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Il20 interleukin 20 [ Mus musculus (house mouse) ]

Gene ID: 58181, updated on 11-Nov-2024

Summary

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Official Symbol
Il20provided by MGI
Official Full Name
interleukin 20provided by MGI
Primary source
MGI:MGI:1890473
See related
Ensembl:ENSMUSG00000026416 AllianceGenome:MGI:1890473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
If2d; Zcyto10
Summary
Enables cytokine activity; interleukin-20 receptor binding activity; and interleukin-22 receptor binding activity. Acts upstream of or within positive regulation of osteoclast differentiation. Located in extracellular space. Is expressed in Harderian gland; ductus deferens; epididymis; prostate gland; and skin. Human ortholog(s) of this gene implicated in psoriasis. Orthologous to human IL20 (interleukin 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Il20 in Genome Data Viewer
Location:
1 E4; 1 56.89 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130834722..130839033, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130906985..130911296, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9184 Neighboring gene STARR-positive B cell enhancer ABC_E9478 Neighboring gene Fc fragment of IgM receptor Neighboring gene interleukin 24 Neighboring gene STARR-seq mESC enhancer starr_02206 Neighboring gene interleukin 19 Neighboring gene predicted gene, 41952

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs. Tritsaris K, et al. Proc Natl Acad Sci U S A, 2007 Sep 25. PMID 17878297, Free PMC Article
  2. Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models. Hsu YH, et al. J Immunol, 2012 Feb 15. PMID 22238453
  3. Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice. Mayer C, et al. PLoS One, 2015. PMID 26162095, Free PMC Article
  4. AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin. Garcin G, et al. J Invest Dermatol, 2015 Nov. PMID 26176762
  5. Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis. Hsu YH, et al. Sci Rep, 2016 Apr 14. PMID 27075747, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
    Title: IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
  2. IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
    Title: IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
  3. IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
    Title: IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
  4. IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
    Title: IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
  5. our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
    Title: IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.
  6. The authors conclude that IL-20 affects bone formation and downregulates osteoblastogenesis by modulating sclerostin, osterix, RUNX2, and osteoprotegerin on osteoblasts.
    Title: Anti-IL-20 monoclonal antibody promotes bone fracture healing through regulating IL-20-mediated osteoblastogenesis.
  7. Data show that interleukin 20 (IL-20) is expressed in type 2 diabetic db/db islets and contributes to inflammation.
    Title: Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice.
  8. IL-20 is primarily up regulated in psoriatic skin at the post-transcriptional level.
    Title: AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin.
  9. our results suggest that IL-20 plays pivotal roles in the tumor progression of breast cancer. IL-20 expression in breast cancer tissue is associated with a poor clinical outcome.
    Title: Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.
  10. novel effects of IL-20 on mesangial cells and its association with lupus nephritis.
    Title: Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC130536

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables interleukin-20 receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-20 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-22 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in hemopoiesis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interleukin-20
Names
IL-20
cytokine Zcyto10
four alpha helix cytokine ZCYTO10
four helix bundle cytokine 10
interferon 2d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311091.1 → NP_001298020.1  interleukin-20 isoform 2

    See identical proteins and their annotated locations for NP_001298020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF224267, BB064801
    Consensus CDS
    CCDS78673.1
    UniProtKB/TrEMBL
    Q2THG5
    Related
    ENSMUSP00000141088.2, ENSMUST00000188581.2
    Conserved Domains (1) summary
    cl02501
    Location:58 → 151
    IL10; Interleukin 10

  2. NM_021380.2 → NP_067355.1  interleukin-20 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067355.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF224267, BB064801
    Consensus CDS
    CCDS15263.1
    UniProtKB/Swiss-Prot
    Q9JKV9
    UniProtKB/TrEMBL
    Q2NKI0
    Related
    ENSMUSP00000027673.5, ENSMUST00000027673.11
    Conserved Domains (1) summary
    cl02501
    Location:39 → 173
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130834722..130839033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKV9.1 GenPept UniProtKB/Swiss-Prot:Q9JKV9

Gene LinkOut

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