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PEX5 peroxisomal biogenesis factor 5 [ Homo sapiens (human) ]

Gene ID: 5830, updated on 7-Apr-2024

Summary

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Official Symbol
PEX5provided by HGNC
Official Full Name
peroxisomal biogenesis factor 5provided by HGNC
Primary source
HGNC:HGNC:9719
See related
Ensembl:ENSG00000139197 MIM:600414; AllianceGenome:HGNC:9719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PXR1; PBD2A; PBD2B; PTS1R; RCDP5; PTS1-BP
Summary
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in testis (RPKM 16.9), brain (RPKM 10.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
12p13.31
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7188653..7218574)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7201809..7231939)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7341249..7371170)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7283265-7283766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4199 Neighboring gene retinol binding protein 5 Neighboring gene calsyntenin 3 Neighboring gene Sharpr-MPRA regulatory region 5519 Neighboring gene uncharacterized LOC124902869 Neighboring gene MPRA-validated peak1553 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7340767-7341268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:7341269-7341768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5916 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342139-7342855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:7342856-7343571 Neighboring gene acyl-CoA synthetase medium chain family member 6 pseudogene Neighboring gene MPRA-validated peak1554 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr12:7434099-7434654 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:7469109-7470308 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:7476238-7477437 Neighboring gene acyl-CoA synthetase medium chain family member 4 Neighboring gene CD163 molecule like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance. Niu X, et al. Int J Biol Sci, 2022. PMID 35002522, Free PMC Article
  2. PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation. Eun SY, et al. Exp Mol Med, 2018 Apr 6. PMID 29622767, Free PMC Article
  3. Functional variants inPXRare associated with colorectal cancer susceptibility in Chinese populations. Ni H, et al. Cancer Epidemiol, 2015 Dec. PMID 26547791
  4. A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform. Barøy T, et al. Hum Mol Genet, 2015 Oct 15. PMID 26220973
  5. Molecular recognition of PTS-1 cargo proteins by Pex5p: implications for protein mistargeting in primary hyperoxaluria. Mesa-Torres N, et al. Biomolecules, 2015 Feb 13. PMID 25689234, Free PMC Article

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and Validation of a PEX5-Dependent Signature for Prognostic Prediction in Glioma.
    Title: Identification and Validation of a PEX5-Dependent Signature for Prognostic Prediction in Glioma.
  2. Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance.
    Title: Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance.
  3. A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.
    Title: A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes.
  4. Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
    Title: Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
  5. Mitotic phosphorylation of Pex14p regulates peroxisomal import machinery.
    Title: Mitotic phosphorylation of Pex14p regulates peroxisomal import machinery.
  6. The interactions with the docking proteins were independent of the PEX5 ubiquitination status whereas the interactions with the receptor export machinery (REM) components were increased when PEX5 is ubiquitinated
    Title: Chemically monoubiquitinated PEX5 binds to the components of the peroxisomal docking and export machinery.
  7. These data suggest that PEX5 may be a critical regulator of lysosomal gene expression and autophagy through the mTOR-TFEB-autophagy axis under nutrient deprivation.
    Title: PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation.
  8. This study provides evidence suggesting that monoubiquitinated PEX5 interacts directly with both PEX1 and PEX6 through its ubiquitin moiety and that the PEX5 polypeptide chain is globally unfolded during the ATP-dependent extraction event.
    Title: Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.
  9. Data suggest that P7BP2 is localized to peroxisomes by binding to PEX5 via PEX7 in manner dependent on apparent PTS2 (type 2 peroxisomal targeting signal peptide) in N-terminal region of P7BP2; the PTS2 is subsequently cleaved off in peroxisomes. (P7BP2 = PEX7-binding protein-2; PEX5 = peroxisomal biogenesis factor-5; PEX7 = peroxisomal biogenesis factor-7)
    Title: A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein.
  10. these findings lend credit to the idea that inefficient catalase import, when coupled with the role of PEX5 as a redox-regulated import receptor, constitutes a cellular defense mechanism to combat oxidative insults of extra-peroxisomal origin.
    Title: The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Peroxisome biogenesis disorder 2A (Zellweger)
MedGen: C3550273 OMIM: 214110 GeneReviews: Not available
Compare labs
Peroxisome biogenesis disorder 2B
MedGen: C3550234 OMIM: 202370 GeneReviews: Zellweger Spectrum Disorder
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Rhizomelic chondrodysplasia punctata type 5
MedGen: C4225237 OMIM: 616716 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ50634, FLJ50721, FLJ51948

