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PTPRM protein tyrosine phosphatase receptor type M [ Homo sapiens (human) ]

Gene ID: 5797, updated on 11-Apr-2024

Summary

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Official Symbol
PTPRMprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Mprovided by HGNC
Primary source
HGNC:HGNC:9675
See related
Ensembl:ENSG00000173482 MIM:176888; AllianceGenome:HGNC:9675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 28.8), thyroid (RPKM 25.6) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See PTPRM in Genome Data Viewer
Location:
18p11.23
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (7567316..8406856)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (7730572..8570006)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (7567314..8406854)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112577592 Neighboring gene uncharacterized LOC105371976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:7577695-7578451 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:7727774-7728973 Neighboring gene NANOG hESC enhancer GRCh37_chr18:7734824-7735325 Neighboring gene uncharacterized LOC124904242 Neighboring gene NANOG hESC enhancer GRCh37_chr18:7957710-7958211 Neighboring gene Sharpr-MPRA regulatory region 1937 Neighboring gene small nucleolar RNA U3 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:8045403-8046602 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:8062594-8063198 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:8066484-8067132 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:8084054-8084920 Neighboring gene NANOG hESC enhancer GRCh37_chr18:8088787-8089335 Neighboring gene uncharacterized LOC107985119 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:8141627-8142826 Neighboring gene Sharpr-MPRA regulatory region 9307 Neighboring gene NANOG hESC enhancer GRCh37_chr18:8187471-8187972 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:8232624-8233446 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:8296475-8297674 Neighboring gene uncharacterized LOC100192426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8367345-8367845 Neighboring gene uncharacterized LOC124904241 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8401222-8401752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8406579-8407223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8422085-8422585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:8423331-8423954 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:8424831-8425474 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:8425475-8426118 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:8438111-8438317 Neighboring gene COP1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 50, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer. Liu P, et al. Cell Death Dis, 2020 Aug 11. PMID 32826853, Free PMC Article
  2. A protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cells. Phillips-Mason PJ, et al. J Cell Biochem, 2014 Sep. PMID 24771611, Free PMC Article
  3. Protein tyrosine phosphatase µ (PTP µ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis. Sun PH, et al. PLoS One, 2012. PMID 23185569, Free PMC Article
  4. Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo. Kaur H, et al. Neuro Oncol, 2012 May. PMID 22505657, Free PMC Article
  5. Diverse injurious stimuli reduce protein tyrosine phosphatase-μ expression and enhance epidermal growth factor receptor signaling in human airway epithelia. Hyun SW, et al. Exp Lung Res, 2011 Aug. PMID 21649524, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A quantitative trait GWAS on lens thickness identifies novel risk loci on PTPRM in the narrow angle individuals susceptible to PACG.
    Title: A quantitative trait GWAS on lens thickness identifies novel risk loci on PTPRM in the narrow angle individuals susceptible to PACG.
  2. Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.
    Title: Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.
  3. PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling.
    Title: PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling.
  4. High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer.
    Title: High expression of PTPRM predicts poor prognosis and promotes tumor growth and lymph node metastasis in cervical cancer.
  5. PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.
    Title: PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.
  6. Results suggest increased post-translational modification of RPTPmu N-glycans by GnT-V attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCgamma-PKC pathways.
    Title: β1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLCγ-PKC pathways.
  7. Study determined that, in addition to the furin-processed form of PTPmicro, a pool of 200 kDa full-length PTPmicro exists at the plasma membrane that is cleaved directly by ADAM to generate a larger shed form of the PTPmicro extracellular segment.
    Title: A protease storm cleaves a cell-cell adhesion molecule in cancer: multiple proteases converge to regulate PTPmu in glioma cells.
  8. Decreased expression of PTPRM in breast cancer is correlated with poor prognosis and inversely correlated with disease-free survival.
    Title: Protein tyrosine phosphatase µ (PTP µ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis.
  9. Loss of PTPmu by proteolysis causes glioblastoma.
    Title: Protein tyrosine phosphatase mu regulates glioblastoma cell growth and survival in vivo.
  10. Results suggest that miR-221 and -222 regulate glioma tumorigenesis at least in part through the control of PTPmu protein expression.
    Title: miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
EBI GWAS Catalog
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC166994

