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Nckap1 NCK-associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 58823, updated on 2-Nov-2024

Summary

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Official Symbol
Nckap1provided by RGD
Official Full Name
NCK-associated protein 1provided by RGD
Primary source
RGD:61939
See related
EnsemblRapid:ENSRNOG00000007518 AllianceGenome:RGD:61939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to contribute to small GTPase binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; cortical actin cytoskeleton organization; and positive regulation of cellular component organization. Predicted to act upstream of or within several processes, including apical protein localization; embryonic morphogenesis; and segmentation. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 858.2), Kidney (RPKM 696.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nckap1 in Genome Data Viewer
Location:
3q24
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (85824333..85898748, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (65417450..65491769, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (67725180..67804680, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486398 Neighboring gene uncharacterized LOC134486397 Neighboring gene small nucleolar RNA U3 Neighboring gene dual specificity phosphatase 19 Neighboring gene nucleoporin 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia. Afzal TA, et al. J Am Heart Assoc, 2016 Dec 7. PMID 27927633, Free PMC Article
  2. CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation. De Rubeis S, et al. Neuron, 2013 Sep 18. PMID 24050404, Free PMC Article
  3. Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. Chazeau A, et al. EMBO J, 2014 Dec 1. PMID 25293574, Free PMC Article
  4. Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. Kitamura T, et al. Biochem Biophys Res Commun, 1996 Feb 15. PMID 8605018
  5. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. Steffen A, et al. EMBO J, 2004 Feb 25. PMID 14765121, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rac protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apical protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within basal protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration involved in gastrulation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic foregut morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment or maintenance of actin cytoskeleton polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mesodermal cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within notochord development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within notochord morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paraxial mesoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paraxial mesoderm morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within zygotic determination of anterior/posterior axis, embryo ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCAR complex IEA
Inferred from Electronic Annotation
more info
  
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
  
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nck-associated protein 1
Names
NAP 1
membrane-associated protein HEM-2
p125Nap1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031618.1 → NP_113806.1  nck-associated protein 1

    See identical proteins and their annotated locations for NP_113806.1

    Status: VALIDATED

    Source sequence(s)
    BC092610, BC107935, CB586461, D84346
    UniProtKB/Swiss-Prot
    P55161
    UniProtKB/TrEMBL
    A0A8I5ZLZ9, A6HMN0
    Related
    ENSRNOP00000079055.1, ENSRNOT00000114653.2
    Conserved Domains (1) summary
    pfam09735
    Location:13 → 1122
    Nckap1; Membrane-associated apoptosis protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    85824333..85898748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105741.2 → XP_038961669.1  nck-associated protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P55161
    UniProtKB/TrEMBL
    A0A8I5ZSX9, A6HMN1
    Related
    ENSRNOP00000081784.1, ENSRNOT00000094898.2
    Conserved Domains (1) summary
    pfam09735
    Location:13 → 1128
    Nckap1; Membrane-associated apoptosis protein

  2. XM_039105743.2 → XP_038961671.1  nck-associated protein 1 isoform X3

    UniProtKB/Swiss-Prot
    P55161
    Conserved Domains (1) summary
    pfam09735
    Location:13 → 1120
    Nckap1; Membrane-associated apoptosis protein

  3. XM_039105742.2 → XP_038961670.1  nck-associated protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P55161
    Conserved Domains (1) summary
    pfam09735
    Location:13 → 1126
    Nckap1; Membrane-associated apoptosis protein

  4. XM_063284423.1 → XP_063140493.1  nck-associated protein 1 isoform X4

  5. XM_063284424.1 → XP_063140494.1  nck-associated protein 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55161.1 GenPept UniProtKB/Swiss-Prot:P55161

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