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peroxisome matrix targeting signal-1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxisome matrix targeting signal-1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxisome matrix targeting signal-1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peroxisome membrane targeting sequence binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peroxisome targeting sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein carrier chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein carrier chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cerebral cortex cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in cerebral cortex neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuromuscular process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
  
involved_in pexophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome matrix IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into peroxisome matrix IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into peroxisome matrix NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein import into peroxisome matrix, docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into peroxisome matrix, docking IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into peroxisome matrix, receptor recycling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into peroxisome matrix, substrate release IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into peroxisome matrix, substrate release ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein import into peroxisome membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in peroxisomal matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in peroxisomal membrane HDA PubMed 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peroxisomal biogenesis factor 5
Names
PTS1 receptor
peroxin-5
peroxisomal C-terminal targeting signal import receptor
peroxisomal import receptor 5
peroxisomal targeting signal 1 (SKL type) receptor
peroxisomal targeting signal 1 receptor
peroxisomal targeting signal import receptor
peroxisomal targeting signal receptor 1
peroxisome receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008448.1 RefSeqGene

    Range
    5524..27297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000319.5 → NP_000310.2  peroxisomal biogenesis factor 5 isoform b

    See identical proteins and their annotated locations for NP_000310.2

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS8576.1
    UniProtKB/TrEMBL
    A0A0S2Z480, B4DR50
    Related
    ENSP00000266564.3, ENST00000266564.7
    Conserved Domains (3) summary
    sd00006
    Location:480 → 508
    TPR; TPR repeat [structural motif]
    cl02686
    Location:297 → 332
    PRY; SPRY-associated domain
    cl26002
    Location:332 → 575
    TPR_11; TPR repeat

  2. NM_001131023.2 → NP_001124495.1  peroxisomal biogenesis factor 5 isoform a

    See identical proteins and their annotated locations for NP_001124495.1

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44822.1
    UniProtKB/TrEMBL
    B4DR50
    Related
    ENSP00000407401.2, ENST00000434354.6
    Conserved Domains (4) summary
    sd00006
    Location:503 → 531
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:503 → 536
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:502 → 568
    TPR_11; TPR repeat
    cl02686
    Location:320 → 355
    PRY; SPRY-associated domain

  3. NM_001131024.2 → NP_001124496.1  peroxisomal biogenesis factor 5 isoform c

    See identical proteins and their annotated locations for NP_001124496.1

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Related
    ENSP00000266563.5, ENST00000266563.9
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  4. NM_001131025.2 → NP_001124497.1  peroxisomal biogenesis factor 5 isoform d

    See identical proteins and their annotated locations for NP_001124497.1

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Related
    ENSP00000410159.2, ENST00000420616.6
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  5. NM_001131026.2 → NP_001124498.1  peroxisomal biogenesis factor 5 isoform d

    See identical proteins and their annotated locations for NP_001124498.1

    Status: REVIEWED

    Source sequence(s)
    AI252784, AK292256
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Related
    ENSP00000400647.2, ENST00000455147.6
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  6. NM_001300789.3 → NP_001287718.2  peroxisomal biogenesis factor 5 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  7. NM_001351124.3 → NP_001338053.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  8. NM_001351126.2 → NP_001338055.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  9. NM_001351127.2 → NP_001338056.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  10. NM_001351128.2 → NP_001338057.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  11. NM_001351130.3 → NP_001338059.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  12. NM_001351131.2 → NP_001338060.1  peroxisomal biogenesis factor 5 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  13. NM_001351132.2 → NP_001338061.1  peroxisomal biogenesis factor 5 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Related
    ENSP00000502374.1, ENST00000675855.1
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  14. NM_001351133.2 → NP_001338062.1  peroxisomal biogenesis factor 5 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  15. NM_001351134.2 → NP_001338063.1  peroxisomal biogenesis factor 5 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  16. NM_001351135.3 → NP_001338064.2  peroxisomal biogenesis factor 5 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC018653
    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:324 → 561
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:466 → 494
    TPR; TPR repeat [structural motif]
    cl02686
    Location:283 → 318
    PRY; SPRY-associated domain

  17. NM_001351136.2 → NP_001338065.1  peroxisomal biogenesis factor 5 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC018653
    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (2) summary
    sd00006
    Location:485 → 513
    TPR; TPR repeat [structural motif]
    cl26002
    Location:343 → 580
    TPR_11; TPR repeat

