlapping kinase isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (1) summary
    cl21453
    Location:1 → 179
    PKc_like; Protein Kinases, catalytic domain

  7. NM_001353831.2 → NP_001340760.1  MAPK/MAK/MRK overlapping kinase isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    UniProtKB/TrEMBL
    Q49A77
    Conserved Domains (1) summary
    cl21453
    Location:1 → 103
    PKc_like; Protein Kinases, catalytic domain

  8. NM_001353832.2 → NP_001340761.1  MAPK/MAK/MRK overlapping kinase isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402
    Conserved Domains (2) summary
    COG0515
    Location:2 → 135
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cl21453
    Location:1 → 51
    PKc_like; Protein Kinases, catalytic domain

  9. NM_014226.3 → NP_055041.1  MAPK/MAK/MRK overlapping kinase isoform 1

    See identical proteins and their annotated locations for NP_055041.1

    Status: REVIEWED

    Source sequence(s)
    AB022694, DB037795, DB517173
    Consensus CDS
    CCDS9971.1
    UniProtKB/Swiss-Prot
    B2R6Z4, B7Z7P6, E7ER76, E7ERR8, Q92790, Q93067, Q9UQ07
    Related
    ENSP00000355304.2, ENST00000361847.7
    Conserved Domains (2) summary
    smart00220
    Location:4 → 285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4 → 285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

RNA

  1. NR_073540.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL359402, U46193, U46194
    Related
    ENST00000559138.5

  2. NR_073541.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    U46193
    Related
    ENST00000517966.5

  3. NR_073542.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon structure and lacks an internal exon compared to variant 1. This variant is represented as non-coding because the longest open reading frame is in a different frame compared to variant 1, and there is no support for the predicted protein encoded by this ORF.
    Source sequence(s)
    DB517173, U46192, U46193
    Related
    ENST00000524370.5

  4. NR_073543.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BG184866, DB517173, U46191, U46193
    Related
    ENST00000523231.5

  5. NR_148552.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL352978, AL359402

  6. NR_148553.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402

  7. NR_148554.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402

  8. NR_148555.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402

  9. NR_148556.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AI932404, AL352978, AL359402

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    102214596..102305164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431647.1 → XP_047287603.1  MAPK/MAK/MRK overlapping kinase isoform X8

  2. XM_047431646.1 → XP_047287602.1  MAPK/MAK/MRK overlapping kinase isoform X6

  3. XM_017021556.3 → XP_016877045.1  MAPK/MAK/MRK overlapping kinase isoform X4

  4. XM_017021558.2 → XP_016877047.1  MAPK/MAK/MRK overlapping kinase isoform X9

  5. XM_017021557.3 → XP_016877046.1  MAPK/MAK/MRK overlapping kinase isoform X7

  6. XM_047431644.1 → XP_047287600.1  MAPK/MAK/MRK overlapping kinase isoform X3

  7. XM_006720226.4 → XP_006720289.1  MAPK/MAK/MRK overlapping kinase isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:4 → 285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07831
    Location:4 → 285
    STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

  8. XM_047431643.1 → XP_047287599.1  MAPK/MAK/MRK overlapping kinase isoform X1

  9. XM_047431645.1 → XP_047287601.1  MAPK/MAK/MRK overlapping kinase isoform X5

  10. XM_047431650.1 → XP_047287606.1  MAPK/MAK/MRK overlapping kinase isoform X12

  11. XM_047431649.1 → XP_047287605.1  MAPK/MAK/MRK overlapping kinase isoform X11

  12. XM_047431648.1 → XP_047287604.1  MAPK/MAK/MRK overlapping kinase isoform X10

RNA

  1. XR_007064041.1 RNA Sequence

  2. XR_007064040.1 RNA Sequence

  3. XR_007064039.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    96451049..96540765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376527.1 → XP_054232502.1  MAPK/MAK/MRK overlapping kinase isoform X8

  2. XM_054376525.1 → XP_054232500.1  MAPK/MAK/MRK overlapping kinase isoform X6

  3. XM_054376523.1 → XP_054232498.1  MAPK/MAK/MRK overlapping kinase isoform X4

  4. XM_054376524.1 → XP_054232499.1  MAPK/MAK/MRK overlapping kinase isoform X5

  5. XM_054376531.1 → XP_054232506.1  MAPK/MAK/MRK overlapping kinase isoform X12

  6. XM_054376528.1 → XP_054232503.1  MAPK/MAK/MRK overlapping kinase isoform X9

  7. XM_054376526.1 → XP_054232501.1  MAPK/MAK/MRK overlapping kinase isoform X7

  8. XM_054376522.1 → XP_054232497.1  MAPK/MAK/MRK overlapping kinase isoform X3

  9. XM_054376521.1 → XP_054232496.1  MAPK/MAK/MRK overlapping kinase isoform X2

  10. XM_054376520.1 → XP_054232495.1  MAPK/MAK/MRK overlapping kinase isoform X1

  11. XM_054376530.1 → XP_054232505.1  MAPK/MAK/MRK overlapping kinase isoform X11

  12. XM_054376529.1 → XP_054232504.1  MAPK/MAK/MRK overlapping kinase isoform X10

RNA

  1. XR_008488890.1 RNA Sequence

  2. XR_008488889.1 RNA Sequence

  3. XR_008488888.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UQ07.1 GenPept UniProtKB/Swiss-Prot:Q9UQ07

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