RBM25 RNA binding motif protein 25 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RBM25provided by HGNC
Official Full Name: RNA binding motif protein 25provided by HGNC
Primary source: HGNC:HGNC:23244
See related: Ensembl:ENSG00000119707 MIM:612427; AllianceGenome:HGNC:23244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S164; NET52; RNPC7; Snu71; RED120; fSAP94
Summary: Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bone marrow (RPKM 31.7), lymph node (RPKM 25.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q24.2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (73058534..73123899)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (67264089..67329452)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (73525242..73590607)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA.
Title: Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA.
Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome.
Title: Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome.
Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma.
Title: Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma.
Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer.
Title: Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer.
RBM25 binds directly to circAMOTL1L and induces its biogenesis, whereas p53 regulates EMT via direct activation of RBM25 gene.
Title: Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.
controls the splicing of key genes, including those encoding the apoptotic regulator BCL-X and the MYC inhibitor BIN1
Title: The splicing factor RBM25 controls MYC activity in acute myeloid leukemia.
Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 = serine- and arginine-rich splicing factor 2)
Title: RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation.
Structure-guided mutagenesis reveals a positively charged nucleic-acid-binding surface in the RBM25 PWI domain
Title: Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region.
RBM25/LUC7L3-mediated abnormal SCN5A mRNA splicing reduced Na+ channel current 91.1+/-9.3% to a range known to cause sudden death.
Title: Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.
These data suggest a novel mode for Bcl-x(S) 5' ss activation in which binding of RBM25 with exonic element CGGGCA may stabilize the pre-mRNA-U1 snRNP through interactions with hLuc7A.
Title: Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of RNA binding motif protein 25 (RBM25) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S1274 (e-PCR)
- UniSTS:154643

G38164 (e-PCR)
- UniSTS:66350

G60429 (e-PCR)
- UniSTS:137535

D14S77 (e-PCR)
- UniSTS:49483

RH91841 (e-PCR)
- UniSTS:92751

SHGC-154192 (e-PCR)
- UniSTS:178009

RH70188 (e-PCR)
- UniSTS:11866

G38224 (e-PCR)
- UniSTS:63076

RH91914 (e-PCR)
- UniSTS:88191

G38130 (e-PCR)
- UniSTS:22918

A007D07 (e-PCR)
- UniSTS:36498

SGC31601 (e-PCR)
- UniSTS:64928

G35872 (e-PCR)
- UniSTS:62121

G38145 (e-PCR)
- UniSTS:3242

RH47401 (e-PCR)
- UniSTS:82872

G38202 (e-PCR)
- UniSTS:73918

D14S1365 (e-PCR)
- UniSTS:473802

G38197 (e-PCR)
- UniSTS:14807

G38180 (e-PCR)
- UniSTS:25074

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: RNA-binding protein 25

Names: Arg/Glu/Asp-rich protein, 120 kDa; RNA-binding region (RNP1, RRM) containing 7; RNA-binding region-containing protein 7; U1 small nuclear ribonucleoprotein 1SNRP homolog; arg/Glu/Asp-rich protein of 120 kDa; functional spliceosome-associated protein 94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021239.3 → NP_067062.1 RNA-binding protein 25

See identical proteins and their annotated locations for NP_067062.1

Status: VALIDATED

Source sequence(s)

AC004858, AL442663

Consensus CDS

CCDS32113.1

UniProtKB/Swiss-Prot

A0PJL9, B2RNA8, B3KT03, P49756, Q2TA72, Q5XJ17, Q6P665, Q9H6A1, Q9UEQ5, Q9UIE9

Related

ENSP00000261973.7, ENST00000261973.12

Conserved Domains (2) summary

smart00311
Location:763 → 836

PWI; domain in splicing factors

cd12446
Location:87 → 169

RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

73058534..73123899

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011537044.4 → XP_011535346.1 RNA-binding protein 25 isoform X1

See identical proteins and their annotated locations for XP_011535346.1

UniProtKB/Swiss-Prot

A0PJL9, B2RNA8, B3KT03, P49756, Q2TA72, Q5XJ17, Q6P665, Q9H6A1, Q9UEQ5, Q9UIE9

Conserved Domains (2) summary

smart00311
Location:763 → 836

PWI; domain in splicing factors

cd12446
Location:87 → 169

RRM_RBM25; RNA recognition motif (RRM) found in eukaryotic RNA-binding protein 25 and similar proteins
XM_047431641.1 → XP_047287597.1 RNA-binding protein 25 isoform X2