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane receptor protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retina layer formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase mu
Names
protein tyrosine phosphatase mu
protein tyrosine phosphatase, receptor type, mu polypeptide
NP_001098714.1
NP_001365071.1
NP_001365072.1
NP_001365073.1
NP_001365074.1
NP_001365075.1
NP_001365076.1
NP_002836.3
XP_011524010.1
XP_011524014.1
XP_016881383.2
XP_016881384.2
XP_016881385.2
XP_016881386.2
XP_016881387.2
XP_016881388.2
XP_016881389.2
XP_016881390.2
XP_016881391.2
XP_016881392.2
XP_016881393.2
XP_016881398.1
XP_016881399.2
XP_016881400.1
XP_016881401.2
XP_047293670.1
XP_047293671.1
XP_047293672.1
XP_047293673.1
XP_047293674.1
XP_047293675.1
XP_047293676.1
XP_047293677.1
XP_047293678.1
XP_047293679.1
XP_047293680.1
XP_054174899.1
XP_054174900.1
XP_054174901.1
XP_054174902.1
XP_054174903.1
XP_054174904.1
XP_054174905.1
XP_054174906.1
XP_054174907.1
XP_054174908.1
XP_054174909.1
XP_054174910.1
XP_054174911.1
XP_054174912.1
XP_054174913.1
XP_054174914.1
XP_054174915.1
XP_054174916.1
XP_054174917.1
XP_054174918.1
XP_054174919.1
XP_054174920.1
XP_054174921.1
XP_054174922.1
XP_054174923.1
XP_054174924.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105244.2 → NP_001098714.1  receptor-type tyrosine-protein phosphatase mu isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP000897, AP001091, AP001094, AP005118, AP005227, AP005900
    Consensus CDS
    CCDS58613.1
    UniProtKB/TrEMBL
    E7EPS8
    Related
    ENSP00000463325.1, ENST00000580170.6
    Conserved Domains (8) summary
    cd06263
    Location:27 → 182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:912 → 1166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192 → 278
    IG_like; Immunoglobulin like
    cd00047
    Location:939 → 1166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499 → 581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain

  2. NM_001378142.1 → NP_001365071.1  receptor-type tyrosine-protein phosphatase mu isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    UniProtKB/TrEMBL
    B4DGA3
    Conserved Domains (7) summary
    smart00060
    Location:69 → 148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170 → 264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:671 → 943
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:1029 → 1234
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286 → 361
    fn3; Fibronectin type III domain
    pfam00047
    Location:19 → 61
    ig; Immunoglobulin domain
    pfam18861
    Location:443 → 550
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

  3. NM_001378143.1 → NP_001365072.1  receptor-type tyrosine-protein phosphatase mu isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    UniProtKB/TrEMBL
    B4DGA3
    Conserved Domains (7) summary
    smart00060
    Location:69 → 148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170 → 264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:684 → 956
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:1042 → 1247
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286 → 361
    fn3; Fibronectin type III domain
    pfam00047
    Location:19 → 61
    ig; Immunoglobulin domain
    pfam18861
    Location:443 → 550
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

  4. NM_001378144.1 → NP_001365073.1  receptor-type tyrosine-protein phosphatase mu isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    UniProtKB/TrEMBL
    B4DGA3
    Conserved Domains (6) summary
    smart00060
    Location:69 → 148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170 → 264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:696 → 968
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:1054 → 1259
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286 → 361
    fn3; Fibronectin type III domain
    pfam00047
    Location:19 → 61
    ig; Immunoglobulin domain

  5. NM_001378145.1 → NP_001365074.1  receptor-type tyrosine-protein phosphatase mu isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    UniProtKB/TrEMBL
    B4DGA3
    Conserved Domains (5) summary
    smart00060
    Location:170 → 254
    FN3; Fibronectin type 3 domain
    cd14633
    Location:709 → 981
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:1067 → 1272
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286 → 361
    fn3; Fibronectin type III domain
    pfam00047
    Location:19 → 61
    ig; Immunoglobulin domain

  6. NM_001378146.1 → NP_001365075.1  receptor-type tyrosine-protein phosphatase mu isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    UniProtKB/TrEMBL
    B4DGA3
    Conserved Domains (7) summary
    smart00060
    Location:69 → 148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170 → 264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:684 → 973
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:1059 → 1264
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286 → 361
    fn3; Fibronectin type III domain
    pfam00047
    Location:19 → 61
    ig; Immunoglobulin domain
    pfam18861
    Location:443 → 550
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

