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cd74a CD74 molecule, major histocompatibility complex, class II invariant chain a [ Danio rerio (zebrafish) ]

Gene ID: 58113, updated on 10-Nov-2024

Summary

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Official Symbol
cd74aprovided by ZNC
Official Full Name
CD74 molecule, major histocompatibility complex, class II invariant chain aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000901-1
See related
Ensembl:ENSDARG00000009087 AllianceGenome:ZFIN:ZDB-GENE-000901-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
iclp1; Iclp-1; wu:fb11f09; wu:fb12a01; wu:fb13d06; wu:fk94e07
Summary
Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within several processes, including T cell activation involved in immune response; dendritic cell antigen processing and presentation; and neuromast development. Located in cell surface. Is expressed in dendritic cell; otic vesicle; pectoral fin bud; pharyngeal arch; and sensory system. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See cd74a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (3038597..3052361)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (2787480..2801244)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene bicaudal C homolog 2 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a Neighboring gene si:dkey-201i24.3 Neighboring gene solute carrier family 35 member A4 Neighboring gene HMG box domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules. Dijkstra JM, et al. Immunogenetics, 2019 Mar. PMID 30377750
  2. Identification of dendritic antigen-presenting cells in the zebrafish. Lugo-Villarino G, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20733076, Free PMC Article
  3. The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio. Shen YC, et al. Dev Biol, 2012 Mar 1. PMID 22210003, Free PMC Article
  4. Transcriptome Analysis Reveals Increases in Visceral Lipogenesis and Storage and Activation of the Antigen Processing and Presentation Pathway during the Mouth-Opening Stage in Zebrafish Larvae. Xu H, et al. Int J Mol Sci, 2017 Jul 31. PMID 28758957, Free PMC Article
  5. Effects of acute and chronic arecoline in adult zebrafish: Anxiolytic-like activity, elevated brain monoamines and the potential role of microglia. Serikuly N, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2021 Jan 10. PMID 32454162

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables MHC class II protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables macrophage migration inhibitory factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables macrophage migration inhibitory factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within T cell activation involved in immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antigen processing and presentation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendritic cell antigen processing and presentation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuromast development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of type 2 immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CD74 molecule, major histocompatibility complex, class II invariant chain a
Names
MHC II
invariant chain-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131590.2 → NP_571665.1  CD74 molecule, major histocompatibility complex, class II invariant chain a

    See identical proteins and their annotated locations for NP_571665.1

    Status: VALIDATED

    Source sequence(s)
    CU468924
    UniProtKB/TrEMBL
    Q6P0V5, Q9PUT2
    Related
    ENSDARP00000002547.6, ENSDART00000026021.8
    Conserved Domains (2) summary
    cd00191
    Location:177 → 234
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam09307
    Location:4 → 109
    MHC2-interact; CLIP, MHC2 interacting

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    3038597..3052361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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