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Rgs20 regulator of G-protein signaling 20 [ Mus musculus (house mouse) ]

Gene ID: 58175, updated on 18-Sep-2024

Summary

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Official Symbol
Rgs20provided by MGI
Official Full Name
regulator of G-protein signaling 20provided by MGI
Primary source
MGI:MGI:1929866
See related
Ensembl:ENSMUSG00000002459 AllianceGenome:MGI:1929866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rgsz1; 2900073E09Rik
Summary
Predicted to enable GTPase activator activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in trans-Golgi network. Is expressed in ventricular layer. Orthologous to human RGS20 (regulator of G protein signaling 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.4), frontal lobe adult (RPKM 4.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Rgs20 in Genome Data Viewer
Location:
1 A1; 1 1.8 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4976342..5140528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4909573..5070299, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00043 Neighboring gene predicted gene, 57794 Neighboring gene transcription elongation factor A (SII) 1 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00045 Neighboring gene STARR-seq mESC enhancer starr_00046 Neighboring gene STARR-seq mESC enhancer starr_00048 Neighboring gene STARR-seq mESC enhancer starr_00049 Neighboring gene predicted gene 16041 Neighboring gene STARR-seq mESC enhancer starr_00050 Neighboring gene STARR-seq mESC enhancer starr_00051 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 17 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit H Neighboring gene STARR-seq mESC enhancer starr_00054 Neighboring gene STARR-seq mESC enhancer starr_00056 Neighboring gene STARR-seq mESC enhancer starr_00057 Neighboring gene STARR-seq mESC enhancer starr_00060 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward. Sakloth F, et al. Mol Pharmacol, 2023 Jan. PMID 36310031, Free PMC Article
  2. Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway. Gaspari S, et al. Proc Natl Acad Sci U S A, 2018 Feb 27. PMID 29440403, Free PMC Article
  3. RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20. Barker SA, et al. Genomics, 2001 Dec. PMID 11735229
  4. The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. Nixon AB, et al. J Biol Chem, 2002 May 17. PMID 11882662
  5. A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Nagata Y, et al. Blood, 2001 May 15. PMID 11342430

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward.
    Title: A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward.
  2. RGSz1 function suppression optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/beta-catenin pathway
    Title: Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.
  3. Analysis of in vitro microtubule polymerization/depolymerization showed that binding of RGSZ1 to SCG10 effectively blocked the ability of SCG10 to induce microtubule disassembly
    Title: The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC151302, MGC151306

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 20
Names
regulator of G-protein signaling Z1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177795.1 → NP_001171266.1  regulator of G-protein signaling 20 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC102311, AK078208, BI730177, BI735670
    Consensus CDS
    CCDS48213.1
    UniProtKB/TrEMBL
    E9Q720
    Related
    ENSMUSP00000113398.2, ENSMUST00000118000.8
    Conserved Domains (1) summary
    cl02565
    Location:205 → 360
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_001290372.1 → NP_001277301.1  regulator of G-protein signaling 20 isoform 3

    See identical proteins and their annotated locations for NP_001277301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC102242, AC102311, AK158864
    Consensus CDS
    CCDS69859.1
    UniProtKB/TrEMBL
    Q8C5J7
    Related
    ENSMUSP00000113324.2, ENSMUST00000119256.8
    Conserved Domains (1) summary
    cl02565
    Location:41 → 196
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. NM_021374.5 → NP_067349.2  regulator of G-protein signaling 20 isoform 2

    See identical proteins and their annotated locations for NP_067349.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The resulting isoform (2) is shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC102311, AK158864, BC116925, BY127242
    Consensus CDS
    CCDS14807.1
    UniProtKB/Swiss-Prot
    Q14A97, Q3TY63, Q9CUV8, Q9QZB1, Q9QZB2
    Related
    ENSMUSP00000002533.9, ENSMUST00000002533.15
    Conserved Domains (1) summary
    cl02565
    Location:72 → 227
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    4976342..5140528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152522.1 → XP_036008415.1  regulator of G-protein signaling 20 isoform X2

    UniProtKB/TrEMBL
    Q8C5J7
    Conserved Domains (1) summary
    cl02565
    Location:41 → 196
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. XM_036152516.1 → XP_036008409.1  regulator of G-protein signaling 20 isoform X1

    UniProtKB/Swiss-Prot
    Q14A97, Q3TY63, Q9CUV8, Q9QZB1, Q9QZB2
    Conserved Domains (1) summary
    cl02565
    Location:72 → 227
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. XM_011238400.2 → XP_011236702.1  regulator of G-protein signaling 20 isoform X2

    See identical proteins and their annotated locations for XP_011236702.1

    UniProtKB/TrEMBL
    Q8C5J7
    Conserved Domains (1) summary
    cl02565
    Location:41 → 196
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  4. XM_006495554.3 → XP_006495617.1  regulator of G-protein signaling 20 isoform X4

    Conserved Domains (1) summary
    cl02565
    Location:17 → 139
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  5. XM_036152539.1 → XP_036008432.1  regulator of G-protein signaling 20 isoform X5

    Conserved Domains (1) summary
    cl02565
    Location:1 → 110
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  6. XM_036152535.1 → XP_036008428.1  regulator of G-protein signaling 20 isoform X4

    Conserved Domains (1) summary
    cl02565
    Location:17 → 139
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  7. XM_011238401.4 → XP_011236703.1  regulator of G-protein signaling 20 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZB1.1 GenPept UniProtKB/Swiss-Prot:Q9QZB1

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