ZNF77 zinc finger protein 77 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF77provided by HGNC
Official Full Name: zinc finger protein 77provided by HGNC
Primary source: HGNC:HGNC:13150
See related: Ensembl:ENSG00000175691 MIM:194551; AllianceGenome:HGNC:13150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: pT1
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thyroid (RPKM 1.9), testis (RPKM 1.7) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 19p13.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (2933218..2950625, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (2906814..2918459, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (2933216..2944969, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZNF77 as a key controller of Aspergillus colonization and suggest its utility as a risk-marker for patient stratification.
Title: Lung colonization by Aspergillus fumigatus is controlled by ZNF77.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 77

Names: ZNFpT1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426550.1 → NP_001413479.1 zinc finger protein 77 isoform 2

Status: VALIDATED

Source sequence(s)

AC006277, AC011559
NM_001426551.1 → NP_001413480.1 zinc finger protein 77 isoform 2

Status: VALIDATED

Source sequence(s)

CP068259
NM_021217.3 → NP_067040.1 zinc finger protein 77 isoform 1

See identical proteins and their annotated locations for NP_067040.1

Status: VALIDATED

Source sequence(s)

AC006277, AC011559

Consensus CDS

CCDS12099.1

UniProtKB/Swiss-Prot

Q15935, Q86XJ3, Q9NPP0

Related

ENSP00000319053.3, ENST00000314531.5

Conserved Domains (3) summary

COG5048
Location:237 → 544

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:410 → 430

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:4 → 44

KRAB; KRAB box