  7. NM_001378147.1 → NP_001365076.1  receptor-type tyrosine-protein phosphatase mu isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    UniProtKB/TrEMBL
    B4DGA3
    Conserved Domains (6) summary
    smart00060
    Location:69 → 148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170 → 264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:709 → 998
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:1084 → 1289
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286 → 361
    fn3; Fibronectin type III domain
    pfam00047
    Location:19 → 61
    ig; Immunoglobulin domain

  8. NM_002845.4 → NP_002836.3  receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

    See identical proteins and their annotated locations for NP_002836.3

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP000897, AP001091, AP001094, AP005118, AP005227, AP005900
    Consensus CDS
    CCDS11840.1
    UniProtKB/Swiss-Prot
    A7MBN1, D3DUH8, J3QL11, P28827
    UniProtKB/TrEMBL
    E7EPS8
    Related
    ENSP00000331418.8, ENST00000332175.12
    Conserved Domains (8) summary
    cd06263
    Location:27 → 182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:899 → 1153
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192 → 278
    IG_like; Immunoglobulin like
    cd00047
    Location:926 → 1153
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499 → 581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    7567316..8406856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525708.3 → XP_011524010.1  receptor-type tyrosine-protein phosphatase mu isoform X7

    UniProtKB/TrEMBL
    E7EPS8
    Conserved Domains (8) summary
    cd06263
    Location:27 → 182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:937 → 1208
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192 → 278
    IG_like; Immunoglobulin like
    cd00047
    Location:964 → 1208
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499 → 581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain

  2. XM_047437715.1 → XP_047293671.1  receptor-type tyrosine-protein phosphatase mu isoform X15

  3. XM_011525712.3 → XP_011524014.1  receptor-type tyrosine-protein phosphatase mu isoform X12

    UniProtKB/TrEMBL
    E7EPS8
    Conserved Domains (8) summary
    cd06263
    Location:27 → 182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:912 → 1183
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192 → 278
    IG_like; Immunoglobulin like
    cd00047
    Location:939 → 1183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499 → 581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain

