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ZNF71 zinc finger protein 71 [ Homo sapiens (human) ]

Gene ID: 58491, updated on 28-Oct-2024

Summary

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Official Symbol
ZNF71provided by HGNC
Official Full Name
zinc finger protein 71provided by HGNC
Primary source
HGNC:HGNC:13141
See related
Ensembl:ENSG00000197951 MIM:194545; AllianceGenome:HGNC:13141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZFIT
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in endometrium (RPKM 1.6), fat (RPKM 1.6) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF71 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56595302..56624486)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59689707..59718582)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57106670..57135854)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904777 Neighboring gene sialic acid binding Ig like lectin 31, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11070 Neighboring gene ZNF71-SMIM17 readthrough (NMD candidate) Neighboring gene ReSE screen-validated silencer GRCh37_chr19:57128366-57128584 Neighboring gene Sharpr-MPRA regulatory region 15209 Neighboring gene small integral membrane protein 17 Neighboring gene zinc finger protein 835

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer. Ye Q, et al. Int J Mol Sci, 2021 Apr 4. PMID 33916522, Free PMC Article
  2. A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha. Mataki C, et al. J Atheroscler Thromb, 2000. PMID 11426589
  3. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Aubry M, et al. Genomics, 1992 Jul. PMID 1639391
  4. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. Kim JH, et al. PLoS One, 2013. PMID 23967269, Free PMC Article
  5. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer.
    Title: Molecular Analysis of ZNF71 KRAB in Non-Small-Cell Lung Cancer.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF71-SMIM17

Readthrough gene: ZNF71-SMIM17, Included gene: SMIM17

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
endothelial zinc finger protein induced by tumor necrosis factor alpha
Names
Kruppel-related zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370214.1 → NP_001357143.1  endothelial zinc finger protein induced by tumor necrosis factor alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA580897, AC007228, AF269249, BC014280, BQ932244, CA416578, CR989498, HY138791
    Consensus CDS
    CCDS12947.1
    UniProtKB/Swiss-Prot
    Q15919, Q9NQZ8, Q9UC09, Q9UQD3
    Related
    ENSP00000520559.1, ENST00000716547.1
    Conserved Domains (2) summary
    COG5048
    Location:110 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001370215.1 → NP_001357144.1  endothelial zinc finger protein induced by tumor necrosis factor alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA580897, AC007228, AF269249, BC014280, BQ932244, CA416578, CR989498, HY138791
    Consensus CDS
    CCDS92695.1
    UniProtKB/TrEMBL
    M0R0C0
    Related
    ENSP00000471138.2, ENST00000599599.7
    Conserved Domains (3) summary
    COG5048
    Location:170 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 54
    KRAB; KRAB box

  3. NM_021216.5 → NP_067039.1  endothelial zinc finger protein induced by tumor necrosis factor alpha isoform 1

    See identical proteins and their annotated locations for NP_067039.1

    Status: VALIDATED

    Source sequence(s)
    AC007228, AF269249, BC014280, BP377051
    Consensus CDS
    CCDS12947.1
    UniProtKB/Swiss-Prot
    Q15919, Q9NQZ8, Q9UC09, Q9UQD3
    Related
    ENSP00000328245.5, ENST00000328070.10
    Conserved Domains (2) summary
    COG5048
    Location:110 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272 → 292
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56595302..56624486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59689707..59718582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQZ8.1 GenPept UniProtKB/Swiss-Prot:Q9NQZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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