Eid1 EP300 interacting inhibitor of differentiation 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eid1provided by MGI
Official Full Name: EP300 interacting inhibitor of differentiation 1provided by MGI
Primary source: MGI:MGI:1889651
See related: Ensembl:ENSMUSG00000091337 AllianceGenome:MGI:1889651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cri1; EID-1; ORF12; PTD014; PNAS-22; 2610002K20Rik
Summary: Enables transcription corepressor activity. Predicted to be involved in cell differentiation and negative regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including heart; liver; lung; pancreas; and placenta. Orthologous to human EID1 (EP300 interacting inhibitor of differentiation 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.76 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (125515020..125517563)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (125673100..125675643)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EID1 suppresses lipid accumulation by inhibiting the expression of GPDH in 3T3-L1 preadipocytes.
Title: EID1 suppresses lipid accumulation by inhibiting the expression of GPDH in 3T3-L1 preadipocytes.
Eid1 knockout impeded the proliferation of neural stem cells.
Title: EID1 plays a crucial role in proliferation of neural stem cell.
Regulation of cell proliferation is the main functions of Eid1 in mice brain.
Title: Transcriptome profiling in Eid1-KO mice brain shows that Eid1 links cell proliferation in the brain.
palmitoylation modified E1A-like inhibitor of differentiation one (EID1) and this modification regulated EID1 degradation and CREB-binding protein (CBP)/p300 histone acetyltransferase activity at the switch between self-renewal and differentiation of neural stem cells.
Title: Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity.
Pcid2 is present in the CBP/p300-EID1 complex to control the switch balance of mouse and human embryonic stem cells through modulation of EID1 degradation.
Title: Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability.
This study supports Cri1 as the major locus controlling susceptibility following murine infection with C. rodentium, and suggests a cause of mortality common to the susceptible C3, C3Ou and FVB strains of mice.
Title: The Cri1 locus is the common genetic cause of susceptibility to Citrobacter rodentium infection in C3H and FVB mouse strains.
Cri1 does not control C. rodentium colonic hyperplasia
Title: Identification and characterization of Cri1, a locus controlling mortality during Citrobacter rodentium infection in mice.
EID-1 is expressed in the mouse testis, and its expression decreases during testis development. The results of the present study suggest that EID-1 can act as a repressor, regulating the function of SF-1.
Title: EID-1 interacts with orphan nuclear receptor SF-1 and represses its transactivation.
isolation of mouse E1A-like inhibitor of differentiation 1 (EID1) as a candidate coinhibitor for SHP
Title: A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone acetyltransferase binding	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: EP300-interacting inhibitor of differentiation 1

Names: CREBBP/EP300 inhibitory protein 1; E1A-like inhibitor of differentiation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.