  4. XM_047437714.1 → XP_047293670.1  receptor-type tyrosine-protein phosphatase mu isoform X13

  5. XM_047437717.1 → XP_047293673.1  receptor-type tyrosine-protein phosphatase mu isoform X17

  6. XM_047437716.1 → XP_047293672.1  receptor-type tyrosine-protein phosphatase mu isoform X16

  7. XM_047437724.1 → XP_047293680.1  receptor-type tyrosine-protein phosphatase mu isoform X28

  8. XM_017025911.2 → XP_016881400.1  receptor-type tyrosine-protein phosphatase mu isoform X25

    UniProtKB/TrEMBL
    B4E143

  9. XM_047437723.1 → XP_047293679.1  receptor-type tyrosine-protein phosphatase mu isoform X27

  10. XM_017025894.2 → XP_016881383.2  receptor-type tyrosine-protein phosphatase mu isoform X1

  11. XM_017025897.2 → XP_016881386.2  receptor-type tyrosine-protein phosphatase mu isoform X4

  12. XM_017025895.2 → XP_016881384.2  receptor-type tyrosine-protein phosphatase mu isoform X2

  13. XM_017025898.2 → XP_016881387.2  receptor-type tyrosine-protein phosphatase mu isoform X5

  14. XM_017025896.2 → XP_016881385.2  receptor-type tyrosine-protein phosphatase mu isoform X3

  15. XM_017025900.2 → XP_016881389.2  receptor-type tyrosine-protein phosphatase mu isoform X8

  16. XM_017025899.2 → XP_016881388.2  receptor-type tyrosine-protein phosphatase mu isoform X6

  17. XM_017025902.2 → XP_016881391.2  receptor-type tyrosine-protein phosphatase mu isoform X10

  18. XM_017025903.2 → XP_016881392.2  receptor-type tyrosine-protein phosphatase mu isoform X11

  19. XM_017025901.2 → XP_016881390.2  receptor-type tyrosine-protein phosphatase mu isoform X9

  20. XM_017025904.2 → XP_016881393.2  receptor-type tyrosine-protein phosphatase mu isoform X14

    Related
    ENSP00000382927.4, ENST00000400053.8

  21. XM_047437721.1 → XP_047293677.1  receptor-type tyrosine-protein phosphatase mu isoform X22

  22. XM_017025912.2 → XP_016881401.2  receptor-type tyrosine-protein phosphatase mu isoform X26

  23. XM_017025910.2 → XP_016881399.2  receptor-type tyrosine-protein phosphatase mu isoform X23

  24. XM_047437722.1 → XP_047293678.1  receptor-type tyrosine-protein phosphatase mu isoform X24

  25. XM_047437718.1 → XP_047293674.1  receptor-type tyrosine-protein phosphatase mu isoform X18

  26. XM_047437719.1 → XP_047293675.1  receptor-type tyrosine-protein phosphatase mu isoform X19

  27. XM_017025909.2 → XP_016881398.1  receptor-type tyrosine-protein phosphatase mu isoform X21

    UniProtKB/TrEMBL
    B4DGA3

  28. XM_047437720.1 → XP_047293676.1  receptor-type tyrosine-protein phosphatase mu isoform X20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    7730572..8570006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318930.1 → XP_054174905.1  receptor-type tyrosine-protein phosphatase mu isoform X7

  2. XM_054318938.1 → XP_054174913.1  receptor-type tyrosine-protein phosphatase mu isoform X15

  3. XM_054318935.1 → XP_054174910.1  receptor-type tyrosine-protein phosphatase mu isoform X12

  4. XM_054318936.1 → XP_054174911.1  receptor-type tyrosine-protein phosphatase mu isoform X13

  5. XM_054318940.1 → XP_054174915.1  receptor-type tyrosine-protein phosphatase mu isoform X17

  6. XM_054318939.1 → XP_054174914.1  receptor-type tyrosine-protein phosphatase mu isoform X16

  7. XM_054318949.1 → XP_054174924.1  receptor-type tyrosine-protein phosphatase mu isoform X28

  8. XM_054318947.1 → XP_054174922.1  receptor-type tyrosine-protein phosphatase mu isoform X25

  9. XM_054318948.1 → XP_054174923.1  receptor-type tyrosine-protein phosphatase mu isoform X27

  10. XM_054318945.1 → XP_054174920.1  receptor-type tyrosine-protein phosphatase mu isoform X23

  11. XM_054318924.1 → XP_054174899.1  receptor-type tyrosine-protein phosphatase mu isoform X29

  12. XM_054318927.1 → XP_054174902.1  receptor-type tyrosine-protein phosphatase mu isoform X32

  13. XM_054318925.1 → XP_054174900.1  receptor-type tyrosine-protein phosphatase mu isoform X30

  14. XM_054318928.1 → XP_054174903.1  receptor-type tyrosine-protein phosphatase mu isoform X33

  15. XM_054318926.1 → XP_054174901.1  receptor-type tyrosine-protein phosphatase mu isoform X31

  16. XM_054318931.1 → XP_054174906.1  receptor-type tyrosine-protein phosphatase mu isoform X35

  17. XM_054318929.1 → XP_054174904.1  receptor-type tyrosine-protein phosphatase mu isoform X34

  18. XM_054318933.1 → XP_054174908.1  receptor-type tyrosine-protein phosphatase mu isoform X37

  19. XM_054318934.1 → XP_054174909.1  receptor-type tyrosine-protein phosphatase mu isoform X38

  20. XM_054318932.1 → XP_054174907.1  receptor-type tyrosine-protein phosphatase mu isoform X36

  21. XM_054318937.1 → XP_054174912.1  receptor-type tyrosine-protein phosphatase mu isoform X39

  22. XM_054318946.1 → XP_054174921.1  receptor-type tyrosine-protein phosphatase mu isoform X40

  23. XM_054318941.1 → XP_054174916.1  receptor-type tyrosine-protein phosphatase mu isoform X18

  24. XM_054318942.1 → XP_054174917.1  receptor-type tyrosine-protein phosphatase mu isoform X19

  25. XM_054318944.1 → XP_054174919.1  receptor-type tyrosine-protein phosphatase mu isoform X21

  26. XM_054318943.1 → XP_054174918.1  receptor-type tyrosine-protein phosphatase mu isoform X20

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28827.2 GenPept UniProtKB/Swiss-Prot:P28827

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