  18. NM_001351137.3 → NP_001338066.2  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  19. NM_001351138.2 → NP_001338067.1  peroxisomal biogenesis factor 5 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC018653
    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:324 → 561
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:466 → 494
    TPR; TPR repeat [structural motif]
    cl02686
    Location:283 → 318
    PRY; SPRY-associated domain

  20. NM_001351139.2 → NP_001338068.1  peroxisomal biogenesis factor 5 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC018653
    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:295 → 538
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:443 → 471
    TPR; TPR repeat [structural motif]
    cl02686
    Location:260 → 295
    PRY; SPRY-associated domain

  21. NM_001351140.2 → NP_001338069.1  peroxisomal biogenesis factor 5 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC018653
    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:295 → 538
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:443 → 471
    TPR; TPR repeat [structural motif]
    cl02686
    Location:260 → 295
    PRY; SPRY-associated domain

  22. NM_001374645.1 → NP_001361574.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  23. NM_001374646.1 → NP_001361575.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  24. NM_001374647.2 → NP_001361576.1  peroxisomal biogenesis factor 5 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44823.1
    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:346 → 583
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:488 → 516
    TPR; TPR repeat [structural motif]
    cl02686
    Location:305 → 340
    PRY; SPRY-associated domain

  25. NM_001374648.2 → NP_001361577.1  peroxisomal biogenesis factor 5 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC018653
    Consensus CDS
    CCDS44824.1
    UniProtKB/TrEMBL
    A0A0S2Z4F3, B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:309 → 546
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:451 → 479
    TPR; TPR repeat [structural motif]
    cl02686
    Location:268 → 303
    PRY; SPRY-associated domain

  26. NM_001374649.2 → NP_001361578.1  peroxisomal biogenesis factor 5 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC018653
    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (3) summary
    TIGR02917
    Location:295 → 538
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:443 → 471
    TPR; TPR repeat [structural motif]
    cl02686
    Location:260 → 295
    PRY; SPRY-associated domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    7188653..7218574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429262.1 → XP_047285218.1  peroxisomal biogenesis factor 5 isoform X5

  2. XM_017019748.2 → XP_016875237.1  peroxisomal biogenesis factor 5 isoform X5

    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (4) summary
    sd00006
    Location:503 → 531
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:503 → 536
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:502 → 568
    TPR_11; TPR repeat
    cl02686
    Location:320 → 355
    PRY; SPRY-associated domain

  3. XM_047429257.1 → XP_047285213.1  peroxisomal biogenesis factor 5 isoform X1

  4. XM_047429259.1 → XP_047285215.1  peroxisomal biogenesis factor 5 isoform X3

    UniProtKB/TrEMBL
    B4E0T2
    Related
    ENSP00000391601.2, ENST00000412720.6

  5. XM_011520795.2 → XP_011519097.1  peroxisomal biogenesis factor 5 isoform X5

    See identical proteins and their annotated locations for XP_011519097.1

    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (4) summary
    sd00006
    Location:503 → 531
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:503 → 536
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:502 → 568
    TPR_11; TPR repeat
    cl02686
    Location:320 → 355
    PRY; SPRY-associated domain

  6. XM_047429267.1 → XP_047285223.1  peroxisomal biogenesis factor 5 isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z480

  7. XM_011520793.3 → XP_011519095.1  peroxisomal biogenesis factor 5 isoform X1

    See identical proteins and their annotated locations for XP_011519095.1

    UniProtKB/TrEMBL
    B4DR50
    Conserved Domains (4) summary
    sd00006
    Location:524 → 552
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:524 → 557
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:523 → 589
    TPR_11; TPR repeat
    cl02686
    Location:341 → 376
    PRY; SPRY-associated domain

  8. XM_047429258.1 → XP_047285214.1  peroxisomal biogenesis factor 5 isoform X2

  9. XM_047429263.1 → XP_047285219.1  peroxisomal biogenesis factor 5 isoform X4

  10. XM_047429268.1 → XP_047285224.1  peroxisomal biogenesis factor 5 isoform X7

  11. XM_047429265.1 → XP_047285221.1  peroxisomal biogenesis factor 5 isoform X5

    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1

  12. XM_047429260.1 → XP_047285216.1  peroxisomal biogenesis factor 5 isoform X5

  13. XM_047429270.1 → XP_047285226.1  peroxisomal biogenesis factor 5 isoform X8

  14. XM_047429266.1 → XP_047285222.1  peroxisomal biogenesis factor 5 isoform X9

  15. XM_047429264.1 → XP_047285220.1  peroxisomal biogenesis factor 5 isoform X6

  16. XM_047429269.1 → XP_047285225.1  peroxisomal biogenesis factor 5 isoform X8

RNA

  1. XR_007063107.1 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160008.1 Reference GRCh38.p14 PATCHES

    Range
    116339..146260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332535.1 → XP_054188510.1  peroxisomal biogenesis factor 5 isoform X5

  2. XM_054332534.1 → XP_054188509.1  peroxisomal biogenesis factor 5 isoform X5

  3. XM_054332529.1 → XP_054188504.1  peroxisomal biogenesis factor 5 isoform X1

  4. XM_054332531.1 → XP_054188506.1  peroxisomal biogenesis factor 5 isoform X3

    UniProtKB/TrEMBL
    B4E0T2

  5. XM_054332532.1 → XP_054188507.1  peroxisomal biogenesis factor 5 isoform X5

  6. XM_054332540.1 → XP_054188515.1  peroxisomal biogenesis factor 5 isoform X6

    UniProtKB/TrEMBL
    A0A0S2Z480

  7. XM_054332528.1 → XP_054188503.1  peroxisomal biogenesis factor 5 isoform X1

  8. XM_054332530.1 → XP_054188505.1  peroxisomal biogenesis factor 5 isoform X2

  9. XM_054332536.1 → XP_054188511.1  peroxisomal biogenesis factor 5 isoform X4

  10. XM_054332541.1 → XP_054188516.1  peroxisomal biogenesis factor 5 isoform X7

  11. XM_054332538.1 → XP_054188513.1  peroxisomal biogenesis factor 5 isoform X5

    UniProtKB/Swiss-Prot
    A8K891, B4DZ45, B7ZAD5, D3DUT8, P50542, Q15115, Q15266, Q96FN7
    UniProtKB/TrEMBL
    A0A0S2Z4H1

  12. XM_054332533.1 → XP_054188508.1  peroxisomal biogenesis factor 5 isoform X5

  13. XM_054332543.1 → XP_054188518.1  peroxisomal biogenesis factor 5 isoform X8

  14. XM_054332539.1 → XP_054188514.1  peroxisomal biogenesis factor 5 isoform X9

  15. XM_054332537.1 → XP_054188512.1  peroxisomal biogenesis factor 5 isoform X6

  16. XM_054332542.1 → XP_054188517.1  peroxisomal biogenesis factor 5 isoform X8

RNA

  1. XR_008485777.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    7201809..7231939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372765.1 → XP_054228740.1  peroxisomal biogenesis factor 5 isoform X5

  2. XM_054372764.1 → XP_054228739.1  peroxisomal biogenesis factor 5 isoform X5

  3. XM_054372760.1 → XP_054228735.1  peroxisomal biogenesis factor 5 isoform X10

  4. XM_054372762.1 → XP_054228737.1  peroxisomal biogenesis factor 5 isoform X1

  5. XM_054372773.1 → XP_054228748.1  peroxisomal biogenesis factor 5 isoform X5

  6. XM_054372769.1 → XP_054228744.1  peroxisomal biogenesis factor 5 isoform X6

  7. XM_054372759.1 → XP_054228734.1  peroxisomal biogenesis factor 5 isoform X10

  8. XM_054372761.1 → XP_054228736.1  peroxisomal biogenesis factor 5 isoform X11

  9. XM_054372766.1 → XP_054228741.1  peroxisomal biogenesis factor 5 isoform X2

  10. XM_054372770.1 → XP_054228745.1  peroxisomal biogenesis factor 5 isoform X13

  11. XM_054372768.1 → XP_054228743.1  peroxisomal biogenesis factor 5 isoform X5

  12. XM_054372763.1 → XP_054228738.1  peroxisomal biogenesis factor 5 isoform X5

  13. XM_054372772.1 → XP_054228747.1  peroxisomal biogenesis factor 5 isoform X8

  14. XM_054372767.1 → XP_054228742.1  peroxisomal biogenesis factor 5 isoform X12

  15. XM_054372771.1 → XP_054228746.1  peroxisomal biogenesis factor 5 isoform X14

RNA

  1. XR_008488652.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50542.3 GenPept UniProtKB/Swiss-Prot:P50542

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